PubMed Health⌕ Search

Biomedical subjects

C Lucantoni

Publications and source records attributed to C Lucantoni.

14 recordsLinked to original sources
PubMed1996

[Silent cardiopathy and aging. Assessment of pain threshold and tolerance].

The increase in pain threshold is one of the most significant hypothesis regarding the origin of silent ischaemic cardiopathy. The relations between silent ischaemia and aging aren't clear, although age is considered a risk factor in this pathology, in relation to a supposed peripheral neuropathy. In our study we evaluated the trend of pain threshold and of pain tolerance in subjects affected by silent ischaemic cardiopathy; we especially considered the role of aging. We studied 15 subjects with silent ischaemic cardiopathy and 15 with symptomatic cardiopathy; we evaluated the pain threshold and tolerance in three points using short and low frequency transcutaneous electrical impulses. All subjects were male; the exclusion criterion was a high level of anxiety and depression. Pain threshold values were measured with the same method in 40 healthy subjects, 5 per each decade and ranged from 10 to 90 years. Our data show a significant difference in pain threshold and tolerance between subjects affected by silent and non silent cardiopathy (33.9 +/- 12.9 mA vs 25.0 +/- 12.6 mA: p = 0.001 in the comparison of thresholds, and 66.8 +/- 20.9 mA vs 45.0 +/- 21.8: p = 0.000 in the comparison of tolerances). Regarding the higher significance of our data, compared with other studies, we considered the importance of our particular stimulation method and of the uniformity of the studied group. We didn't note any correlation between pain threshold and age. These data suggest that the differences evident between subjects with silent and symptomatic cardiopathy are linked to a different modulation of central pain perception uncorrelated with age.

Adult↗
PubMed1994

Chorea due to hyperthyroidism in old age. A case report.

The authors discuss the case of an elderly female patient with thyrotoxicosis and chorea. T3 and T4 serum values were high. Since the chorea disappeared with euthyroidism but reappeared whenever there was a further increase in T3 and T4, its relationship on hyperthyroidism and its reversibility are clearly demonstrated. The chorea therefore appears to be another clinical condition present in hyperthyroidism.

Aged↗
PubMed1994

[Reflex sympathetic dystrophy of the upper limb secondary to barbiturate treatment. A report of 3 cases and a review of the literature].

The authors describe three cases of reflex sympathetic dystrophy of the upper extremity associated with barbiturate therapy and evidence their common clinical aspects and differences. The most recent knowledge and the most important literature relating to this subject are also reported. On the basis of these, personal observations are discussed and some pathogenetic hypotheses formulated.

Aged↗
PubMed1993

[Electrophysiologic diagnosis of carpal tunnel syndrome in patients with diabetes mellitus].

The authors evaluated 406 patients affected by carpal tunnel syndrome diagnosed by clinical and electromyographic data. Diabetes mellitus was recognized in 57 subjects. The others constituted the control group. The severity of the syndrome was similar in both groups. Also similar was the interval between onset and clinical diagnosis. Such parameters and the severity of the syndrome showed no modification with age in the diabetic group. In the control group, carpal tunnel syndrome was more pronounced in the aged patients, presumably for the longest latency of disease. Carpal tunnel syndrome onset was later in diabetic subjects compared the control. At lastly we found a prevalence of bilaterality in diabetics, and an M/F rate comparable in both groups, as described by other authors.

Adult↗
PubMed1992

Clinical and electromyographic evidence of carpal tunnel syndrome in a hypertensive patient with chronic beta-blocker treatment.

We describe a case of carpal tunnel syndrome (CTS) in a hypertensive man on long term treatment with a beta-blocker, propranolol. The clinical and instrumental findings, including MRI at the wrist, excluded all other possible causes of CTS. The improvement in symptoms and electromyographic findings on discontinuation of the drug suggested that the CTS may have been related to the beta-blocker therapy.

Adrenergic beta-Antagonists↗
PubMed1992

[Carpal tunnel syndrome secondary to repetitive microtrauma. The clinical and electromyographic aspects].

The authors describe 20 cases of carpal tunnel syndrome (cts), caused by repetitive microtrauma at work. The clinical and electromyographic data are compared with a control group (406 pt affected by non traumatic cts). In the control group, the syndrome appeared more frequently in the right side (mostly in men), in relation to the manual dominance. These data suggest that the importance of "physiological traumatism" is decisive in the pathogenesis of the syndrome. Patients affected by microtraumatic stc show a better EN-Graphic pattern versus the control group, likely imputable to a earlier diagnosis.

Adolescent↗
PubMed1991

Biochemical effects of urapidil on red cell membrane ion transport systems in a population of elderly essential hypertensives.

The aim of our work was to verify the effect of urapidil on membrane ion transport systems. This was a randomized, double-blind, cross-over study which evaluated the clinical and biochemical effects of urapidil (30 mg twice daily in comparison with placebo) in a group of 10 elderly hypertensive patients (3 male, 7 female ranging from 68 to 90 years, mean age 79.2 +/- 7.6 years). For the evaluation in fresh erythrocytes of principal ion transport systems (cotransport Na+/K+, countertransport Na+/Li+, Na+/K+ ATPase pump. intracellular Na+ and K+) we used the nystatin technique. We found that urapidil activated the red cell membrane ions cotransport system (basal values: 83.7 +/- 50.3 mumol Na+ RBC 1-1.h-1, after 1 month of urapidil therapy: 181.5 +/- 89.3 mumol Na+ RBC 1-1.h-1) (P less than 0.01), without significant changes in the other biochemical parameters evaluated. Our data suggest that one of the mechanisms of the urapidil antihypertensive effect could involve an increase in the membrane sodium cotransport system.

Aged↗
PubMed1983

On the interrelationship between serum parathormone levels and osteoporosis in old humans.

Seventy-eight persons (51 females, 29 males) of an average age of slightly higher than 65 yr were studied, suffering mostly from cardiovascular diseases or various degrees of osteo-arthropathies. The so-called compacta index was calculated from the values of the external and internal diameters measured radiologically in the central region of the left-hand second metacarpus. Serum parathormone levels were assayed by radioimmunological methods. Furthermore, a series of other parameters regarding the composition of the serum have been recorded. Statistical analysis of the data obtained revealed no correlation between the serum parathormone level and the compacta index actually found in the patients. Therefore, one can conclude that the senile bone-loss has no common aetiopathogenetic basis with the uraemic osteodystrophies or all other forms of increased parathormone production. The serum levels of parathormone did not increase with aging; on the contrary, as it is known for other hormones, they display a decreasing tendency. However, this decrease proved to be statistically insignificant. Otherwise, the age- and sex-related alterations of the bone mass observed in the patients studies agree with the general knowledge.

Adult↗
PubMedDate not supplied

Course of pain sensitivity in aging: pathogenetical aspects of silent cardiopathy.

Aging is often considered a risk factor for silent ischemic cardiopathy. Using endermic electric stimuli, we assessed the course of pain threshold and pain tolerance in 23 male subjects affected by silent myocardial ischaemia, and in 20 male subjects with symptomatic cardiopathy; we also attempted to define the role played by age. Values of pain threshold were assessed using the same method in a group of 40 healthy subjects, five for each age decade, between 10 and 90 years. Our data show a significant difference in pain threshold and tolerance between subjects with silent and symptomatic cardiopathies (34.7 +/- 12.6 mA versus 25.2 +/- 12.5 mA: P < 0.001 for the threshold and 68.5 +/- 21.2 mA versus 46.0 +/- 22.3: P < 0.001 for tolerance). The fact that the significance of our results is superior to that of other studies may be due to the particular method of stimulation used and to the uniformity of the sample studied (sex, age, exclusion of subjects with anxiety-depressive symptoms). No difference was found in pain threshold as regards age. It seems probable that the difference found between subjects with silent and symptomatic cardiopathies is due to the different modulation of the perception of pain at a central level, independently of the age factor.

Journal Article↗
PubMedDate not supplied

[Profile of thyroid hormones in aging: evaluation of a hospitalized elderly population].

The aim of the study is to evaluate thyroid serum levels in a geriatric community to confirm the presence of a low T3 syndrome during normal ageing. The authors consider 413 subjects (125 male and 288 female) admitted to our Geriatric Division. The group affected by thyroid and extrathyroid disease (such us malnutrition, diabetes mellitus, renal failure, etc.) was withdrawn. In the selected patients (271) was operated a statistical evaluation to correlate the hormonal parameters (T3, T4, TSH, FT3, FT4) with age and sex. According to international literature, we confirm a progressive T4 and FT4 reduction (p less than 0.05) during ageing, both in male and in female. These data range within normal values. On the contrary, TSH shows no modifications with age and sex. Unlike all other parameters, T3 presents a more evident decrement with age, confirming a low T3 syndrome.

Aged↗