Biomedical subjects

C Levêque

Publications and source records attributed to C Levêque.

5 recordsLinked to original sources

PubMed2005

[Functional MR imaging and oligodendrogliomas].

The localization of functional areas obtained from functional MRI (fMRI) is useful for patients suffering from tumors contiguous to eloquent brain areas. fRMI is an efficient tool in the strategy of treatment of low grade oligodendroglioamas in the rolandic area in intact or slightly impaired patients. It can be used preoperatively to assess motor functional areas. Indeed there is a good correlation for motor cortex lesions when using comparison between fMRI and intraoperative findings. Direct integration of fMRI data into neuronavigation enables to better visualize and preserve eloquent brain areas. One must be aware of fMRI limits. It is still often used with the control of direct cortical stimulations.

Adult↗

PubMed2004

[Intradiploic parietal meningoencephalocele].

Intradiploic meningoencephalocele is rarely found in adulthood. It is thought to be postraumatic and must be differenciated from congenital encephalocele. Imaging findings, particularly with Magnetic Resonance Imaging, are useful in determining the various linings and contents of this intradiploic defect.

Aged↗

PubMed1988

Characterization of the omega-conotoxin-binding molecule in rat brain synaptosomes and cultured neurons.

omega-Conotoxin GVIA is a peptide purified from the venom of the marine snail, Conus geographus, that specifically blocks voltage-sensitive calcium channels in neurons. A mono-[125I]iodo-omega-conotoxin was prepared and specific binding to both rat brain synaptosomal membranes and cultured neurons was detected. The interaction was irreversible and the association kinetic constant k was measured at 5-7 X 10(6) M-1 s-1 in synaptosomes and at 2-4 X 10(6) M-1 s-1 on intact neurons. The binding site capacities were 650 and 60 fmol/mg of protein, respectively. No competition was detected with other calcium channel blockers or with toxins acting on Na+ or K+ channels but the binding was lowered by the divalent cations Co2+ and Ca2+. Photoaffinity experiments specifically labeled a single component with an apparent Mr of 222,000 +/- 7,000 in brain synaptosomes and 245,000-300,000 in cultured embryonic neurons.

Animals↗

PubMed1988

[Hypersensitivity pneumopathies ("bird fancier's lung") in children. Diagnostic value of bronchoalveolar lavage].

A current view of "pigeon fancier's lung" in children is reported through a familial case presenting as a severe denutrition in a 9 year-old boy. Cellular and biochemical analysis of broncho-alveolar lavage fluid is essential to proper diagnosis. Treatment is based upon the eviction of inhaled antigenic organic materials issued from pigeon's droppings, corticosteroid treatment being only additional. Pulmonary fibrosis is a rare but possible complication in the outcome of the disease.

Adrenal Cortex Hormones↗

PubMedDate not supplied

[Addition of a morphinomimetic to the continuous perfusion of 0.125% bupivacaine for peridural obstetrical anesthesia. A comparative study of fentanyl and alfentanyl].

Morphinic drugs added to epidural local anesthetic during labour enhance analgesia and obstetrical conditions. Fentanyl, 1 microgram/kg-1, is safe for the newborn. Alfentanil is of faster and shorter duration and its pharmacokinetics suggests less accumulation than fentanyl. The aim of this study is to compare Alfentanil versus Fentanyl when added to an epidural continuous bupivacaine 0.125% infusion. Two groups of parturients are constituted: group A 10 micrograms/kg alfentanil, group F 1 microgram/kg fentanyl. Pain is assessed with a 0 to 10 points scale. There are no differences between the two groups for age, weight, parity, term, initial cervical dilatation and new born weight. Analgesia begins quickly in the two groups, and is more pronounced in the group A (than in the group F (p less than 0.005). Analgesia is maintained for the whole dilatation course. Pain scores increase during expulsion but are significantly lower than the initial scores. No difference is noted as regards analgesia supplementation. Obstetrical data: labour duration, oxytocin dosage, expulsion strength, instrumental extraction rate and uterin evacuation are similar in the 2 groups. No cesarean section is observed. Neonatal status, established according to Apgar scores and then Amiel Tison neurological scales (0 to 30) respectively at 30 to 120 minutes are in the same favorable ranges: Apgar score is in all cases more than 9. The neurological score is 24 (group A) and 22.9 (group F) at 30 minutes and increases significantly at 120 minutes in the 2 groups (27 in the two groups).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗