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Biomedical subjects

C L Hatch

Publications and source records attributed to C L Hatch.

22 records · Page 2Linked to original sources
PubMed1983

Minor histone 2A variants and ubiquinated forms in the native H2A:H2B dimer.

Histone octamers from calf thymus were separated into (H3:H4)2 tetramers and H2A:H2B dimers by chromatography through Sephadex G100. The tetramers and dimers were analyzed for variants, ubiquitin adducts, and proteolyzed forms. The minor histone variants H2A.X and H2A.Z were found to be associated with histone H2B as H2A.X:H2B and H2A.Z:H2B dimers, respectively. Ubiquitin adducts of the H2A's and H2B were also present in H2A:H2B dimers.

Animals↗
PubMed1976

Fine structure of active ribosomal genes.

The structure of active ribosomal genes in the newt Notophthalmus viridescens has been studied at the higher resolution permitted by negative staining. Spherical particles, 70 A to 100 A in diameter are seen on the non-transcribing "spacer" regions, but were absent from certain regions of the transcribing "matrix". The matrix core often appears thicker than a double strand of DNA. These results are discussed in the light of the recently discovered subunit structure of chromatin, and in relation to the question of the disposition of histones during transcription.

Animals↗