Biomedical subjects
Publications and source records attributed to C Lo Gullo.
Until 1970 endoscopy of the digestive tract was the only diagnostic method available. After this date, the introduction of endoscopic polypectomy enabled patients affected by these lesions to be treated, and at the same time considerably reduced their length of stay in hospital. The paper reports the results of 346 gastric polypectomies performed in 187 patients from 1974 to the present.
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From January 1970 to June 1979, 180 gastroscopies were performed in patients affected by lymphoma (168 in patients with non-Hodgkin lymphoma and 12 in patients with Hodgkin's disease). A gastric localization was evidenced in 48 patients with non-Hodgkin lymphoma (15 primaries and 33 secondaries), and no lesions were found in patients with Hodgkin's disease. The gastroscopies were accompanied by histological samples in all the cases and by cytological samples in most of them. The examination allowed a histological classification in 96% of the cases. The endoscopic aspect most frequently observed (48%) was vegetation, which was often associated with multiple ulcerations. The most frequent site (67%) was the vertical portion of the stomach. Gastroscopy was also utilized in the follow-up of 22 of the 48 patients affected by gastric lymphoma: in two of these, gastric localizations missed at other examinations were found.
Twelve minimal lesions were found over a period of 18 months at the Istituto Nazionale Tumori of Milan at the end of the radiologic, endoscopic and histologic procedures. Eleven lesions were radiologically detected, and a radiologic diagnosis of malignancy was perspectively made in 10 of the identified lesions. The radiologic aspects of minimal lesions are described. Double contrast study of the esophagus allows excellent mucosal detail and good reproduction of lesions. Simplicity and minimal discomfort for the patient justify it as a first diagnostic step for detection of neoplastic pathology.
Laparoscopy permits direct inspection of the peritoneal cavity. Its role is very important in oncology both in the adult and in the pediatric patient. From 1973 to 1985, 147 laparoscopies were performed on 137 patients, aged 2-16; indications were: definition of the nature of neoplastic disease in 8 cases, staging of known neoplasia in 132, restaging in 7. On Hodgkin's disease, splenic involvement in 8/113 cases was revealed by laparoscopy with biopsy. Histological examination was positive in 4 out of 22 cases of ovarian tumors. Morbidity was 1.2%. Although a laparotomy performed after laparoscopy has shown some false negatives, in most cases the clinical and instrumental follow-up has proved reliability of laparoscopic examination.