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Biomedical subjects

C M Bahary

Publications and source records attributed to C M Bahary.

23 records · Page 2Linked to original sources
PubMed1977

Necrotizing fasciitis.

Two cases of necrotizing fasciitis, a disease poorly documented in the gynecologic literature because of its extreme rarity, are described. These are the only cases of this entity seen in our department during the last 24 years. Both patients underwent major surgical procedures for uterine stromal sarcoma and mixed mesodermal tumor. In both, the pathognomonic signs, undermining of the skin, and extensive necrosis of the subcutaneous tissue and the underlying fascia, were present. Later gangrene occurred, and both patients died. The literature is briefly reviewed, which emphasizes the importance of immediate surgery when the disease is recognized. The possibility is suggested that the development of such local processes in cases of mixed mesodermal tumor may be an immunologic reaction and the cultured organisms contaminants.

Aged↗
PubMedDate not supplied

Expression of estradiol and progesterone receptors by histologically normal endometria of women with postmenopausal bleeding.

Estradiol and progesterone receptor levels (RE2, RP) were measured in histologically normal endometria of women with postmenopausal bleeding (PMB) and the results were compared to those in histologically normal endometria of premenopausal and postmenopausal (PM) women and to those in pathological PM endometria. In histologically normal PMB endometria, RP levels were comparable to those in secretory premenopausal endometria and significantly higher than those in PM atrophic endometria. The RP levels in the former group correlated with the respective RE2 levels and the values of the ratio RP/RE2 occupied a mid-zone between those ratio values of normal premenopausal or pathological PM endometria on the one hand and normal PM endometria, on the other hand. The cytosolic/nuclear distribution of both receptor levels revealed that in both PMB and in pathological PM endometria, only a small fraction of the receptor was recovered in the nuclear extract. Expression of the RE2 and RP in the PMB and in the pathological PM endometria were associated with undetectable plasma E2 levels. These results indicate that histologically normal PMB endometria are biochemically active and suggest that endometrial growth and RE2, RP expression in PMB and pathological PM endometria are stimulated by a factor which acts distal to the RE2 acceptor.

Adult↗
PubMedDate not supplied

Distribution of total progesterone receptor levels in various segments and tissues of the normal human uterus: the effect of short-term estrogen administration.

Total progesterone receptor levels (TRP) were measured in various tissues and segments of normal human uteri in basal conditions (late proliferative phase, control group, n = 6) and after short term estrogen administration (test group, n = 8). Similar trends of distribution were observed in both groups in basal endometrial TRP levels along the longitudinal axis, i.e. the highest levels were found at the height of the body and the lowest at the height of the internal os. Differences were found in the trends of distribution of the TRP levels between the two groups along the transverse axis of the uterus at the height of the fundus. In the control group TRP levels in the functional endometrium were higher than those in the basal endometrium and myometrium. In the test group, however, the trend was reversed. Since the RP is estradiol induced and dependent, these results indicate the possibility of a selective estrogen effect on various segments or tissues in the human uterus.

Adult↗