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Biomedical subjects

C L Waltemath

Publications and source records attributed to C L Waltemath.

17 recordsLinked to original sources
PubMed1976

Lidocaine and increased respiratory resistance produced by ultrasonic aerosols.

Respiratory resistance significantly increased from 5.0 to 8.0 cm H2O/1/sec in anesthetized patients who were given ultrasonically nebulized water for 20 minutes via an endotracheal tube. Intravenous administration of lidocaine failed to reverse the provoked increase in resistance. In another group, respiratory resistance significantly increased from 5.8 to 7.5 cm H2O/1/sec in response to nebulized water despite prior and con-current intravenous administration of lidocaine. In a third group, initial respiratory resistance was 5.6 cm H2O/1/sec and did not increase during a 20-minute challenge with intratracheally administrered ultrasonically nebulized 2 per cent lidocaine. In a final group, resistance was increased from 5.0 to 6.9 cm H2O/1/sec with nebulized water. When challenge was continued with nebulized 2 per cent lidocaine, resistance remained elevated for about 10-12 minutes. It then decreased and returned to its initial control value at about 17 minutes, despite continuing lidocaine aerosol administration. Lidocaine, when administered intratracheally as an aerosol, both prevented and reversed provoked increases in respiratory resistance. Intravenously administered lidocaine was ineffective. Intratracheal administration of ultrasonically nebulized lidocaine might be another useful technique for management of bronchoconstriction in anesthetized patients.

Aerosols↗
PubMed1975

The effect of pH and blood gas correction in DPG and plasma potassium content of stored blood.

During storage of CPD preserved blood, red cell DPG decreases and plasma potassium increases, the changes becoming more marked with increasing duration of storage. Correction of the blood gas and pH alterations of stored blood decreases plasma potassium and increases red cell DPG, but they do not return to normal except in blood stored less than seven days. There is a highly significant correlation between increasing red cell DPG and decreasing plasma potassium as the pH and blood gases of stored blood are restored to physiological range.

Acid-Base Equilibrium↗
PubMedDate not supplied

Measurement of closing volume in apneic subjects.

Closing volume measurement was adapted for application in apneic intubated, artifically ventilated subjects. A bolus of nitrogen was used as the marker gas. Inspiration and exhalation at a slow, uniform rate between residual volume and total lung capacity was provided by a 7000-ml syringe. Closing volumes in seven anesthetized subjects were similar to those reported for supine, conscious individuals by previous investigators. This adaptation of closing volume measurement should be useful in studying pulmonary dysfunction during anesthesia and during artificial ventilation of patients in respiratory failure.

Adult↗