Biomedical subjects

C Lampert

Publications and source records attributed to C Lampert.

26 records · Page 2Linked to original sources

PubMed1993

The course of major depressive disorder in adolescents: I. Recovery and risk of manic switching in a follow-up of psychotic and nonpsychotic subtypes.

Fifty-eight adolescents meeting Research Diagnostic Criteria (RDC) for major depressive disorder were observed for 24-months after inpatient admission in a prospective, naturalistic design study to assess time to recovery, risk of manic switching, and level and persistence of psychosocial impairment. Subjects were further categorized as psychotic or nonpsychotic by RDC. The cumulative probability of recovery by 24 months was high (90%); however, the episode was protracted with only 6.9% recovering within 12 weeks and only 29.3% recovering by week 20. Time to recovery did not vary by RDC subtype, but manic switching was observed only among psychotics, at a rate of 28%. Psychotics were more likely than were nonpsychotics to exhibit psychosocial impairment through 6 months of follow-up, but this difference narrows by 24 months. Implications of these findings for understanding developmental effects on the course and treatment of depression in adolescents are discussed.

Adolescent↗

PubMed1991

[Malunited supracondylar and condylar humeral fractures].

We present three important types of posttraumatic deformity of the distal humerus: varus deformity, valgus deformity and complex deformity. Their primary causes are discussed. Slight varus deformities are the result of purely lateral slip of supracondylar fractures or radial overgrowth after a lateral condylar fracture. Severe varus deformities occur after ulnar slip of the distal fragment following supracondylar fracture caused by a rotational deformity. The results after correlation of varus deformities with a rotational deformity are poor. The only way of obviating this problem is to recognize a rotational deformity as soon as possible before adaptation of the elbow occurs, and also to correct it early, if necessary. Valgus deformities occur mostly after radial malunion. Depending on the size of the fragment and the disability of the patient, the fragment should be stabilized-but the potential involvement of the malunion in the elbow function must be borne in mind. Complex deformities and their unknown origins are also discussed. The correction of such deformities depends exclusively on the elbow function. More aggressive primary regimens are urgently needed to prevent the necessity for such secondary corrections, which are very demanding and, depending on the type, have a high failure rate.

Adolescent↗

PubMed1990

Relapse following discontinuation of lithium maintenance therapy in adolescents with bipolar I illness: a naturalistic study.

The authors conducted an 18-month naturalistic prospective follow-up study of 37 adolescents whose bipolar I illness had been stabilized with lithium carbonate during inpatient hospitalization. Thirteen of the patients discontinued prophylactic lithium therapy shortly after discharge. The relapse rate of bipolar illness in these 13 patients was nearly three times higher than the rate in patients who continued lithium prophylaxis without interruption. Early relapse among lithium-treated patients was associated with a greater risk of relapsing again. The authors discuss the theoretical and clinical implications of these findings.

Adolescent↗

PubMed1990

[Extension or osteosynthesis of juvenile femoral shaft fractures--experiences with the external fixator].

Since 1988 14 femoral shaft fractures were primarily treated in children using the AO-external fixation technique. In contrast to the patients treated by extension only, early mobilisation and out-patient management of these patients became possible. However the time of consolidation was prolonged, probably due to the rigidity of the unilateral double tube AO-external fixator and consequently the insufficient dynamisation of the fracture. Despite of technical complications having occurred in two patients we will continue to apply this method of treatment for femoral shaft fractures. This because the above-mentioned fundamental advantages of this osteosynthesis. For future use a new system with improved means of dynamisation is in evaluation.

Adolescent↗

PubMed1989

Cementless press-fit cup. Principles, experimental data, and three-year follow-up study.

The concept of the press-fit cup includes an operative defect as small as possible, achievement of intrinsic stability by press-fit, and surface coating by an orderly, oriented wire mesh coating. The design is a modified hemisphere with flattening in the pole area and oversized cup diameter. A first series of press-fit cups were fitted with titanium nitride-coated stainless steel mesh. The manufacturing of such chemically pure titanium has only recently become feasible. Animal experiments using mountain sheep have shown an increase in the stability of the press-fit cup within the acetabulum with time and progressive bony ingrowth; this was verified in cups retrieved at autopsy. Three hundred eighty-seven first-generation titanium nitride-coated stainless steel mesh implants have been reviewed with a follow-up time of 12 to 39 months (average, 16.6 months). There were no intraoperative complications related to the cup. The roentgenographic follow-up study of 330 (85.1%) hips showed only a single case with a radiolucent line in all zones (1-3) as a roentgenographic sign of loosening, i.e., fibrous ingrowth. Two cups had to be revised due to insufficient primary stability and tilting.

Acetabulum↗

PubMedDate not supplied

A family study of bipolar I disorder in adolescence. Early onset of symptoms linked to increased familial loading and lithium resistance.

Lifetime rates of psychiatric illness were compared in relatives of adolescent probands with bipolar I disorder and in relatives of age-matched schizophrenic controls. Familial aggregation of major affective disorders was observed in bipolar probands, the rate of bipolar I disorder greatly exceeding that reported in relatives of adult bipolar probands. Adolescent probands with childhood onset of psychiatric disturbance were distinguished from probands who had no premorbid childhood psychiatric abnormality in two ways: (1) significantly increased aggregation of bipolar I disorder in first-degree relatives; and (2) poorer antimanic response to lithium carbonate. These data underscore important heterogeneity in adolescent-onset bipolar disorder.

Adolescent↗

PubMedDate not supplied

Cardiac sarcoidosis masquerading as a metastatic tumor: the role of transthoracic and transesophageal echocardiography.

We present an unusual case of biopsy-proven myocardial sarcoidosis in which the transthoracic and transesophageal echocardiographic findings suggested metastatic tumor involvement of the myocardium and pericardium. The pathologic, clinical, and echocardiographic features of cardiac sarcoidosis are reviewed, with emphasis on the role of echocardiography.

Adult↗

PubMedDate not supplied

[Comparative periprosthetic bone density measurements of the proximal femur shaft using dual energy x-ray absorptiometry (DEXA) with experimental "Press Fit-gliding Stem Prosthesis"].

PROBLEM: Periprosthetic bone atrophy caused by stress shielding is one of the problems of non-cemented femoral stems of hip arthroplasty. Stress shielding and thus the loss of bone mass and their dissemination in the proximal part of the femur of conventional non-cemented femoral stems depends on stiffness (E-modules of the material and the geometry) of the implant and on the bonding between implant and bone. All currently implanted non-cemented femoral stems lead to proximal bone loss which goes up to 40-50% of the original bone mineral content. The senior author (E. M.) developed a femoral stem (Press Fit-Gliding Stem PFGS) which shifts relative movements of force-transmission from the bone-implant interface into the interior of the prosthetic system (Inner Bearing-System) and which only transfers forces proximal into the femur. METHOD: The examinations were made in 21 patients between 1 and 6 years after implantation of a Press Fit-Gliding Stem compared with a normal contralateral femur (12), with bilateral PFGS (3) and other bilateral arthroplasty (6). RESULTS: In all 21 patients supplied with a PFGS an increase of bone mineral content (BMC) and bone mineral density (BMC) in zone 7 as well as a marked smaller deviation around the mean value in all zones respectively could be noticed. CONCLUSIONS: With the Dual Energy X-ray Absorptiometry (DEXA)-measurement of bone mineral content (BMC) and bone mineral density (BMD) in all zones according to Gruen could be shown that it is not only possible with regard to a favorable force transmission to avoid the inevitable bone atrophy but on the contrary to induce an increase of bone at the point of local force transmission that is in the region of the calcar femorale (zone 7). CLINICAL RELEVANCE: The Press Fit-Gliding Stem is still in the clinical test-program.

Absorptiometry, Photon↗