Biomedical subjects

C L Goodridge

Publications and source records attributed to C L Goodridge.

3 recordsLinked to original sources

PubMed2003

Sampling and characterization of pharmaceutical powders and granular blends.

We use a variety of experimental results to illustrate issues and challenges involved in the sampling and characterization of pharmaceutical mixtures. Accurate and reliable characterization of granular mixtures is hindered by both the complexity of granular systems and the lack of validated and reliable sampling technology and techniques. Both sampling tools and sampling protocols are critically important for accurate characterization. Using cohesive and free-flowing powders and four thief probe designs, we reveal a large potential for extremely misleading results as well as severe disturbance of the granular bed. We also discuss results from several experiments designed to test the validity of various sampling protocols by varying parameters such as sampling location and frequency of sampling. These experiments illustrate the importance of effective sampling procedures to achieve the best and most efficient results.

Powders↗

PubMed2001

Detecting functional relationships between simultaneous time series.

We describe a method to characterize the predictability and functionality between two simultaneously generated time series. This nonlinear method requires minimal assumptions and can be applied to data measured either from coupled systems or from different positions on a spatially extended system. This analysis generates a function statistic, Theta(c(0)), that quantifies the level of predictability between two time series. We illustrate the utility of this procedure by presenting results from a computer simulation and two experimental systems.

Journal Article↗

PubMed2001

Functional dependence and quasiperiodicity in the spatiotemporal dynamics of yttrium iron garnet films.

When thin films of yttrium iron garnet (YIG) are placed in a magnetic field and driven at microwave (rf) frequencies, nonlinear interactions within the material cause the normal microwave spin precession to be modulated at lower frequencies. We measure these lower frequency (kHz) signals at two spatially separated locations on the YIG film and use linear and nonlinear analysis to study the functional dependence of the spin dynamics at one location on the spin dynamics at the other location. We see dynamical states where nonlinear analysis can detect a functional dependence that the linear analysis fails to reveal.

Journal Article↗