Biomedical subjects
Publications and source records attributed to C Laurens.
The appearance of ocular pathological outcomes following an hepatitis B vaccination is uncommon. Among them, acute multiple posterior placoid pigment epitheliopathy has been noticed after injections of Engerix B recombinant vaccine. We describe the case of an 11-year-old child who presented this affection following a Genhevac B recombinant vaccine injection.
Previous studies have shown that serine protease inhibitors promote neurite outgrowth from neuroblastoma cells, sympathetic neurons and sensory ganglia in culture. In the present study, a neurite promoting activity of thrombin inhibitors such as hirudin, D-Phe,Pro,Arg-CH2Cl, and paraamidinophenylalanine derivatives, was found in rat embryo (E17) septal neurons in primary culture. In contrast, no effect was shown on choline acetyltransferase activity of septal fragments in culture. These results suggest that thrombin inhibitors might interact with a thrombin-like protease involved in the control of neurite outgrowth.
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