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Biomedical subjects

C Lekkas

Publications and source records attributed to C Lekkas.

16 recordsLinked to original sources

Experimental degenerative temporomandibular joint disease.

As a possible cause of osteoarthrotic changes of the temporomandibular joint (TMJ), trauma has often been suggested in the literature. Very few authors have tried to test the reliability of this theory by animal experiments. Sixty Wistar albino rats, divided into two main groups, were used in this investigation. In the first group of 10 rats, a trauma of the articular cartilage was inflicted. In the second group, small defects were made on different segments of the articular disk only, avoiding damage to the remaining components of the TMJ. The traumas of the articular cartilage almost completely healed within the experimental period. When the disk was damaged, besides degeneration of the disk itself, changes of the condylar head, similar to changes observed in arthrotic human material, were found.

Animals

Residual cementoblastoma of the mandible.

An unusual case of a residual cementoblastoma in a 24-yr-old man is described. The final diagnosis has been based on the history and the clinical, radiographic and histologic features. The lesion has been removed in toto. During the ten-year follow-up no signs of recurrence have been noticed.

Adult

The anatomical effects of surgically repositioning the disc in the temporomandibular joint of rats. An experimental study.

A sample of 16 rats was used as experimental material to evaluate the effect of surgical repositioning of the disc of the temporomandibular joint according to the technique described by McCarty and Farrar (1979) and its variation according to Leopard (1984). The animals were killed 6 weeks postoperatively. Macroscopic and microscopic examination revealed that in all rats treated according to the procedure of McCarty and Farrar (1979) the disc had completely disappeared. The underlying condyle was deformed to a mushroom shape and the cartilage of the condyle was thickened. In seven of eight rats operated on according to the technique of Leopard, the same results were observed. It is concluded that surgical repositioning of the disc according to these techniques represents a method of disc removal.

Animals

Systemic bone diseases and reduction of the residual ridge of the mandible; primary hyperparathyroidism. A preliminary report.

Twenty-five edentulous patients with established hyperparathyroidism were evaluated to establish a possible relation between extreme reduction of the height of the mandible and systemic bone loss. As an important parameter of the severity of the systemic bone loss, the level of the intact biologically active molecule of the parathormone was used. In this study no relation between hyperparathyroidism and reduction of the residual alveolar ridge could be established. In only two patients the reduction could be classified as "severe." Furthermore the level of the active, intact, circulating parathormone or the duration of the hyperparathyroidism could not be identified as an important factor in relation to the local phenomenon of reduction of the alveolar ridges.

Atrophy

Effects of experimental defects of the articular disc of the temporomandibular joint in rats.

Triangular defects were made in different locations of the disc in rat temporomandibular joints. After 3 months the following effects were observed. Central defects had become rounded without gross changes in the mandibular head. Peripheral defects were enlarged towards the centre, occasionally accompanied by condylar hyperplasia. Microscopically the cartilagenous covering of the mandibular head in all operated cases was characterized by thickening, dispersion of cells normally closely packed in the intermediate zone, and the constant appearance of a tear parallel to the surface.

Animals

Autologous versus homologous bone grafting in osteotomies, secondary cleft repairs and ridge augmentations: a clinical study.

To compare the clinical results, complications and morbidity of osteotomies, secondary cleft repairs and ridge augmentations in which frozen femoral head homologous bone or autologous bone was used, a series of 61 patients with follow-up periods of 1 to 6 years has been reviewed. Long-term clinical observation shows that, with a correct indication and surgical technique, frozen homologous bone is a good alternative to autologous bone in clinical grafting procedures.

Adolescent

Oral manifestations in Cowden's syndrome. Report of four cases.

Cowden's syndrome or multiple hamartoma and neoplasia syndrome is a hereditary disorder combining multiple hamartomas of many organs. These hamartomas are derived from ectodermal, mesodermal, and endodermal tissues and may undergo spontaneous malignant changes. Small papular cutaneous lesions and papillomatous outgrowth and papular lesions of the oral mucosa are the most predominant features of the syndrome. Since the orocutaneous lesions often precede the associated malignant degenerations, they may serve as a diagnostic signal for the probably developing neoplasia in other organs. The presence of extensive papillomatous and papular lesions in the oral mucosa combined with skin lesions should therefore alert the clinician to suspect the presence of Cowden's syndrome, the early diagnosis of which is important in order that the concomitant malignant changes might be discovered at the earliest possible moment. Four cases of Cowden's disease are presented, with emphasis on the oral manifestations of this syndrome.

Adult

Unusual healing of a fracture of an atrophic mandible. Report of a case.

Fractures of an atrophic edentulous mandible may present a serious problem in oral surgical treatment. A case is described in which a traumatic mandibular fracture, initially treated by means of a Gunning type of splint, and a subsequent spontaneous fracture on the opposite side were treated without mechanical fixation.

Atrophy

Lipoma of the tongue.

A case of an enormous lipoma of the tongue is presented. The absence of dentoalveolar changes and the complete adaption of the functions of the tongue are discussed briefly.

Adult

[Partial resection of the tongue (author's transl)].

An improved simplified technique is described for reducing the volume of the tongue by operation. A plastic support has been designed on which the tongue can be spread out symmetrically and fixed in position. Gallbladder forceps are applied to the base of the tongue to avoid hemorrhage. An initial incision is made through the whole thickness of the tongue down to the support, and a partial resectomy performed, followed by apposition of the wound edges. The results obtained with this procedure are far superior to those previously reported using other techniques: the operation takes less time and there is almost no loss of blood.

Glossectomy

Dental arch dimensions in unoperated adult cleft-palate patients: an analysis of 37 cases.

In surgically treated patients with clefts of the lip, alveolus, and/or palate, the vertical, transversal, and sagittal development of the maxilla is influenced by intrinsic, functional, and iatrogeneous (surgical) factors. To evaluate the effect of intrinsic and functional factors on dental arch development, we examined and compared unoperated adult individuals with different types of clefts. Dental casts of 37 Indonesian adults with unoperated unilateral clefts were studied: 15 subjects with unilateral cleft lip and alveolus (median age: 24 years) and 22 subjects with complete unilateral cleft of lip, alveolus, and palate (median age: 25 years). Dental arch dimensions were measured and evaluations of arch form were made. The Student's t-test showed that arch width and arch depth were significantly smaller in the complete-cleft group. There is a tendency for the smaller segment to be positioned more cranially in the complete-cleft group. Our conclusion was that subjects with an unoperated complete-cleft lip, alveolus, and palate develop an arch form that is significantly different from that in subjects with unoperated cleft lip and alveolus.

Adult