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Biomedical subjects

C Lachance

Publications and source records attributed to C Lachance.

27 records · Page 2Linked to original sources

Posttraumatic recovery of traumatized newborns: effects on neuromotor and cognitive development during their first 6 months.

Recovery after perinatal cerebral traumatism was studied in a group of 20 traumatized infants. The effects on the sequence of development during the next 6 months were observed for both motor and cognitive development and were compared with a control group of 20 normal babies. Results showed a significant delay for the abnormal group and a different recovery pattern between these two aspects of development. Motor development reached a normal level at 4 months, whereas cognitive development was still impaired at 6 months. These results were discussed in terms of possibly longer effects of perinatal traumatism on higher cortical functions than on motor functions.

Brain Damage, Chronic↗

Congenital esophagobronchial fistula in the adult.

Communications between the esophagus and the tracheobronchial tree in adults are usually acquired and are generally caused by tumour, trauma or infection. Congenital fistulas persisting to adult life are uncommon. The authors present the case of a 72-year-old woman with a congenital fistula between the esophagus and the posterior segmental bronchus of the lower lobe of the left lung. The relative lack of symptoms in this patient for so many years is a well recognized feature of such fistulas. The fistula and lower lobe of the left lung were excised. Some of the reported cases of congenital esophagobronchial fistulas in adults are reviewed and the clinical, radiologic and histologic features of this entity are described.

Aged↗

Use of biliary drainage in diagnosis of biliary tract disease.

Thirty-five patients with biliary-type symptoms and normal oral cholecystograms were found to have either cholesterol crystals, calcium bilirubinate pigment or leucocytes in gallbladder bile collected through duodenal drainage. All underwent cholecystectomy. The gallbladders all showed histological evidence of chronic cholecystitis and/or cholesterolosis. In addition, four gallbladders contained calculi. Cholecystectomy is recommended as treatment for a selected group of patients with duodenal bile crystals or pigment.

Adolescent↗

Arterial complications of Ehlers-Danlos syndrome.

Two patients considered to be examples of the Type IV or "arterial" variety of the Ehlers-Danlos Syndrome (EDS) are presented. In case 1 there seems to be little doubt about the diagnosis. Case 2, which is currently under treatment also appears to be an example of EDS, Type IV. The multiple arterial aneurysms and the findings on the skin biopsy appear to substantiate the diagnosis. These two cases demonstrate some of the features of the Type IV variety of EDS. In the first case visceral artery aneurysms dominated the clinical picture and in the second case peripheral arterial aneurysms were dominant. In neither case were the classical manifestations of the disorder, skin hyperelasticity and joint hypermobility, prominent.

Adult↗

Clinical and nutritional impacts of removing bisulfite from neonatal parenteral nutrition.

There is a general willingness to eliminate sulfites from the diet because of adverse reactions. Because little is known about the biological effects of these antioxidants in vivo, we compared clinical and nutritional parameters in newborn infants receiving two parenteral amino acid solutions containing either 300 mg/dl or no metabisulfite. The primary objective was to verify whether decreasing the sulfur content of parenteral nutrition would diminish the calciuria of newborn infants. In a crossover design, 18 newborn infants received two regimens differing only in their metabisulfite content. Nitrogen and mineral balances; clinical parameters such as mean heart and respiratory rates, body temperature, and transcutaneous PO2 and PCO2 (n = 7); and energy expenditure were similar in both regimens. Withdrawing bisulfites from the diet did not change calciuria, put an extra burden on the infant's metabolic adaptation, or cause short-term clinical repercussions.

Amino Acids↗