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C Luderschmidt

Publications and source records attributed to C Luderschmidt.

At least 55 records · Page 3Linked to original sources
PubMed1983

[The sterile Behçet pustule: a typical skin manifestation of the Behçet syndrome].

Solitary pustules were excised from five patients with Behçet's syndrome and examined histologically, immunohistologically, and--in one case--by immunoelectron microscopy. Histologically the changes were largely confined to the venules of the middle and lower corium. The endothelium was swollen, in part the vascular walls were destroyed. In the perivascular spaces there was round-cell infiltration, mixed with numerous neutrophilic granulocytes, some of them disintegrated. Immunofluorescence-microscopy revealed perivascular deposition of complement C3 and C1q. In fresh lesions there were also IgG or IgM precipitates. Immuno-electron microscopy also demonstrated complement C3 subendothelially. Fibrin deposition and disintegrating neutrophilic granulocytes marked the leukocytoclastic vasculitis. Taken together the findings indicate that an immune-complex vasculitis takes part in the pathogenic mechanism of pustule formation in Behcet's syndrome.

Behcet Syndrome↗
PubMed1983

Steroid hormone receptors and their relevance for sebum production in the sebaceous gland ear model of the Syrian hamster.

We determined the capacity of steroid hormone receptors in the sebaceous glands of intact nontreated, castrated, with testosterone substituted castrated male, intact female, and intact with testosterone substituted female animals using the animal ear model of the Syrian hamster. The steroid hormone binding capacity was compared with the sebaceous gland areas and sebogenesis. Intact male animals showed large sebaceous follicles, a high sebogenesis rate, and high capacity for sexual hormone binding proteins. In castrated males, the sebaceous gland areas and sebogenesis were both diminished, and androgen and estrogen receptors were decreased. When the castrated males were substituted with testosterone propionate, the sebaceous glands showed large volumes, high sebum production, and androgen binding activity again. In female animals having small sebaceous follicles and a low rate of sebogenesis, testosterone propionate enlarged the sebaceous glands and increased sebogenesis and the capacity of androgen binding. One can conclude from these data that testosterone is not only the main hormone for sebum production but also induces the synthesis of its own receptor.

Animals↗
PubMed1982

[Clinical value of bronchoalveolar lavage in progressive systemic scleroderma (author's transl)].

As an enlargement of conventional diagnostic methods the cell spectrum of bronchoscopically obtained bronchoalveolar lavage was investigated in 10 patients with progressive systemic scleroderma. Two cases showed marked lymphocytosis, one increased numbers of granulocytes, two patients had marginally increased percentages of inflammatory cells. Four of these patients were in a progressive active phase of scleroderma with humoral inflammation signs and round cell infiltrates of the skin. In contrast, the lavage cell picture of the other five patients was unremarkable. One of these had advanced pulmonary fibrosis, however without signs of progression. The results show that the lavage cell pattern reflects the acute phase with cellular inflammation of lung parenchyma disease such as occurs in progressive systemic scleroderma. Staging of pulmonary organ manifestation in progressive systemic scleroderma can be markedly improved by low-risk bronchoalveolar lavage.

Adult↗
PubMed1982

Inhibition of sebaceous gland activity by spironolactone in Syrian hamster.

In the animal model of the Syrian hamster the antiandrogenic action of spironolactone on the sebaceous glands of the ventral side of the pinna was examined. Spironolactone reduces both labeling index and cross-sectional surface area of sebaceous glands significantly in a dose-dependent manner. Equally there was a significant decrease in serum testosterone levels in spironolactone treated animals. Our results seem to justify clinical studies with spironolactone in patients with hirsutism, seborrhea, and possibly acne vulgaris.

Animals↗
PubMed1981

Scleroderma fibroblasts: some aspects of in vitro assessment of collagen synthesis.

Fibroblasts were cultured from skin biopsies of patients with systemic sclerosis in different stages of the disease. In vitro synthesis of collagen was checked after a pulse with tritiated proline. The ratio between type I and type III collagen was normal in all patients. Six of seven cultures derived from patients in the active state showed an increased synthesis of collagen relative to other proteins. Addition of serum (normal and diseased) to the culture medium did not stimulate synthesis of collagen in any culture with normal collagen synthesis.

Adult↗
PubMed1981

[Apthae: histologic, immunofluorescent and immuno--electron microscopy study of their pathogenesis].

The present study was done to elucidate the pathogenesis of aphthae in recurrent oral ulcers and Behcet's disease. Histologically, early stages of aphthae showed a predominantly neutrophil infiltrate and leukocytoclasia in the vessel walls, as well as extravasates of erythrocytes. In later stages, also histiocytes and lymphocytes appeared. By direct immunofluorescence technique, 30 of 34 patients showed perivascular precipitates of C3 and Clq, eight patients in addition, IgM and IgG. Remarkably, band-like fine granular precipitates of C3 were present in the basement membrane zone. By immunoelectronmicroscopy, C3 was demonstrated in fine subendothelial granules of the vessel walls and of the epithelial basement membrane below the lamina densa. There were no fundamental differences between the aphthae of recurrent oral ulcers and Behcet's disease. Our findings indicate, that an immunecomplex vasculitis is involved in the pathogenesis of aphthosis.

Behcet Syndrome↗
PubMed1980

Immunofluorescence analysis of collagen, fibronectin, and basement membrane protein in scleroderma skin.

Scleroderma skin and the subcutaneous tissue was studied by indirect immunofluorescence with specific antibodies against interstitial collagens and procollagens, against fibronectin and against the basement membrane proteins Type IV collagen and laminin. Staining for Type I procollagen and fibronectin was distinctly increased in the lower dermis and subcutaneous tissue. When compared with normal skin the data suggests that fibrosis may start around capillaries and in close proximity to adipose cells. Additional changes in the distribution to Type IV collagen and laminin were found in some patients and probably reflect the alterations in small blood vessels.

Adult↗
PubMed1980

[Heterozygous Fabry's disease. Case report with electron microscopic studies].

Fabry's disease is an inborn error of sphingolipid metabolism. The lysosomal hydrolase, alpha-galactosidase, is deficient. The full spectrum of symptoms (diffuse angiokeratoma, alpha-galactosidase deficiency) is only seen in males, who are always hemizygous. The heterozygous females may be asymptomatic and the enzyme activity can be normal. Such a case is reported. The diagnosis of this case was made by electron microscopic findings of the characteristic cellular lipid-inclusions within endothelial, perithelial, smooth muscle, and nerve sheath cells. The electron microscopic findings are a valuable clue to the diagnosis in these problem cases. The early diagnosis of female conductors is important for genetic counseling.

Age Factors↗
PubMed1980

[Keratosis palmaris et plantaris areata Siemens. Therapeutic experiments with aromatic retinoid Ro 10-9359].

A family is presented with keratosis palmoplantaris areata Siemens in four generations. The hyperkeratotic plaques did not responds satisfactorily to treatment with aromatic retinoid Ro 10-9359. Therapy had to be discontinued because of side-effects. Proliferation-retention hyperkeratosis without epidermolytic features may not respond properly to aromatic retinoid treatment.

Adult↗