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Biomedical subjects

C Lazzari

Publications and source records attributed to C Lazzari.

11 recordsLinked to original sources
PubMed1995

Mortality among drug users in the AIDS era.

BACKGROUND: Infection with human immunodeficiency virus type 1 (HIV-1) causes progressive immune deficiency, the acquired immunodeficiency syndrome (AIDS), and death. Mortality, however, particularly with causes other than AIDS, deserves further study. A retrospective cohort study among drug users in Italy was performed to estimated absolute and proportional mortality rates due to AIDS and other causes, with or without HIV-1 infection. METHODS: All subjects who enrolled between January 1980 and July 1990 in the drug treatment programme in the Province of Bologna, Italy, were included in the cohort. Each subject was categorized for HIV-1 antibody status (positive, negative, untested), vital status (in 1990 by national surveillance), and causes of death (by death certificate). Data were analysed with actuarial and time-dependent covariate methods. RESULTS: There were 332 deaths among 4962 drug users who were followed for 21,130 person-years. This mortality rate (1.57 per 100 person-years) was increased 18-fold compared to the general population. Actuarial 10-year mortality estimates were 28.2% for the 2040 HIV-1 positive subjects, 12.1% for the 1859 HIV-1 untested subjects, and 2.5% for the 1063 HIV-1 negative subjects. AIDS contributed to 150 deaths, followed by drug overdose (64 deaths) and trauma (39 deaths). Compared to others in the cohort, mortality with AIDS and non-AIDS causes was reduced for HIV-1 negative subjects. In contrast, mortality for HIV-1 positive subjects was increased with AIDS, trauma, overdose, various bacterial infections, hepatitis, and cirrhosis. CONCLUSIONS: Mortality with HIV-1 infection was associated not only with opportunistic infections and malignancies but also with competing causes of death, particularly hepatic disease. Further investigation is needed to clarify whether alcohol, analgesics, hepatitis viruses, or other agents have enhanced hepatotoxicity for HIV-1 infected patients.

Acquired Immunodeficiency Syndrome↗
PubMed1990

[The basic ideas about the use of the Swan-Ganz catheter].

The haemodinamic monitorization through the Swan-Ganz catheter is a valuable source in the assistance of the critically ill patient. This work is a review on the importance, indication, skills and nursing care in order to use this source.

Catheterization, Swan-Ganz↗
PubMed1986

[Comparative study between cerebral seizure and the climatic trend in the province of Brescia].

This study seeks to identify which of the various climatic parameters is the most significant causative factor for the onset of cerebral ictus or TIA in subjects clinically "at risk". The research was conducted in the province of Brescia, where it was discovered that the most stressful climatic factor was a warm, dry south-westerly wind (SW). It was postulated that such climatic conditions may favour platelet aggregation by means of an increase in the charge of positive ions in the air.

Cerebrovascular Disorders↗
PubMed1986

Singular perturbation theory for open enzyme reaction networks.

The main goal of this paper is to present some results of singular perturbation theory on infinite time intervals justifying the application of the well-known pseudo-steady-state hypothesis for general open enzyme reaction networks. A condition on the input/output function, which allows us to write a suitable reduced system associated with the original complete system, is discussed. The type of convergence between the solutions of the two systems, out of the initial boundary layer, is studied, in relation to the asymptotic behaviour of the degenerate system. We will consider mainly the common cases where the degenerate system has: either (1) an asymptotically (Lyapunov) stable fixed point or (2) an asymptotically orbitally stable periodic solution. Owing to the generality of the results, they can also be applied to several other problems.

Enzymes↗
PubMed1983

[Changes in the activity of plasma beta-endorphin-like-immunoreactivity induced by transcutaneous stimulation of the brain].

A newly devised technique of electrical transcutaneous brain stimulation has been applied to a population of cephalalgic patients in order to assess its proficiency in pain relieving and in increasing the concentration of serum endorphins. A significant pain relief associated with an increase in serum endorphins has been obtained only in those patients in which clinical and instrumental evaluations had identified the headache as one of "organic" origin. By contrast both in "non organic" and in control subjects the technique has proved to be effectiveless. Our results suggest that transcutaneous electrical brain stimulation can affect the release of endogenous opioids relieving pain at least in selected patients.

Adolescent↗