Motor performance and motor learning in Lurcher mice.
In adult Lurcher mice virtually all cerebellar Purkinje cells have degenerated as a direct consequence of mutant gene action, providing a natural model for studying the effect of cerebellar cortical lesions on the generation of compensatory eye movements. Lurcher mice possess both optokinetic (OKR) and vestibular (VOR) compensatory reflexes. However, clear differences were observed in control of the OKR consisting of a large reduction in gain and a moderate increase in phase lag. Minor differences were also observed in the VOR in that gain and phase lead of the reflex were both increased in Lurcher animals. Subjecting Lurcher animals to eight days of visuovestibular training tested the assumption that increased VOR gain reflected an adaptive mechanism within remaining brainstem oculomotor pathways to compensate for the reduced OKR. Contrary to control animals, Lurcher animals were unable to modify either VOR or OKR in the course of training and therefore confirmed that an intact cerebellum is indispensable for the implementation of adaptive modifications to the oculomotor system.