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Biomedical subjects

C M Büsing

Publications and source records attributed to C M Büsing.

At least 19 recordsLinked to original sources

Unilocular toxoplasmosis simulating intracerebral tumor.

Toxoplasmosis is a common infection with increased incidence in patients suffering from AIDS. In this paper we report a rare case of toxoplasmosis without evidence of AIDS: The patient had a singular tumor-like lesion in the right parietal lobe in CT and MRI. In neurosurgical intervention no tumor was found. Finally, different histopathological examinations led to the diagnosis of toxoplasmosis. Diagnostic and therapeutic regimes in patients with suspect tumor-like lesions should be discussed.

Aged↗

[The preoperative marking of nonpalpable breast lesions: the technic and results].

189 non-palpable breast lesions in 182 patients were localized using conventional mammographic apparatus, a wire grid compression plate and a cannula with a hooked mandrin. The technique of the examination for defining the lesion in three planes and fixation of the lesion with the wire is described. In 173 instances (91.5%), the lesion was found at the first biopsy and subsequent biopsies were necessary on only 24 occasions. One lesion (0.5%) was missed completely. 47 carcinomas were found (24.9%) and the incidence of malignancy increased from 14.3% to 33.3% during the series. The mean ratio defining the size of the biopsy and the size of the lesion was 3.3 and indicates good preservation of breast tissue. Radiographs of the specimen taken with compression showed 186 lesions (98.4%). The method, which is comfortable for the patient, provides satisfactory detection and localization of the lesions; results are similar to those of stereotactic methods but this method is quicker and much less expensive.

Adult↗

Biomechanical considerations on some postoperative problems of directly anchored total hip replacements.

Uncemented total hip replacements have resulted in a higher incidence of postoperative complaints than cemented ones. The theoretical explanation of these not well defined discomforts is based on the differences of the stress and strain fields around the distal portions of the femoral components. While the noncemented stems are press-fitted and most of them tapered distally, thus creating hoop stresses and strains in the surrounding cortical bone, the shrinkage of the cement prevents these mechanical irritations. The relatively sudden disappearance of these discomforts within the first 2 postoperative years is attributed to the shift of the main zone of load transmission from the distal to the proximal portion of the stems following bone remodeling.

Biomechanical Phenomena↗

[Gangliocytic paraganglioma of the duodenum].

In a 49-year-old patient who was investigated because of abdominal complaints we found a polypoid tumor in duodenum near the papilla of Vater. The histological investigation after endoscopical polypectomy showed the rare case of a gangliocytic paraganglioma. After complete endoscopical removal no further intervention is necessary.

Duodenal Neoplasms↗

[Polyglactin 910 (Vicryl) net in myringoplasty. An animal experiment and clinical study].

According to studies by Dociu (1978), the resorption of Vicryl sutures causes only a slight foreign-body reaction in the back musculature of rats. Similarly, in experimental studies by Bowald et al. (1978) Vicryl mesh is reported to be an excellent material for use in the reconstruction of arteries; the chief virtue attributed to it is that it promotes cell proliferation during the healing process, and so promotes the growth of new arterial walls. Stimulated by Dociu's and Bowald's favourable results, we decided to study the influence of an impregnated, and hence stiffer, Vicryl mesh on the outcome of myringoplasties. Myringoplasties were performed on both ears of 15 cats. One ear drum of each cat was reconstructed with fascia and Vicryl mesh, the other (= control) ear drum with fascia only. In addition, myringoplasties with autologous fascia and Vicryl mesh were performed on 18 patients. The absorption of Vicryl mesh results in a temporary but pronounced foreign-body reaction. In consequence, the tympanic membrane temporarily thickens and is thoroughly vasculated. According to our findings Vicryl mesh does not promote the growth of a new tympanic membrane. In our patients we noticed pulpy swelling of the fascia after myringoplastic surgery with fascia and Vicryl mesh. From the above we conclude that Vicryl mesh is not suitable for splintage in myringoplastic surgery.

Animals↗

How useful is tricalcium phosphate ceramic in middle ear surgery?

In our experiments on the hypotympanum of the pig, resorbable porous tricalcium phosphate ceramic has proved to be serviceable for reducing radical mastoidectomy cavities and as a substitute for osseous walls. For our initial clinical trials with porous tricalcium phosphate ceramic in middle ear surgery, we had implants made especially for the purposes of replacing osseous walls and reducing radical mastoidectomy cavities. When implants have been used to replace osseous walls, insufficient ventilation of the tympanic cavity has frequently coincided with complications in the covering between implant and auditory canal. Follow-up operations have afforded opportunities for histologic examination of fifteen implants, which served as wall replacements for nine to thirty months. There were only the slightest traces of resorption and replacement by bone. In contrast with our findings on the replacement of walls with ceramic implants, postoperative observation for periods of up to four years has shown that granules of porous tricalcium phosphate ceramic are well suited to reducing radical mastoidectomy cavities.

Animals↗

Heart muscle necroses following normobaric hyperoxia: modification by beta-blocking agents and calcium antagonists.

Heart muscle necroses can be produced in rabbits by normobaric hyperoxia. The pathogenesis of these lesions is controversial. In our investigations we found that such necroses can be prevented by beta blockers, but not by a calcium antagonist. This can be explained by the different action of the two drugs on the coronary arteries. The result supports the view that heart muscle necroses after normobaric hyperoxia are a direct toxic effect of oxygen on the heart muscle fibers.

Adrenergic beta-Antagonists↗

[Frequency of kidney cyst wall cancer--results of 22,000 ultrasound studies].

In 22 198 sonographic examinations of the epigastric region, the authors identified 759 renal cysts (3.4%) and 165 renal tumours (0.74%). The percentage of incidence of the renal cysts is identical with that found in post-mortem examinations, whereas tumours were distinctly more frequent. Tumours of the cystic wall had been found in 0.5% of all sonographically diagnosed cysts and in 4% of renal cysts examined via fine-needle biopsy. Of the latter cysts (i.e. out of the 4% of cysts diagnosed by fine-needle biopsy), which were associated with tumours, two had been diagnosed as tumour suspects via sonography. Hence, the sonographic absence of abnormal findings in carcinoma of the renal cyst wall is rare. However, cysts diagnosed via sonography which cannot be subjected to fine-needle biopsy, should be rechecked and followed up at regular intervals. If all possible methods of diagnosis are utilised (I.V. urography, sonography, fine-needle biopsy guided by sonography, computed tomography, angiography), successful differential diagnosis of localised pathological conditions of the kidneys can be achieved in 97% of all cases. Patient risk and cost of diagnosis can be kept at a minimum by proceeding in steps as described in the article. Primary surgical exposure of the kidneys in case of a cystic renal process would now appear justified for therapeutic reasons only, not for the purpose of arriving at a diagnosis.

Adenocarcinoma↗

[Obliteration of the mastoid cavity with porous tricalcium phosphate ceramic. Results 12 and 18 months after ceramic implantation in the hypotympanon of the pig].

The paper reports on the obliteration of mastoid cavities with resorbable tricalcium phosphate ceramic. As a model, we chose the pneumatic air cell system of the pig's hypotympanon, which resembles the human mastoid. At the time of surgery, the specimens were 10-12 weeks old. In a first group the cells of the hypotympanon were totally removed and the operation cavity was obliterated with adjacent layers of porous tricalcium phosphate ceramic. In a second group of specimens the air cell system was partly removed, leaving the apical part of the hypotympanon intact; the operation cavity was obliterated again with porous tricalcium phosphate ceramic. After 12 and 18 months survival the hypotympanons were removed and prepared for histological investigations. Those ceramic plates, lying close to the bony shell were strongly resolved and replaced by new bone. Other ceramic plates, however, especially those in the center of the implant, showed few signs of resorption and bony remodelling. Inside the ceramic implant there was hardly connective tissue. The space between the still unsolved ceramic plates was filled up with new bony tissue. This bone was partly structured and adjoined directly to the ceramic. The ceramic was integrated into the new bony tissue without any sign of an inflammation.

Animals↗

The influence of fine surface structures on the osseo-integration of implants.

The availability of inert materials like dense, pure Al2O3-ceramic or titanium allows the study of purely biomechanical influences of surface modulations or lacune on the osseo-integration of implants at different locations of the skeleton. The discovery of the "load-line-shadow" phenomenon in lacune of dental implants and the observation of the same effect in the grooves of hip sockets (Lindenhof type) indicate the general validity of the rules controlling the remodelling ability of bony tissue. Their application to the problems concerned with load transmission via surfaces which are mainly loaded by shear can contribute to achieve a well defined anchorage of implants.

Aluminum Oxide↗

[Are porous tricalcium phosphate ceramics suited for the replacement of bony walls in ear surgery? An animal experiment study of the hypotympanum of the domestic swine].

The purpose of this study was to examine the possibility of a partially or totally posterior canal and lateral attic wall reconstruction with a more stable and therefore less porous tricalcium phosphate ceramic plate (S8). The hypotympanon of 4 pigs was drilled out, leaving the bony shell intact. In the middle part of this cavity a 2 mm thick S8-ceramic plate was placed horizontally. The hypotympanon of further 11 pigs was drilled out and obliterated with a more porous tricalcium phosphate ceramic (S5). Additionally, a single S8 ceramic plate served as a wall to the cavum tympani. 1 to 18 months after operation the pigs were sacrificed; sections of the hypotympanon were investigated with light microscopy. After few weeks, the S8-ceramic plate was covered by granulation tissue and epithelium on the tympanic side. After three months newly formed bony tissue could be observed between the peripheral parts of the S8-ceramic plate and the tympanic epithelium. After six months both sides of the S8-ceramic plate were completely covered by new bone; moreover this bone is covered by the mucosa on the tympanic side. At this time the S8-ceramic plate has a tight bony contact to the shell of the hypotympanon and bone growth can be observed in the macropores of this plate. The bony layer on the tympanic side of the S8-ceramic plate remained slim, there was no exophytic growth after 12 months. After 18 months the S8-ceramic plate shows distinct signs of resorption and bony replacement. However, in comparison to the S5-ceramic this occurs slower and later.

Animals↗

Experimental studies on microcirculation under normobaric hyperoxia using the microspheres method.

The perfusion of the heart, kidneys, adrenals, stomach, intestines, brain and musculature under normobaric hyperoxia was studied in anaesthetized mini pigs using radioactively labelled microspheres. After a 2-hour control period using room air, the influence of normobaric hyperoxia on the perfusion of the organs was measured at 2-hour intervals. A significant increase in the perfusion of tissue was found in the kidneys, adrenals, gastro-intestinal tract and brain after 4-6 hours of exposure. No change in perfusion could be demonstrated for the myocardium. Values for the skeletal musculature (diaphragm and musculus psoas) were widely scattered, but an increase could be suspected. The increase in tissue perfusion at constant blood pressure and pulse rate must be interpreted as an expression of vasodilation. These results are contrary to the majority of statements in the literature, which mainly report vasoconstriction under normobaric hyperoxia.

Adrenal Glands↗