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Biomedical subjects

C Lieberman

Publications and source records attributed to C Lieberman.

11 recordsLinked to original sources
PubMed1983

Comparison of imported with locally retrieved kidneys preserved by intracellular electrolyte flushing followed by cold storage.

Ice-cold intracellular electrolyte flushing followed by cold storage and economy air shipment is the cheapest method to share kidneys for transplantation. This study from 1 center compares 62 primary cadaver kidney grafts imported from other centers to 128 that were retrieved locally. Cold ischemia time was 36.4 plus or minus 8.6 hours (mean plus or minus standard deviation) in the imported group and 24.2 plus or minus 8.8 hours in the locally retrieved group. The significant increase in first week dialysis (71 versus 42 per cent) and 1-month serum creatinine nadirs (2.63 plus or minus 2.73 versus 1.78 plus or minus 1.04 mg./dl.) was explained by longer cold ischemia times in the imported kidney grafts. There were no significant differences between the 2 groups with respect to actuarial kidney graft survivals and serum creatinine levels at 1, 2 and 3 years. Intracellular electrolyte flushing followed by simple cold storage and air transportation provides kidney graft survivals and long-term kidney graft function at minimal expense when the kidneys are retrieved from beating-heart cadavers and have undergone minimal warm ischemia.

Cold Temperature↗
PubMed1983

Successful human kidney preservation by intracellular electrolyte flush followed by cold storage for more than 48 hours.

Transplantation of cadaver kidneys after flushing with an ice-cold intracellular electrolyte solution is inhibited by arbitrary time limits on cold ischemia. During the 25-month interval ending March 22, 1982 we transplanted 7 kidneys preserved by this method and cold-stored for 48.2 to 61.4 hours. Of the recipients 86 per cent required dialysis within 1 week after transplantation, the mean serum creatinine nadir within 1 month was 2.1 mg./dl. and the graft survival at 1 month was 71 per cent. The 1-year actuarial cadaver graft survival was 69.2 plus or minus 18.1 per cent. Kidneys preserved by this simple method can be transplanted successfully after 48 hours of simple cold storage.

Cold Temperature↗
PubMed1981

Human kidney preservation by intracellular electrolyte flush followed by cold storage for over 24 hours.

Many transplant teams are reluctant to accept kidneys preserved with intracellular electrolyte flushing followed by simple cold storage when preservation time exceeds 24 hr. This study from one center is a comparison of 63 primary cadaver kidney grafts preserved with Collins 2 solution flush followed by cold storage for 9 to 23 1/2 hr to 42 primary cadaver kidney grafts preserved by the same method for 24 to 44 1/2 hr. Kidneys cold-stored for over 24 hr had a significantly increased requirement for dialysis in the first week following transplantation (55% versus 30%). One-month serum creatinine nadirs and actuarial graft survivals were not significantly different. Cadaver donor methylprednisolone (30 to 60 mg/kg) 2 to 9 hr prior to kidney removal reduced the requirement for first-week hemodialysis in the kidneys cold-stored for over 24 hr (23% versus 69%, P under 0.05). A human kidney preserved by the same method and cold-stored for 61 hr was successfully transplanted into a 38-year-old myelodysplastic. Satisfactory human kidney preservation can occur with intracellular electrolyte flush solutions followed by cold storage for over 24 hr when the warm ischemia time is very short.

Cold Temperature↗
PubMed1979

Schizoaffective illness defies the dichotomy...and keeps DSM-III pondering.

Models proposed to account for patients eventually labeled "schizoaffective" are traced historically. It is demonstrated that these patients represent a distinct clinical entity, and diagnostic criteria are then applied to reevaluate the position of schizoaffective disorder in our current and future nosology. Schizoaffective illness is held to be the example, par excellence, that defies the validity of Kraepelin's original dichotomy.

Bipolar Disorder↗
PubMed1975

Social class and preschool language skill: IV. semantic mastery of shapes.

Sociolinguists have contended that children, and especially black children, from families of poverty commonly fail in school not because they have either a cognitive or language deficit but because they have a dialect problem. Being unfamiliar with standard English, they are forced to undertake a double task while learning to read. In order to test the validity of this contention, 54 Head Start and 33 nursery-school children of four years were examined with a test of shape identification. The children of Head Start identified six shapes perceptually by matching them about as well as did the nursery-school children. On the other hand, a much smaller percentage of Head Start than of nursery school named correctly all the shapes as they were indicated by the examiners or indicated correctly all the shapes when they were named by the examiners. Sex differences in semantic mastery of shapes are absent; and among the children of Head Start, race differences in semantic mastery of shapes are also absent. The deficit in semantic mastery for shapes is clearly evident, and demonstrating the existence of such deficits can be useful in guiding compensatory education.

Child, Preschool↗
PubMed1975

Social class and preschool language skill: II. semantic mastery of color information.

The four-year-old children of Head Start (two-year-classes of 90 for 1969-71 and 72 for 1971-72) performed on a test of perceptual identification approximately as well as four-year-old nursery-school children of parents predominantly of college background. On the other hand, only 28.9% and 19.4% of the children of Head Start, as compared with 87.9% and 90.2% of the children of the nursery-school pointed correctly to all six of the blocks when the examiner named the colors. Also, only 25.6% and 23.6% of those of Head Start, as compared with 81.8% and 76.5% of those of the nursery school, named the colors of all six blocks as they were designated by the examiners. Sex differences and race differences, except in the case of brown, among the children of Head Start were negligible and not significant. Somewhat more children showed semantic mastery for the warn colors, orange and red, than for the cool colors, blue and green. The finding of a deficiency in semantic mastery for such an elementary abstraction as color is highly dissonant with the contention of many students of sociological linguistics that children of poverty, and especially black children of poverty, are without cognitive or linguistic deficit, and that they fail in school only because they use a dialect differing from standard English. The finding is quite consonant with the contention that children of poverty do have a cognitive and linguistic deficit which may, and probably does, derive from the rearing conditions in their homes during the preschool years.

Black or African American↗