The influence of family and friends' basic conditioning factors and self-care agency on unmarried teenage primiparas' engagement in contraceptive practice.
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Adolescent↗
Biomedical subjects
C M Andrews
Publications and source records attributed to C M Andrews.
The breathless FGF receptor homolog, a downstream target of Drosophila C/EBP in the developmental control of cell migration.
To investigate the molecular mechanisms responsible for the temporal and spatial control of cell movements during development, we have been studying the migration of a small group of follicle cells, called the border cells, in the Drosophila ovary. Timely initiation of border cell migration requires the product of the slow border cells (slbo) locus, which encodes the Drosophila homolog of the transcription factor C/EBP. Here we report evidence that one target of C/EBP in the control of border cell migration is the FGF receptor homolog encoded by the breathless (btl) locus. btl expression in the ovary was border cell-specific, beginning just prior to the migration, and this expression was reduced in slbo mutants. btl mutations dominantly enhanced the border cell migration defects found in weak slbo alleles. Furthermore, C/EBP-independent btl expression was able to rescue the migration defects of hypomorphic slbo alleles. Purified Drosophila C/EBP bound eight sites in the btl 5' flanking region by DNAse I footprinting. Taken together these results suggest that btl is a key, direct target for C/EBP in the regulation of border cell migration.
Animals↗
Methods for assessing drug use prevalence in the workplace: a comparison of self-report, urinalysis, and hair analysis.
A random sample of 1,200 employees of a steel manufacturing plant were randomly assigned to four different self-report methods of assessing illicit drug use: 1) Individual interview in the workplace, 2) group-administered questionnaire in the workplace, 3) telephone interview, and 4) individual interview off the worksite. Urine specimens were collected and analyzed on all 928 subjects participating in the study, and hair analysis was conducted on 307 of the subjects. Although self-reports produced the highest drug use prevalence rate, analyses combining the results of the three assessment methods showed that the actual prevalence rate was approximately 50% higher than the estimate produced by self-reports. The group-administered questionnaire condition produced prevalence rates that were roughly half those of the other self-report methods. The findings cast doubt on the validity of self-reports as a means of estimating drug use prevalence and suggest the need for multiple assessment methods.
Adolescent↗
Alcohol self-administration in a nonrestricted access situation with alcohol-preferring (P) rats.
Genetic variables have been implicated as contributing factors in the development of alcoholic behavior. Rats bred selectively for alcohol preference have been used in laboratory studies to investigate the role of such variables. In the present study, rats from the alcohol preferring (P) line were placed in operant chambers in which food pellets, water, and 10% ethanol (v/v) were available continuously for 23 hr/day. Food pellets (45 mg) were presented on an FR 1 schedule of reinforcement, while ethanol was presented in a 0.1 ml dipper on an FR 4 schedule of reinforcement. Water was available in a drinking tube with licks monitored by a drinkometer. Data were analyzed in terms of both total daily intakes and computer defined bouts. The P rats showed greater daily ethanol intakes compared with Long-Evans (LE) animals previously studied under similar access conditions. The major difference in intake was a result of the P rats having a greater number of daily ethanol drinking bouts, while having only a slight increase in individual bout size. These data indicate that genetic selection for ethanol preference may result in the regulation of ethanol intake by means of changes in the frequency of ethanol drinking bouts but not by changes in bout size.
Alcohol Drinking↗
Immunization of merino ewes with a synthetic inhibin peptide or with preparations obtained from bovine and porcine follicular fluids by immunoaffinity chromatography result in different effects on ovulation rate and on plasma gonadotrophin concentrations.
Ewes were immunized with either a synthetic peptide (peptide 1-32) that has an amino acid sequence identity with the first 32 amino acids at the amino terminal of the alpha-subunit of porcine inhibin, or with bovine or porcine monoclonal antibody purified inhibin (bMPI and pMPI respectively), obtained by immunochromatography from follicular fluids. The peptide 1-32 was conjugated to albumin before use. Peptide 1-32 and bMPI increased ovulation rate and number of follicles (greater than or equal to 5 mm diameter). Although bMPI increased plasma FSH concentration the peptide did not. pMPI had no effect on ovarian activity but markedly elevated both plasma FSH and LH concentrations. The plasma LH concentration was lowered in ewes immunized with peptide 1-32. It appears, therefore, that ovulation rate can be increased following increased plasma FSH concentrations at luteolysis or in the absence of such an increase. Conversely, greatly increased plasma gonadotrophin concentrations at luteolysis (pMPI) were not followed by an increase in ovulation rate. Antibodies in the plasma of ewes immunized with peptide 1-32 and bMPI bound to iodinated synthetic human inhibin alpha-chain 6-30 peptide. The results suggest that ovulation rate is at least partly determined by intraovarian factors.
Animals↗
Maternal position, labor, and comfort.
The purpose of this study was to determine if women who assumed upright positions during the phase of maximum slope would have a shorter phase of maximum slope in their labor and experience more comfort than women who assumed recumbent positions. Forty laboring women were randomly assigned to either an upright or recumbent position group. Subjects assumed the positions of their assigned group during the phase of maximum slope in their labor (cervical dilatation from 4 cm to 9 cm). Every hour during the phase of maximum slope, each subject was examined vaginally to determine her cervical dilatation and assessed for her level of comfort using the Maternal Comfort Assessment Tool. Women in the upright position group had a significantly shorter phase of maximum slope in labor, but did not significantly differ in comfort level from women in the recumbent group. Newborn Apgar scores were not significantly different between the two groups. Nurses need to be aware that the upright labor positions have the distinct advantages of facilitating efficient uterine contractions and reducing the duration of the phase of maximum slope in labor, with no increase in the discomfort experienced or adverse effect on newborn well-being.
Adolescent↗
Nursing intervention to change a malpositioned fetus.
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Adult↗
Changing fetal position through maternal posturing.
Two completed studies and a study in progress have addressed the question whether maternal posturing can produce the rotation of a fetus from a posterior or transverse position to the optimal anterior position. There are clinical problems associated with a malposition and also with the therapeutic procedures used to correct the malposition. Maternal posturing is considered safe, simple, economic, and noninvasive. There is a sound rationale for the choice of the hands and knees posture and the variations used to facilitate fetal rotation. Two studies indicate the effectiveness of maternal posturing. The physical theories of gravity, buoyancy, and friction are used to explain the postures, the fetus, and fetal rotation. The results of the second study are explained with the same physical theories. A current study about maternal postures and fetal position is in progress.
Biophysical Phenomena↗
Success and failure in the treatment of solid tumors. 3. "Cure" of metastatic Lewis lung carcinoma with methyl-CCNU (NSC-95442) and surgery-chemotherapy.
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Animals↗
Changing fetal position.
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Delivery, Obstetric↗
Use of pelvic tilt exercise for ligament pain relief.
The purpose of this study was to test the effectiveness of a pelvic (hip) tilt exercise in relieving ligament pain during pregnancy. A multiple pain measurement approach was used. The intensity of ligament pain was decreased as indicated by scores on three of four pain intensity measures. The duration of ligament pain also was reduced, although not significantly. Mean scores on all measures of ligament pain intensity, duration, and frequency were lower after the exercises were initiated. Verbal reports from subjects indicated that they had received effective pain relief from the exercise. Thus, pelvic (hip) tilt exercise appears to be effective in reducing ligament pain intensity and, to a lesser extent, pain duration. As a nurse-midwifery strategy, this exercise promotes patient/client comfort and facilitates self-care in the relief of ligament pain during pregnancy.
Exercise Therapy↗
Ethanol drinking patterns in a continuous-access operant situation: effects of ethanol concentration and response requirements.
Rats, initiated to self-administer ethanol with either a sucrose-substitution procedure or a secondary-conditioning procedure, were maintained in a continuous-access environmental system in which operant lever press responses were required to receive 10% ethanol and food reinforcement. Water available from a drinking tube was electronically monitored to detect licks. Total daily consumption and patterns of food, water, and ethanol responding were analyzed under conditions in which the concentration of ethanol presented as a reinforcer was either 10% or 20%, and the response requirement for ethanol reinforcement was either a fixed ratio 4 schedule or a fixed ratio 1 schedule. Either increasing the ethanol concentration or decreasing the response requirement resulted in an increase in total daily ethanol intake. There was no significant difference between initiation procedures. These results are similar to observations in studies using a limited-access operant situation. This increased ethanol intake resulted from a complex alteration in the daily ethanol drinking pattern. The greatest ethanol intakes were observed when both the ethanol concentration was increased and response requirement was decreased. This was predominantly the result of increasing the number of ethanol drinking bouts per day when the response requirement was decreased, and by decreasing individual bout size by less than half when the ethanol concentration was doubled. These studies indicate that concentration of the ethanol presented as the reinforcer and the response cost required for reinforcement are involved in regulating ethanol consumption in the continuous-access condition. Type of initiation did not appear to interact with these variables.
Alcohol Drinking↗
Effects of morphine on acquisition and maintenance of ethanol and water intake patterns in rats.
Two experiments were conducted to assess the effects of chronic subcutaneous injections of morphine (1.0 mg/kg) or saline on the pattern and amount of sweetened ethanol and water intake in fluid restricted Long-Evans rats. Following daily injections, 2-h two-bottle choice tests were conducted with water and an ethanol solution (15% ethanol v/v in 5% sucrose w/v). During a 20-day acquisition phase (Experiment 1), ethanol intake patterns and amounts did not differ between saline (n = 6) and morphine (n = 6) groups. Both groups exhibited ethanol intake patterns that decreased exponentially throughout the session suggesting control by fluid restriction procedures. Morphine decreased water intake during initial periods of each session and increased intake during later periods. In Experiment 2, morphine and saline injections were reversed across three phases with the same rats. Morphine increased total ethanol consumption during the first few days of each 15-day phase, but the groups did not differ thereafter, and the initial increases produced no statistically significant group differences. Additionally, morphine augmented ethanol intake in early portions of sessions, while water intake was decreased and increased during early and later portions of each session, respectively. Analysis of the data from the last 5 days of each phase indicated that, when injected with morphine, the group which received saline during acquisition consumed significantly more ethanol solution than the group injected with morphine during acquisition. The effect on patterns of water and ethanol intake were observed, regardless of the drug injected during acquisition.(ABSTRACT TRUNCATED AT 250 WORDS)
Alcohol Drinking↗
Nursing, maternal postures, and fetal position.
The objectives of this study were to (a) determine if a safe, simple, and economic nursing procedure--maternal posturing--would result in the rotation of a fetus in the posterior or transverse position to the optimal anterior position and (b) evaluate the relative effectiveness of a series of maternal postures for facilitating anterior fetal rotation. One hundred healthy women at term pregnancy were randomly assigned to four treatment and one control posture for a 10-minute period. At two nurse-midwifery clinics, one certified nurse-midwife postured the subjects and one midwife measured the dependent variable (fetal position) with Leopold's maneuvers. Hypotheses I-IV, which predicted that the four rotation postures would have a greater proportion of anterior fetal rotations than the control posture, were supported (p less than .000). Essentially all four postures were effective and there was little difference between the treatment postures. A second posturing was performed to determine if an additional 10 minutes in a treatment posture would result in an anterior fetal position. There was a greater proportion of anterior fetal rotations with the four rotation postures than the control posture. The Sims posture was used as a maintenance posture for anterior positions, and was successful when done on the opposite side of the fetal back. The theoretical explication of how maternal postures effect fetal rotation remains sound.
Adult↗