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Biomedical subjects

C Lapras

Publications and source records attributed to C Lapras.

At least 55 records · Page 3Linked to original sources
PubMed1989

[Percutaneous injection of methyl-metacrylate in osteoporosis and severe vertebral osteolysis (Galibert's technic)].

The authors present their preliminary experiences using methyl-metacrylate by percutaneous injection for the treatment of osteoporosis and osteolysis of the vertebral body and for vertebral angiomas. The injection of cement strengthens the vertebral body and prevents its collapse. The mixture used consist of 4.80 g of powder with 5 cm3 of monomer liquid. The technique is performed with radiological control under neuroleptanalgesia and a local anesthesia before insertion of the needle. This technique gives good results for the treatment of vertebral pain caused by osteoporosis or osteolysis.

Adult↗
PubMed1989

[Tumors of the pineal region: MRI aspects. Apropos of 20 cases].

MR imaging (0,5 T) was performed in twenty patients with a tumor of the pineal region (17 pathological correlations). To establish the place of this technique, MR imaging data are studied. There is a great variety of tumor types, but the signal of the tumor is usually non specific. The main indication of MR imaging appears to be the evaluation of the extension of the tumor before surgery.

Adolescent↗
PubMed1988

Choroid plexectomy for the treatment of chronic infected hydrocephalus.

Choroid plexectomy was performed for chronic infected hydrocephalus in 17 children via a direct open approach. In 16 cases, the CSF was sterilized soon after the plexectomy. In 37% of cases, the hydrocephalus was arrested without a shunt. The incidence of seizures did not increase after plexectomy. Removal of the choroid plexus was controlled by scintigraphy. Neuropsychological results were not encouraging, probably related to the long history of chronic ventricular infection. Surgical mortality was 6%. Choroid plexectomy should be considered as a possible treatment of chronic infected hydrocephalus in children.

Anti-Bacterial Agents↗
PubMed1988

Brain tumors in infants: a study of 76 patients operated upon.

Seventy-six children were studied who had been operated on for intracranial tumors; they ranged in age from 0 to 2 years. Twenty-nine cases were under 1 year and 47 between 1 and 2 years of age. The outlook was relatively poor regarding the highly malignant tumors, but surprisingly encouraging in benign and low-grade malignant neoplasms. The undesirable effects of complementary oncological treatment in this age category are stressed. On the other hand the importance of radical surgery is emphasized as the best treatment for these lesions.

Antineoplastic Agents↗
PubMed1988

[Intracranial arterial aneurysm in children. A cooperative study. Apropos of 43 cases].

This joint study describes 43 cases of intracranial arterial aneurysms in children diagnosed on the basis of clinical symptoms. In the pediatric age group, this malformation is notable because of the marked sex predilection in males (70%) and an unequal topographic incidence in the circle of Willis, where carotid artery (39.3%) and anterior communicating artery lesions (30%) predominate. The most frequent clinical sign was subarachnoid hemorrhage (81%), although symptoms caused by compression revealed the abnormality in 2.3% of patients. In this series, 11% of the patients suffered a head injury at the time of the hemorrhagic accident; this finding has been reported previously in the literature. Today, treatment is always surgical, consisting in removal of the aneurysmal sac. Surgical results are encouraging; all grade lesions considered together, 63.4% of the children were cured without any sequelae, 19.5% lost one school year but were able to lead a normal life, and 4.8% remained severely handicapped; overall postoperative mortality was 12.3%. Cerebral plasticity and tolerance of spasm in children are fundamental features of this aneurysmal pathology which partially explain the favorable results obtained with surgery.

Adolescent↗
PubMed1988

[Tuberous sclerosis and trigonoseptal tumors].

A series of 9 patients having a tuberous sclerosis associated to a midline ventricular tumour is reported. Microscopically, the presence of giant cells within the lesion is a major characteristic of the disease. The origin of these subependymal giant cells tumours is questionable since astrocytic, neuronal and ependymal features have been noted by several authors providing various denominations. In the literature and in our series as well, the intra-ventricular tumour presented as the initial manifestation of the disease in most of cases, usually with increased intra-cranial pressure symptoms. On CT, the tumour arises in the area of the foramen of Monro and enhances after contrast injection while the other intracranial anomalies of the disease do not enhance. In 8 patients, a direct transcortical transventricular approach was used. 1 patient was treated by shunt only. The results were evaluated according to the degree of the preoperative neuropsychological impairement: there were 3 deaths, 3 "excellent", 2 "fair" and 1 "poor" results. The problem of the surgical indication raises mainly in patients in whom the diagnosis of the tuberous sclerosis is ascertained prior to the diagnosis of the tumour. Since acute C.S.F. blockage or intra-ventricular bleeding may occur during "conservative" treatment, direct approach seems preferable.

Adolescent↗
PubMed1988

'Slit-ventricle syndrome': etiology and treatment.

Between 1970 and 1986, 20 patients were treated for the 'Slit-ventricle syndrome'. Six patients had intermittent proximal shunt malfunction and 14 children had increased intracranial pressure with normal shunt function. All of the children in the second group had a relatively small calvarium. Treatment consisted of proximal shunt revision in the first group and a calvarial expansion procedure in the second. The authors discuss the differential diagnosis of the slit-ventricle syndrome and offer guidelines to appropriate treatment.

Cerebral Ventricles↗
PubMed1988

[Long-term results of the treatment of ruptured intracranial aneurysms. Study of a series of 328 patients hospitalized from 1972 to 1984].

Between 1972 to 1984, 328 patients were admitted in the department of neurosurgery, for the treatment of a ruptured intracranial aneurysm, and being clinically in grades I to IV. These patients were submitted to a deferred surgery protocol. 5.5% of the patients died before surgery, and 94.5% were actually operated on. The follow-up was at least over one year, and up to 14 years (mean 3 years and 8 months). The long term result was appreciated according to the physical status of the patients and the activity resumption (professional, familial and social as well). This long term result was compared to the immediate results, which had been appreciated either at the time of discharge or a few months later. 25.9% of the 328 patients were lost of view, and 74.1% were followed (including pre-operative and operative death). The immediate results were: death 17.7%, poor 7.3%, fair 9.1%, good 66.2%. The long term results were appreciated as follows: Poor 7.3%, Fair (independent but with emotional or psychological difficulties), 14.8%, Good (fully independent) 55.1%. The long term activity resumption (ability to work) was: normal 46.5%, lesser level of work 7.8%, unable to work 20.5%. Out of the patients with a good and fair immediate result, only 66.5% have resumed their previous occupation. 21.2% of these patients did not resume their previous occupation due to psycho.

Activities of Daily Living↗
PubMed1988

[Efficacy of the "8 drugs in a day" protocol in brain tumors in children].

In the present study, the "8 drugs in 1 day" regimen was tested in 54 children: 27 relapses (brain and/or spinal and/or meningeal sites), 10 refractory progressive diseases, 13 macroscopic residual tumors after partial excision and/or radiotherapy; in 4 cases, this regimen was prescribed as first line treatment. The response rate (complete and partial remission) was 46%. Results were very encouraging in medalloblastomas with a response rate of 76.5% whereas in brain stem gliomas it was only 23% and 33% in other astrocytomas. Immediate toxicity, mainly hematological, was very moderate. These results justify to propose this regimen as adjuvant chemotherapy, mostly in medulloblastomas and to plan other similar trials, using the most active drugs which seem presently to be alkylating and platinum-derived agents.

Adolescent↗