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Biomedical subjects

C Lesser

Publications and source records attributed to C Lesser.

7 recordsLinked to original sources
PubMed1999

Ovarian decline. In the later reproductive years.

While most healthy older women who become pregnant have uneventful pregnancies and healthy babies, thousands more are unable to achieve pregnancy because of declining ovarian function. A decline in ovarian function is normal with increasing age. A woman's number of eggs steadily decreases from a peak at mid-gestation of 7 million to approximately 400,000 at puberty. Certain tests can reflect gradations in ovarian reserve status and predict a woman's potential fertility. The most important lab test is the day 3 follicle-stimulating hormone level. A constant source of frustration in fertility centers is that patients are referred to the specialty clinic too late, when diminished ovarian reserve is so marked that treatment success is severely limited. Earlier assessment of ovarian function would alter this unfortunate trend.

Adult↗
PubMed1997

Medicaid managed care policies affecting children with disabilities: 1995 and 1996.

The authors present findings from a study of State Medicaid managed care enrollment and benefit policies in 1995 and 1996 for children with disabilities. During this time the number of States serving children through fully capitated plans grew by more than one-third, and enrollment of children receiving Supplemental Security Income (SSI) payments and children in subsidized foster care increased. Most States required plans to provide all mandatory and most optional Medicaid services. Although States have begun to make noticeable improvements in their contract language concerning medical necessity and the early and periodic screening, diagnosis, and treatment (EPSDT) benefit, overall State guidance in these areas remains weak.

Capitation Fee↗
PubMed1988

Sequences beyond the cleavage site influence signal peptide function.

The earliest events in protein secretion include targeting to and translocation across the endoplasmic reticulum membrane. To dissect the mechanism by which signal sequences mediate translocation in eukaryotes, we are examining the behavior of fusion proteins and deletion mutants in cell-free systems. We demonstrate that the protein domain being translocated can have profound impact on the efficiency of the translocation process. Specifically, deletions in the mature prolactin "passenger" domain, beyond the signal cleavage site, reduce the efficiency of signal function. The effect of these deletions on signal function is observed when this signal sequence is in its normal position, at the amino terminus, and when internalized by the addition of 117 amino acids of chimpanzee alpha-globin. Alterations in the interaction of the deletion mutants with the signal recognition particle and with another component of the translocation system, signal peptidase, were observed. Our results suggest that subtle changes in sequences beyond the signal cleavage site can alter the efficiency of co-translational translocation by affecting various signal-receptor interactions.

Amino Acid Sequence↗
PubMedDate not supplied

Providing infertility care.

In recent years nurse practitioners have expanded their repertoire of ob/gyn skills to include the provision of infertility care. To minimize the stresses involved in an infertility investigation, couples benefit from a care provider who can educate them about the factors, testing, and treatments involved in infertility. They also need a provider who can support them emotionally through a work-up that touches upon the sensitive aspects of their sexuality, partner relationship, and self-esteem. Nurse practitioners have demonstrated an aptitude in providing competent medical care and health education in the context of a therapeutic relationship. Utilization of the physician/nurse practitioners collaborative team approach offers one successful model for integrating nurse practitioners into the practice of infertility.

Female↗