Lessons from a dangerous history.
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Biomedical subjects
Publications and source records attributed to C Lockie.
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Unfamiliar physical conditions and pathogens are encountered during foreign travel. Ill effects can be avoided by careful planning and this is particularly important for the elderly, children and for travellers with chronic medical problems.
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Inhibition of killer cell generation or suppression of their cytolytic capacity once formed represent fundamental mechanisms by which methylprednisolone may modulate cellular cytotoxicity in the transplant recipient. In vitro studies in mixed lymphocyte culture demonstrated that the presence of therapeutic concentrations of this agent (0.001-1 microgram/ml) during the sensitisation phase resulted in suppression of lymphocyte activation without cytolysis and marked or total inhibition of killer cell generation. A considerable individual variation in sensitivity to methylprednisolone-induced suppression was observed and killer cells once generated were resistant to this agent.