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Biomedical subjects

C Ladefoged

Publications and source records attributed to C Ladefoged.

18 recordsLinked to original sources
PubMed1991

[Prognostic factors in pigmented villonodular synovitis].

By means of the diagnostic register, all of the patients in the County of Funn with the diagnosis pigmented villonodular synovitis (PVS) during the years 1973 to 1987 were localized. Out of 22 patients, 19 were followed-up clinically and radiologically. Fifteen patients had PVS in a knee, 63% were women. The diagnosis was established late. Repeated punctures of the knee with dark aspirate without relevant trauma should raise the suspicion of PVS. The clinical course of the disease could not be related to the radiographic findings or the histology but depended rather on the localization. In some patients, PVS ran a more aggressive course and arthroses were observed electively in patients treated early. The prognosis in cases diagnosed early was not better but, as treatment yielded considerable relief of symptoms, early treatment was considered to be of value. This consists of local resection of the nodular PVS elements and as radical synovectomy as possible in the diffuse cases. Treatment of recurrences should depend on the symptoms and the degree of possible arthrosis. One patient who had had three recurrences received irradiation with good results. Restricted joint mobility after synovectomy is treated effectively with brisement.

Adolescent↗
PubMed1990

Malignant melanoma. Changing trends in factors influencing metastasis-free survival from 1964 to 1982.

Seven hundred fourteen patients with cutaneous melanoma in clinical Stage I treated between 1964 and 1982 were included in this study. In an analysis of metastasis-free survival, thickness of the tumor, ulceration, gender, epithelioid cells as predominant cells in the tumor, and localization of the tumor were found to be independent prognostic factors. In a time trends analysis, the distributions of three of the prognostic factors (thickness of the tumor, ulceration, and inflammatory cell infiltrate) were found to shift during the last decade in the direction of improved prognosis, indicating that tumors are detected earlier than before. The distributions of two other factors (cell type and location of the tumors) shifted in the direction of deteriorated prognosis, suggesting partly that the biologic nature of the disease may have changed and partly that other behavioral factors may have played a role.

Female↗
PubMed1989

[Urine cytology as a supplement to cystoscopy and biopsy in the control of bladder tumors].

Throughout the years several investigations have either recommended or discredited exfoliative urine cytology because of high incidence of false negative or false positive results. Most authors agree that high grade bladder tumors are diagnosed with fairly high certainty (80-87%) by using exfoliative urine cytology whereas the value of urine cytology of low grade bladder tumors is uncertain. This investigation, including 200 patients who came for cystoscopic control of bladder tumors, revealed 87% accordance between cystoscopic biopsy and exfoliative urine cytology of high grade tumors while there were 47% false negative and no false positive of low grade tumors. On this background, it must be concluded that exfoliative urine cytology is an important investigation in diagnosing and controlling patients with bladder tumors, but the method can not always stand alone.

Aged↗
PubMed1989

Synovial haemangiopericytoma of the knee joint.

We report a case of haemangiopericytoma occurring intra-articularly in the synovium of the knee joint. This is a rare tumour which, as far as is known to the authors, has not previously been described in a subsynovial site.

Female↗
PubMed1989

Amyloid deposits in surgically removed articular and periarticular tissue.

In tissue from 13 of 30 patients subjected to meniscectomy, amyloid degeneration was found to varying extent along the surface of the meniscus. Tissue from 30 synovectomies, 30 bursectomies and 30 ganglia showed amyloid deposits in four, six and eight cases, respectively. Amyloid was found significantly more frequently in older patients, but there was no sex difference and no relation to duration of the symptoms or to other histological changes in the tissue. Micro-deposits of amyloid in joint tissue and tissue neighbouring joints are a frequent finding, especially in elderly persons, but the clinical significance of this finding is not clear.

Adolescent↗
PubMed1989

The influence of resection margin on prognosis in clinical stage I malignant melanoma of the lower leg.

The incidence of local recurrence and cumulative survival rate were compared for two groups of patients with stage I malignant melanoma of the lower leg. Group 1 included 119 patients treated from 1964 to 1978 with a wide local excision extending to the ankle. Group 2 included 58 patients treated from 1978 to 1981 with a 5 cm incision margin in all directions. Lesions within both groups were comparable based on measurements of tumor thickness. However, level of invasion indicated significantly more advanced lesions in the first group. Risk of local recurrence was related to thickness and ulceration. There were no statistically significant differences in frequency of local recurrences or cumulative survival rates between the two groups.

Adolescent↗
PubMed1988

Xanthogranulomatous inflammation of the female genital tract.

We describe three cases of xanthogranulomatous inflammation in the female genital tract--one affecting endometrium, tube and ovary, one affecting tube, ovary and parametrium and one confined to the endometrium. To date, xanthogranulomatous inflammation in the female genital tract has been reported in a total of 19 cases including the present three. The inflammation most often affects the endometrium but involvement of the vagina, cervix, fallopian tube and ovary may also occur.

Aged↗
PubMed1987

Hepatocellular calcification.

Autopsy of a twenty year old girl dying from complications of renal and cardiac failure demonstrated severe hepatocellular calcification, a rare finding. The pathogenesis is thought to be a combination of dystrophic calcification caused by severe centrilobular necrosis and metastatic calcification due to secondary hyperparathyroidism.

Adult↗
PubMed1986

Crushed cartilage in nasal reconstruction.

Experience when using crushed cartilage for restoration of the dorsal nasal contour is presented. The septal cartilage is used as fresh autogenous grafts and as preserved septal cartilage. Implantation of autogenous grafts is preferable. Bank cartilage, however, has the advantage of being easily available and of causing very little reaction in the host organism. Normally, it is absorbed very slowly and replaced by connective tissue, which retains most of the bulk and shape of the implant. The crushed material is pushed in over the undermined nasal dorsum by means of a syringe connected to a plastic tube. When the piston of the loaded syringe is depressed, the cartilage is injected and the crushed cartilage can be moulded under the skin and the shape maintained by a tight dressing. The cartilage serves as a padding, which covers bony defects, smooths out the irregularities of the bone and avoids the open roof syndrome as well as retracted scar formation between skin and bone.

Absorption↗
PubMed1986

Amyloid in intervertebral discs: a histopathological investigation of surgical material from 100 consecutive operations on herniated discs.

Material from 100 consecutive operations on herniated discs has been investigated for amyloid. Various degrees of amyloid degeneration were found in disc tissue from 41 patients. Material from patients over 50 years old showed significantly more amyloid than that from younger patients; there was no sex difference. Eighteen patients had previously been operated on for herniated discs; seven of these (39%) had pyrophosphate deposits in their disc tissue, often in close topographical relation to amyloid. 26% of the patients had calcium phosphate deposits and 29% had slight inflammation--both without relation to amyloid. No pathogenetic correlation between amyloid degeneration and herniation of intervertebral disc tissue could be shown.

Adult↗
PubMed1986

Amyloid deposits in the knee joint at autopsy.

Joint capsule, meniscus, and cartilage from the patella and medial femoral condyle from 30 non-selected autopsies have been investigated for amyloid deposits with light and electron microscopy. Both right and left knee joints from 28 of the 30 autopsy specimens contained amyloid deposits (93%). The amyloid characteristically showed green dichroism in polarised light after staining with alkaline Congo red. The ultrastructural features were also characteristic of amyloid. Amyloid in capsule tissue was found in a subsynovial location, as well as deeper in the capsule tissue, while in the cartilage amyloid was localised along the surface. The meniscus tissue, in particular, contained heavy deposits of amyloid--mainly along the inner margin. Osteoarthritic changes, with fibrillation of the cartilage, were significantly related to amyloid deposition. No pathogenetic correlation between the osteoarthritic changes and amyloid deposition could be shown in the present investigation.

Age Factors↗
PubMed1985

Cranial fasciitis of childhood.

A case of the new entity cranial fasciitis of childhood is reported. It should be regarded as a special type of nodular (pseudosarcomatous) fasciitis. It is characterized by its localization to the cranial bone of young children. Knowledge of this apparently malignant, but actually completely benign lesion is equally important to both neurosurgeons and neuropathologists.

Bone Cysts↗
PubMed1985

Fibroadenoma of the female breast with multinucleated giant cells.

A fibroadenoma in the female breast is described, which contained multiple multinucleated giant cells within the stroma. The investigation indicated the giant cells to be of epithelial nature, caused by epithelial degeneration secondary to myoepithelial swelling of unknown cause. Their presence and morphology could cause anxiety about malignancy, but this was found groundless.

Adenofibroma↗
PubMed1985

Amyloid in intervertebral discs. A histopathological investigation of intervertebral discs from 30 randomly selected autopsies.

Material from intervertebral discs obtained from 30 randomly selected autopsies was examined histologically for amyloid deposits. Various degrees of amyloid degeneration were found in the disc tissue from 28 of the autopsies. In the annulus fibrosus, the amyloid was lying between the thick bundles of collagen fibers, compared to a more diffuse nodular distribution in the nucleus pulposus, frequently in close relation to chondrocytes. With regard to the lumbar discs, a significant correlation was found between the occurrence of islands of chondroid tissue in the annulus fibrosus and amyloid degeneration. Significantly more amyloid was observed in disc tissue in older age groups, while the amount of amyloid was similar in discs from men and women. Calcium-pyrophosphate-dihydrate (pyrophosphate) was found in the tissue of 6 of the 7 women over the age of 70. Calcium phosphate was seen in 22 of the autopsies--more frequently in the annulus fibrosus than in the nucleus pulposus. There was no topographical relationship between calcium phosphate and amyloid.

Adult↗
PubMed1984

Solitary renal metastasis 23 years after extirpation of a bronchial adenoid cystic carcinoma.

In a 47-year-old man left nephrectomy was performed in 1982 because of a solitary metastasis arising from a bronchial adenoid cystic carcinoma which had been extirpated 23 years previously, in 1959. Whole-body CT scanning one year after nephrectomy disclosed no local recurrence or further metastasis. The importance of long follow-up after surgery for adenoid cystic carcinoma is emphasized.

Bronchial Neoplasms↗
PubMed1979

Local articular amyloid deposition in pyrophosphate arthritis. Histological aspects.

A material of 15 cases of histologically examined pyrophosphate arthritis (hip-joint: 7 cases, knee joint: 8 cases) is presented. Amyloid deposits were found in 14 cases and chondromatosis in the subsynovial connective tissue of all the cases. The significance of this high, not previously reported, coincidence is discussed, together with various pathogenetic possibilities, as related to the theories of the genesis of amyloid substance.

Aged↗