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Biomedical subjects

C Libersa

Publications and source records attributed to C Libersa.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Effects of trimetazidine on a model of in vitro myocardial ischemia].

Cardioprotection is a new concept proposed for clinical situations as myocardial infarction and cardiac surgery. Cardioprotective effects are mainly evaluated in patients by enzymatic, electrocardiographic and sometimes histological findings. The aim of this work was to study the effects of trimetazidine on guinea-pig ventricular myocardium submitted in vitro to conditions mimicking ischaemia. A three step procedure was used: a period of stabilization of 180 minutes under control conditions, then a period of 60 minutes under ischaemic conditions, and last a replacement into control conditions perfusion (30 minutes). Trimetazidine was added in the superfusion during the last hour of stabilization and maintained during the ischaemic and the reperfusion periods. Electrical activities (micro-electrodes) and creatine phosphokinase activity in the effluent were monitorized. Trimetazidine (10(-6) M) prolonged during the ischaemic phase the duration of decremental response and improved electrical recovery during reperfusion. Moreover, trimetazidine (10(-6) M) reduced creatine phosphokinase leakage during ischaemia. The effects of trimetazidine were compared to those observed with calcium channel antagonists in the same model. Thus slowing of enzyme leakage and electrical improvement observed under trimetazidine are compatible with a so-called cardioprotective effect.

Animals↗
PubMed1986

[Ventricular extrasystole. Which should be treated and how?].

The decision of whether or not to treat a ventricular extrasystole depends in the first instance on the benign or severe nature of the disorder, and on whether there is subjacent cardiopathy. The results of 24-hour Holter monitoring, exercise tolerance tests and clinical and echographic examinations will define the pathological character of a ventricular extrasystole and will indicate any subjacent cardiopathy. Electrophysiological exploration with programmed stimulation should be reserved for so-called lethal cases of arrhythmia, such as attacks of sustained ventricular tachycardia. Ischemic cardiopathy is by far the most frequent cause of ventricular extrasystoles. The two major risks of sudden death after myocardial infarction are due to left ventricular dysfunction and repetitive and/or complex ventricular extrasystoles, as well as to attacks of ventricular tachycardia. Heart patients presenting these disorders must receive urgent treatment with antiarrhythmics. Isolated, monomorphic ventricular extrasystoles are also treated in heart patients at risk if their frequency is greater than 10 per hour, measured by 24-hour Holter monitoring. In the absence of subjacent cardiopathies, the therapeutic indications are much less well defined. Approximately five per cent of subjects in a normal population present ventricular extrasystoles, the frequency of which, however, rarely exceeds 100 per 24 hours. Repetitive phenomena are only seen in 10 per cent of cases. Attacks of ventricular tachycardia are almost never seen. Ventricular extrasystoles that develop in apparently normal hearts, but which do not fulfill the above criteria, can be considered abnormal. Nevertheless, there is no categorical proof that these ventricular extrasystoles represent any risk, notably of sudden death.(ABSTRACT TRUNCATED AT 250 WORDS)

Anti-Arrhythmia Agents↗
PubMed1986

[Continuous electrocardiographic recording with the Holter method in children. Indications and results].

There are relatively few reported studies of continuous electrocardiographic recordings by the Holter method in children. We report our experience of 296 24-hour recordings in 160 patients (average age 10.5 years), investigated for suspected or known cardiac arrhythmias. One hundred and ten patients (68.75%) had no organic heart disease and 6 patients (3.75%) had acquired lesions. Eighty-three patients (52%) were symptomatic. Sixty-three patients (39%) had normal recordings; 97 patients (61%) had a total of 126 arrhythmias. There were 45 cases of atrioventricular block, 24 cases of sinus node dysfunction, 39 cases of supraventricular arrhythmias and 18 cases of ventricular arrhythmias. Overall, 47.6% of these rhythm disturbances were diagnosed by Holter monitoring. This technique was particularly valuable in the diagnosis of arrhythmias in symptomatic patients, patients with arrhythmogenic cardiac lesions and in the detection and surveillance of postoperative arrhythmias in congenital heart disease, of pacemakers, of congenital atrioventricular block and of the chronic arrhythmias of childhood.

Adolescent↗
PubMed1976

[Pulmonary atresia (with ventricular septal defect)].

The study has been carried out on eight cases of pulmonary atresia with ventricular septal defect, this abnormality involves both valvular atresia and the stenosis of the outflow tract of the right ventricle; that means a pulmonary atresia both valvular and infundibular. The atresia is always combined with a dextroposition of the aorta, overriding the ventricular septum; often with an auricular septal defect or a patency of the foramen ovale. In two cases, other associative caridac malformations exist : either a single ventricle or an atresia of the tricuspid valve. The arterial supply to the lungs may be assured by a persistent duct or by systemic arteries, or an association of both.

Collateral Circulation↗
PubMed1975

[Arteries of the opto-peduncular region of the sheep].

The main features of the arterial plane of the base of the brain of 15 sheep are studied. Details of the topography and the importance of the manifold twigs going to the optic-peduncular formations and grey central nuclei are given also. In spite of the presence of a peculiar arterial polygon, since it has direct supply from a rete mirabile and that it depends almost exclusively on the external carotid arteries, the general diagram of the different arterial pedicles appears comparable with what was formerly pointed out in the dog (LIBERSA an coll., 1974) and even in man. It seems to be a proof of the morphological independance of the cerebral arterial system beyond the arterial polygon. The reason of the existence and appearance of the arterial plane of the base of the brain (internal carotid, external carotid, vertebral arteries) keeps an essentially functional meaning.

Animals↗