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Biomedical subjects

C L d'Auzac

Publications and source records attributed to C L d'Auzac.

4 recordsLinked to original sources

[Quality of life after transplantation].

The fact of having surmounted such a major health problem as failure of a vital organ makes it predictable that subjective indexes of quality of life after transplantation will be as good as or better than those of the general population. Many authors have studied whether this hypothesis is valid. Such study presents many methodological problems: the need to define rehabilitation, to establish an absolute or relative evaluation concerning a previous state or that of the general population, and to take into account residuel constraints as well as failures. Several studies concerning one group, one organ or the means of improving rehabilitation are presented. The composition of a good follow-up team and the aspect of physical activity are stressed. It is suggested that the goal of treatment by transplantation be multidisciplinary action to achieve and maintain the best possible rehabilitation of the patient.

Female↗

[Correction of selenium deficiency in patients with renal failure undergoing hemodialysis].

Plasma selenium levels (p Se) as well as glutathione peroxidase activity in plasma (p GPx) and in erythrocytes (e GPx) were measured in 39 haemodialysis patients. Glutathione peroxidase is a selenium-dependent enzyme which protects cells against oxidation. The mean level values obtained were significantly lower in patients than in controls: p Se: 38 +/- 14 versus 88 +/- 17 micrograms/l; p GPx: 15 +/- 32 versus 334 +/- 41 IU/l; e GPx: 19 +/- 4 versus 26 +/- 4 IU/g Hb. These values were found to correlate significantly with the duration of dialysis and with the type of membrane utilized. The total muscular mass was significantly smaller in patients with the lowest p Se or p GPx values. At echocardiography, septal hypertrophy correlated with both p Se and p GPx. Twenty patients were supplemented with sodium selenite administered orally at the end of each haemodialysis session during 6 months. After this period, muscular mass and septal hypertrophy were decreased and the echocardiographic contractility parameters were improved, albeit not significantly.

Adult↗