Biomedical subjects

C Librach

Publications and source records attributed to C Librach.

3 recordsLinked to original sources

PubMed1990

A class I antigen, HLA-G, expressed in human trophoblasts.

The alpha chain of the human histocompatibility antigen HLA-G was identified as an array of five 37- to 39-kilodalton isoforms by the use of two-dimensional gel electrophoresis. Both cell-associated and secreted HLA-G antigens are prominent in first trimester villous cytotrophoblasts and are greatly reduced in third trimester cytotrophoblasts. Allelic variation was not detected, an indication that HLA-G is not obviously polymorphic in cytotrophoblasts. Among the following choriocarcinoma cell lines studied, HLA-G is expressed in JEG but not in Jar or BeWo. Expression of endogenous HLA-G genes has not been found in normal lymphoid cells. Thus, HLA-G is subject to both cell type-specific and developmental regulation and is expressed in early gestation human cytotrophoblasts.

Antibodies, Monoclonal↗

PubMed1989

Maternal weight loss associated with hyperemesis gravidarum: a predictor of fetal outcome.

Over a 5-year period in our center 64 patients were hospitalized with a diagnosis of hyperemesis gravidarum. Patients were classified into two groups to determine whether weight loss was an objective predictor of pregnancy outcome. Patients whose weight loss was greater than 5% of their prepregnancy weight were classified as group A (n = 30). Patients with nausea and vomiting of pregnancy but with maintenance of at least 95% of prepregnancy body weight were in group B (n = 34). Infants in group A were significantly smaller with respect to average birth weight expressed as a percentile for gestational age: 38.11 percentile, versus 72.00 percentile for group B (p less than 0.025). Macrosomia (greater than or equal to 4000 gm) was significantly associated with group B (18% versus group A, 0%; p less than 0.025). Growth retardation (less than or equal to 10th percentile weight at birth) was significantly associated with group A (30% versus group B, 6%; p less than 0.01). Three integumentary system abnormalities (3 of 30 cases) occurred in group A compared with none in group B. Although hyperemesis gravidarum has been viewed as a positive predictor, those patients who also demonstrate weight loss and electrolyte disturbance may be a distinct entity and at greater risk for growth retardation and fetal anomalies.

Adult↗

PubMed1985

Computerized data retrieval system for colon surgery.

Good clinical practice is based on a continuous reevaluation of one's own work as compared with published standards. That which limits particularly the private practitioner from examining and publishing his data, is not the lack of desire, but the scarcity of opportunities and resources to do so. Computers as tools for data retrieval and analysis for research purposes and patient management have been available for some time. They have been of limited utility for most surgeons because of an inhibiting size and/or training period, and illogical design. The authors discuss the limitations of much of the available computer "tools," and present a system, METABASE, specifically designed for colon and rectal surgeons to use in their private practices for data retrieval and analysis.

Colon↗