Biomedical subjects

C L Mackenzie

Publications and source records attributed to C L Mackenzie.

4 recordsLinked to original sources

PubMed2001

Worst-case prediction strategy in force programming when visual information is obstructed.

A person's strategy for applying force while lifting an object is dependent upon visual cues. This study investigated the alteration of strategy in force programming when visual information about an object's size was obstructed at the moment of lifting. Seven subjects were instructed to use a precision grip for repeated lifts of a cube-like grip apparatus attached to a box. The grip apparatus was a special device designed to measure grip and load forces. Three different-sized plastic boxes of equal weight were pseudorandomly presented by attaching them beneath the grip apparatus to the subjects in two visual conditions. In the Full-vision condition, subjects could view the box's size prior to lifting. In the Obstructed-vision condition, a screen prevented subjects from seeing the box size prior to lifting. In the Full-vision condition, the grip force and load force used by subjects on the grip apparatus increased with box size. In contrast, the subjects in the Obstructed-vision condition used forces appropriate for the largest box regardless of box size. The present results suggest that absence of size information may cause an alteration of strategy used to determine force output in that subjects may apply a maximum force adequate for the largest box, which could be called a "worst-case" prediction strategy, i.e., when there is doubt, the most secure lift may be selected for all possible cases.

Adult↗

PubMed2000

Maternal thyroid disease: a risk factor for newborn encephalopathy in term infants.

Two previously published studies of term newborn encephalopathy showed that maternal thyroid disease to be a risk factor. From these studies we identified 13 case and three control mothers with thyroid disease and investigated them further. The majority of affected case mothers had idiopathic or autoimmune hypothyroidism. Compared with control mothers, case mothers had fewer thyroid function tests in pregnancy, were more likely to remain on the same dose of medication throughout pregnancy and to have experienced other pregnancy complications. The association between maternal thyroid disease and encephalopathy may be the result of a series of different causal pathways, some of which are suggested by our data.

Brain Diseases↗

PubMed1997

The effects of task constraints on the organization of interception movements.

In the light of the intensity coupling effects reported in the literature, subjects' capacities for independently controlling the absolute velocity of their movement at the point of interception was evaluated by asking them to learn to propel orthogonally approaching balls, varying in their speed of approach, into target boxes placed at various distances from the interception point. As required for successful accomplishment of the task, movement velocity was found to be adapted to the distance to be covered, with the near target giving rise to lower velocities and the far target giving rise to higher velocities even when the conditions were presented in random order. Nevertheless, even though target distance accounted for a substantial proportion of the total variance, a small but significant effect of ball approach speed on movement velocity was found, suggesting that intensity coupling is a persistent but modulable phenomenon in interception tasks.

Adaptation, Physiological↗

PubMed1977

Glucan common to the microcyst walls of cyst-forming bacteria.

Chemical analysis indicated that D-glucose is tha major neutral monosaccharide present in the microcysts of a range of gram-negative bacteria. Varying amounts of other neutral sugars were found. The glucose was mainly present as a glucan that could be extracted from microcysts of representative strains with alkali or mild acid treatment. The glucan could be identified as an alpha-1,3-linked polymer on the basis of (i) periodate resistance of the extracted polymer and the material present in microcysts; (ii) lectin agglutination of the microcysts; (iii) lectin precipitation of the extracted glucans; and (iv) susceptibility of the glucan either in the walls or after extraction to a specific alpha-1,3-glucanase from Aspergillus nidulans, yielding glucose as the sole hydrolysis product. The galactosamine found in microcysts of Myxococcus xanthus by other workers is clearly a component of another polymer, distinct from the glucan. The presence of an alpha 1,3-linked glucan, common to microcyst walls of various bacterial genera, probably contributes to the rigidity of the walls of these forms and, inter alia, to their resistance to ultrasonic treatment. Preliminary experiments indicate that the gulcan is discarded on germination of the microcysts rather than being broken down by specific enzymes.

Agglutination Tests↗