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Biomedical subjects

C Lotan

Publications and source records attributed to C Lotan.

80 records · Page 5Linked to original sources
PubMed1984

Polymorphonuclear leukocyte-associated antigenemia in measles: demonstration and significance.

An indirect immunoperoxidase technique was used for the identification of measles virus (MeV) antigen in routinely prepared peripheral blood smears. Characteristic brown immunoperoxidase staining was present in the polymorphonuclear (PMN) leukocytes in 25 of 31 children during the exanthematous stage of measles. No peroxidase staining was seen on peripheral blood smears in any of 9 children convalescing from measles or in 9 children with upper respiratory tract infections ( URTI ) without exanthema. These findings were confirmed by control studies and were reproduced by immunofluorescent staining. The data suggest that MeV antigen is localized in the PMN leukocytes during the acute stage of measles infection, and may be connected to phagocytosis of viral antigenic material by PMN leukocytes. The technique described has potential for rapid laboratory diagnosis of measles and, possibly, of other viral infections during the acute stage and before measurable amounts of antibodies are produced.

Acute Disease↗
PubMed1982

The reaction of human SLE antibodies with native, single stranded RNA: analysis of nucleotide sequence specificities and correlation with Sm and nRNP activities.

The antigenic specificities of RNA reactive IgG autoantibodies from three individual human SLE sera and pooled NZB/NZW mouse serum were studied by competition reactions with synthetic co-polymers and heteropolymers of varying nucleotide compositions. Although minor differences in the individual binding patterns were noted, the RNA reactive immunoglobulins showed a clear preference for G, C and G,C,U containing RNA sequences. All three SLE sera had Sm or RNP activities with rabbit thymus extractable nuclear antigen (ENA). Conversely, all SLE sera that were selected on the basis of their positive ENA reaction could also bind free, single stranded RNA. These results suggest that the autoimmune response to RNA in human and murine SLE is restricted to one or a very few antigenic determinants. They also raise the possibility that autoantibodies to native RNA in SLE sera are partly responsible for ENA reactivity.

Antigen-Antibody Complex↗
PubMedDate not supplied

Guide wire entrapment during PTCA: a potentially dangerous complication.

The tip of a "high-torque" floppy guide wire became entrapped in a coronary artery during elective PTCA in four patients. In two it was removed through the guiding catheter, in the third an operative intervention was needed in order to free the wire, and in the fourth the remnant was left in situ. Interventional cardiologists should be aware of this potential complication.

Adult↗
PubMedDate not supplied

Extent of measles hepatitis in various ages.

To assess extent of hepatic involvement in measles, we evaluated prospectively 144 patients (ages 0.2 to 43 years) during an outbreak. Liver function parameters (AST, ALT, serum gamma-glutamyl transpeptidase and bilirubin) were determined on presentation and at 2 and 4 weeks. The study comprised 52 pediatric (less than or equal to 14 years) and 92 adult patients. Liver dysfunction was evident quite often (56 to 66%) in adult patients. However, in the pediatric age group, these abnormalities were less frequent and less extensive. Moreover, a significant correlation was noted between age and each of the following parameters: AST (r = 0.61), ALT (r = 0.56) and serum gamma-glutamyl transpeptidase (r = 0.39). In all subjects all parameters normalized after 2 to 4 weeks. The data presented suggest that hepatic dysfunction in measles is probably not rare and is more frequent and more extensive in adults. However, these abnormalities seem to be subclinical, self-limited and probably with no long-term sequelae.

Adolescent↗
PubMedDate not supplied

Age- and gender-related differences in success, major and minor complication rates and the duration of hospitalization after percutaneous transluminal coronary angioplasty.

This report describes the effect of age and gender on the results of balloon angioplasty using current technique and indications. A consecutive group of 2,067 patients who underwent angioplasty at a single institution after 1990 is described. Angioplastic success was 92.2% and similar among men and women and the various age groups. Sixteen patients (0.8%) died, and mortality among women was significantly higher (1.4 vs. 0.6%, p < 0.001). There were no age or gender differences in the rate of Q-wave myocardial infarction and the need for coronary artery bypass. Minor complications such as groin complications (10.5% women, 5.0% men; p < 0.001) and infections (6.4% women, 3.7% men; p < 0.05) were more common in women, and as a result the duration of hospitalization after angioplasty was longer. The length of hospitalization after angioplasty was longer with advanced age, mainly as a result of higher groin complications (p < 0.001), infections (p < 0.01) and renal failure (p < 0.05). We conclude that using current indications and technique, angioplasty can be performed safely with a high success rate. Mortality is higher among women. The length of hospitalization after angioplasty is longer in women and, at advanced age, due to higher rate of minor complications.

Age Factors↗
PubMedDate not supplied

Acute septal myocardial infarction diagnosed by endomyocardial biopsy in a heart transplant recipient.

We describe an unusual case of acute septal myocardial infarction in a heart transplant recipient. The clinical presentation was most suggestive of acute rejection; the correct diagnosis was first made by endomyocardial biopsy and was then verified by coronary angiography. Acute myocardial infarction should be included in the differential diagnosis of acute rejection after heart transplantation and included among the possible diagnoses made by endomyocardial biopsy in these patients.

Biopsy↗