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Biomedical subjects

C Lehmenkühler

Publications and source records attributed to C Lehmenkühler.

2 recordsLinked to original sources
PubMed1992

[Cortical dysplasia as an epileptogenic focus: reduced binding of 123I-iomezanil with barely perceptible 99mTc-HMPAO SPECT].

In cortical areas associated with an epileptic focus, there is, in the majority of cases, a correlation between decreased benzodiazepine (Bz) receptor binding, detectable with 123I-Iomazenil, and decreased blood flow. A patient with focal epilepsy due to a localized abnormality in cortical differentiation is presented who showed a marked focal decrease in Bz receptor binding and a normal 99mTc-HMPAO SPECT. Based on this case the relation between blood flow and Bz receptor binding in epileptic foci is discussed.

Cerebral Cortex↗
PubMed1991

Decrease of N-methyl-D-aspartate responses by noradrenaline in the rat motorcortex in vivo.

The influence of noradrenaline (NA) on cortical field potential changes (CFPs) induced by the glutamate subreceptor agonist N-methyl-D-aspartate (NMDA) was tested in the motorcortex of anesthetized and artificially ventilated rats. Substances were applied through a 3-barrelled micropipette by pressure ejection in different motorcortical laminae. NMDA elicited negative and NA no or small positive CFPs. Applications of NA before (up to 60 s) or overlapping the ejection of NMDA decreased the amplitude of the negative CFP induced by the excitatory amino acid. The alpha 1-adrenoceptoragonist phenylephrine mimicked the NA effect, whereas the alpha 2-adrenoceptoragonist clonidine had differential actions with decreasing and increasing NMDA elicited CFP. The beta-agonist isoproterenol was without effect. It is suggested that the diminution of NMDA effects by NA may be mediated by an intracellular pathway mechanism.

Animals↗