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Biomedical subjects

C Leroux

Publications and source records attributed to C Leroux.

60 records · Page 4Linked to original sources
PubMed1983

[Ultrasonic study of the carotid artery bifurcation. Comparative study with arteriography (50 cases)].

This prospective study was initiated in March 1981 and all results were compared with arteriography. The investigations were carried out with a real time Toshiba SAL 20 equipped with a 5 MHz transducer and a DUD 400 continuous Doppler ultrasonogram with a 4 MHz transducer. All patients were referred to us from the neurological and cardiac departments of our hospital. They had a wide range of conditions varying from simple paraesthesia to massive hemiplegia or from arrhythmias to syncope. The investigation always started with classical Doppler examination (12 recording points) and was followed by real time ultrasonography of the cervical vascular axes. An improved diagnostic performance with the association of Doppler + real time B mode ultrasonography was demonstrated in a previous study. The results of this study were compared with the angiographic appearances and a close correlation was observed with normal and pathological cases. In this series of 50 cases the sensitivity was 92 p. 100 and the specificity 87 p. 100. More detailed analysis of this population showed the two false negatives to correspond to two ulcerated atheromatous plaques at the carotid bifurcation. The false positive results were more difficult to interpret and may have been due to technical artefacts. However, other workers have already encountered this difficulty with surgery demonstrating the plaques detected by ultrasound. In conclusion, real time ultrasonography and Doppler are two complementary investigations which when used by the same operator can become very sensitive and reliable methods of investigation.(ABSTRACT TRUNCATED AT 250 WORDS)

Aged↗
PubMed1982

Decreased prostaglandin production in cultured smooth muscle cells from atherosclerotic rabbit aorta.

Prostaglandin synthesis in aortic smooth muscle cells originating from healthy an atherosclerotic rabbits was studied by incubating [14C]arachidonic acid with intact confluent cells and cell homogenates. In spite of a reduced 6-keto prostaglandin F1 alpha formation, no potentiating effect on the prostaglandin E2 generation occurred. Indeed, both cyclooxygenase and prostaglandin I2 synthetase activities appear to be reduced. These results suggest that an impaired arachidonic acid utilisation in aortic smooth muscle cells may be involved in the course of the atherosclerotic process.

Animals↗
PubMedDate not supplied

Messenger RNAs encoding lipoprotein lipase, fatty acid synthase and hormone-sensitive lipase in the adipose tissue of underfed-refed ewes and cows.

The mechanisms involved in the nutritional regulation of genes encoding lipogenic (lipoprotein lipase (LPL) and fatty acid synthase (FAS)) and lipolytic (hormone-sensitive lipase (HSL)) enzymes were investigated by comparing the levels of the corresponding mRNAs in the adipose tissue (AT) of underfed or underfed-refed ewes and cows. Refeeding sharply increased LPL and FAS activities (19-25- and 6-8-fold, respectively) and moderately increased (2-4 fold) the activities of glucose-6-phosphate dehydrogenase (G6PDH), malic enzyme (ME) and glycerol-3-phosphate dehydrogenase (G3PDH). Northern blot analysis revealed three LPL transcripts and a single FAS transcript in cow and ewe AT. A single HSL mRNA was detected in cow AT and two transcripts in ewe AT. Refeeding sharply increased LPL and FAS mRNA levels, while restriction slightly increased (cows) or had no effect (ewes) on the HSL mRNA levels. This suggests that nutritional factors regulate sharply the expression of LPL and FAS genes by pretranslational mechanisms, but less clearly that of HSL gene.

Adipose Tissue↗