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Biomedical subjects

C Legg

Publications and source records attributed to C Legg.

8 recordsLinked to original sources
PubMed1992

The organisation of fibres within the rat basis pedunculi.

The organisation of corticofugal fibres within the basis pedunculi of rats was studied using wheat germ agglutinin-horseradish peroxidase as an orthograde tracer. Following cortical injections, labelled fibres were distributed within the cerebral peduncle in an orderly way. Fibres which originate from cells in the frontal cortex maintain a position in the ventromedial part of the basis pedunculi. Fibres from the occipital and temporal cortex travel in the most dorsolateral part. Somatosensory fibres travel between these two. The extent of labelled fibres within the peduncles is correlated with the relative density of corticopontine cells arising from different areas of the cerebral cortex.

Animals↗
PubMed1990

Cognitive responses and the control of post-operative pain.

This paper examines the relationship between spontaneous cognitive responses and reported pain experience in an acute pain population. Fifty-two patients, admitted for planned major surgery, had their pain intensity, distress and coping responses assessed 48 hours post-operatively. Significant correlations were obtained between negative responses and ratings of pain intensity and distress. No significant correlation was obtained between the analgesic dose and any other variable. The implications of the findings for the management of post-operative pain are discussed.

Abdomen↗
PubMed1984

A study of the relationship between circulating beta-endorphin-like immunoreactivity and post partum 'blues'.

Plasma beta-endorphin-like immunoreactivity was studied in 43 pregnant women at 36 weeks gestation and in 23 of these at delivery and 24 h post-partum; an attempt made to correlate changes with various social, psychological and obstetric factors, including the 'post-natal blues'. Beta-endorphin levels were elevated at 36 weeks gestation and term, increased to very high levels during labour and fell rapidly within 1 h of delivery. A negative correlation was observed between the woman's estimate of her pain in labour and the beta-endorphin levels post-partum, suggesting an analgesic role for beta-endorphin in labour. A positive correlation was also observed between the levels of beta-endorphin at delivery and the woman's attitude to her pregnancy at 36 weeks and a negative correlation between the 'post-natal blues score' and the beta-endorphin level at 36 weeks. However, the 'blues' did not correlate either with the beta-endorphin level at delivery or 24 h post-partum nor with its rate of fall in the first 24 h. Our general finding that there was no consistent social, psychological or obstetric factor which predisposes women to develop 'post-natal blues' still supports the hypothesis that humoral factors, of which beta-endorphin may be one, rather than psychological factors are important in the genesis of this syndrome.

Endorphins↗
PubMed1978

The role of infant observation in child psychiatry training.

The authors discuss the role of infant observation in the training of child psychiatrists, emphasizing the overriding importance of the subtle but crucial interactions in the mother-infant relationship. Infant observation is valuable in preparing the student as an observer of behavior, and developmental concepts are taught and learned more easily in programs that provide opportunities for observing normal infants. The infant study program in the Department of Psychiatry of the University of Michigan Medical Center is presented as a model.

Child↗
PubMed1976

Some comments on the significance and development of midline behavior during infancy.

With the waning of the tonic neck reflex beginning with the 8th to 12th week, and disappearing, in most instances, by the 16th week, the infant begins to become bilateral and makes symmetrical movements and engages his hands in the midline usually over the chest while in a supine position. The developmental significance of such behavior is considered--for example, its participation in the emerging sense of self and its role in the consolidation of emerging ego skills. Consideration is given to the possible implications of faulty midline behavior for development, and to whether failure to engage in an optimal amount of midline behavior, in interaction with other factors, can be used to alert observers to possible future developmental disturbances.

Autistic Disorder↗
PubMed1976

The replacement child--a developmental tragedy: some preliminary comments.

Some of the clinical and theoretical issues thought to be involved in the psychology of "replacement children" are discussed. A developmental framework is proposed within which to view such children. The replacement child is becoming an identifiable clinical syndrome, and a developmental framework is sorely needed to encourage more systematic research. A replacement child perceives his status differently on both a cognitive and emotional level within the context of each developmental phase, and the affective and associative links need to be reworked each time. We view the status of being a replacement child as a developmental interference insofar as demands are placed on the child's immature ego which he might not yet be equipped to cope with.

Child↗