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Biomedical subjects

C M Booth

Publications and source records attributed to C M Booth.

36 records · Page 2Linked to original sources
PubMed1983

The structure of the bladder neck in male bladder neck obstruction.

A light microscope and neurohistochemical study is presented of full thickness biopsies from the bladder neck of 10 middle-aged males with urodynamically proven bladder neck obstruction. Apart from varying degrees of collagen deposition in seven cases, no abnormality was present in the detrusor and pre-prostatic components of the bladder neck muscles or in the distribution of cholinergic nerve fibres. The normal noradrenergic innervation to the pre-prostatic sphincter was absent in all specimens; this may be age-related.

Adult↗
PubMed1983

Histological and urodynamic study of the bladder in enuretic children.

In a study of the bladders of 12 enuretic children by cystoscopy, light microscopy and urodynamics, cystoscopic trabeculation was found in 10 cases. Histologically, the trabeculation resembled adult trabeculation of obstructive aetiology, collagen infiltration being the characteristic hallmark. Using urodynamic measurements, the bladders behaved like those of adult enuretics; 10 out of 12 were unstable and voiding occurred at relatively high pressures. There was no correlation between symptoms and either cystoscopic or histological trabeculation.

Adolescent↗
PubMed1982

Electrical anal stimulation and the prediction of bladder stability after surgical relief of male outflow obstruction.

In an attempt to predict which unstable bladders in males with outflow obstruction would convert to stability following surgery, we performed functional electrical stimulation (FES) of the anus during pre-operative rapid fill cystometry in 13 patients with benign prostatic hypertrophy (BPH) and 5 patients with bladder neck obstruction (BNO), all of whom had associated instability. Instability was suppressed in only 2 patients with BPH. Although suppression was achieved in 4 patients with BNO, no correlation was found with either post-operative stability or symptomatology in this group or the patients with BPH and we conclude that FES has no predictive value in this context.

Adult↗
PubMed1981

A long-term study of the persistence of the urodynamic characteristics of the unstable bladder.

Sixty-four patients with normal bladder function, stress incontinence, idiopathic instability or instability associated with enuresis underwent pressure/flow videocystography. This was repeated from one month to 8 years later (average 19.4 months). Filling cystometry remained qualitatively unchanged in 95% of cases overall, whilst the actual pressure recordings during cystometry in the 37 patients with instability remained identical or very similar in 73%. The results demonstrated the accuracy of cystometry and the consistency of bladder dynamics over the longest period so far reported in these apparently non-progressive disorders.

Adolescent↗
PubMed1981

Intravenous urography in the follow-up of carcinoma of the bladder.

A urographic survey of 250 patients being followed for bladder cancer revealed 3 unsuspected ureteric tumours and 18 cases of ureteric obstruction. The tumours occurred in patients always affected by bladder recurrence and the obstructions were largely due to treatment of paraureteric bladder tumours by cystodiathermy or radiotherapy. Regular follow-up intravenous urography is therefore unnecessary except in patients with frequent recurrences, but we advocate radionuclide renography as an essential, inexpensive screening test to rule out ureteric obstruction following the treatment of paraureteric tumours.

Adult↗
PubMed1981

Unheralded urinary tract infection in the male. A clinical and urodynamic assessment.

Fifty adult males presenting with unheralded single or recurrent urinary tract infections, but without prior urinary symptoms or disorders, were investigated by appropriate urodynamic techniques. Pressure/flow videocystography revealed significant underlying lower urinary tract abnormalities in 40 cases (80%) compared with only 11 (22%) whose abnormalities were also demonstrated by standard intravenous urography or endoscopy. We suggest that videocystography is the most efficient diagnostic procedure for these cases in a specialist unit but recommended the intravenous urodynamogram as a simpler screening test for general use.

Adolescent↗
PubMed1980

Urothelial carcinoma of the kidney and ureter.

Two hundred and three patients with upper tract urothelial tumours were reviewed. Eighty had pelvicaliceal tumours, 90 ureteric tumours, and 33 multifocal tumours of both pelvis and ureter. Two hundred patients had transitional cell carcinomas and 3 had squamous cell carcinomas. The overall corrected 5-year and 10-year survival rates were 59.7% and 41.1% respectively. Widespread multifocal occurrence poor differentiation, penetration of the muscle coat and conservative resection of tumours predisposed to a poorer prognosis.

Adult↗
PubMed1980

A prospective trial of bladder training as treatment for detrusor instability.

Bladder training, without the additional use of drugs, has been used as treatment for detrusor instability. In a 3-month prospective trial, with historical controls, nearly half of the treated patients were either cured or improved. Bladder training is, therefore, a successful non-invasive technique devoid of complications and is recommended for the treatment of mild detrusor instability.

Adolescent↗
PubMed1979

Chronic dislocation of the sternoclavicular joint: an operative repair.

Chronic spontaneous dislocation of the sternoclavicular joint occurs more frequently in athletes than nonathletes, causing weakness and sometimes pain during prolonged stress upon the arm. Five such joints were successfully treated in 4 patients by means of a dynamic method of repair--tenodesis of the sternal head of the sternomastoid muscle. The sternal origin of the sternomastoid muscle in continuity with its muscle belly and strip of sternal periosteum is looped under the first rib, back through a drill hole in the clavicle and sutured to itself to replace the damaged costoclavicular ligament. Dislocations of the joint should not be repaired for purely cosmetic reasons as the risk of keloid scar formation in this region is notoriously high. All the patients who were young and athletically inclined, recovered fully within 4 months of the operation and returned to their sporting activities. Follow-up has ranged from 12 to 38 months. There have been no late complications or failures of the technique.

Adolescent↗
PubMed1977

High pressure paint gun injuries.

Despite their use for the past 20 years the dangers of injuries from high pressure paint guns are not widely known. Two cases treated incorrectly through ignorance in our casualty department resulted in amputation of digits. Paint solvents are far moe damaging than paint of grease injection. All cases should be treated urgently by an experienced surgeon as fairly extensive surgery may be needed.

Accidents, Occupational↗
PubMedDate not supplied

Immunoelectrophoretic evidence that the human syncytiotrophoblast transferrin receptor is identical to a major plasma membrane antigen present throughout pregnancy.

Crossed immunoelectrophoresis of solubilized syncytiotrophoblast microvillar proteins has been performed through intermediate gels, containing a monospecific antiserum to transferrin, into gels containing an antiserum raised to purified microvilli from term placentae. This technique resolved the microvillar transferrin-receptor complex into its component proteins. Crossed hydrophobic interaction immunoelectrophoresis confirmed that the transferrin receptor is an amphiphilic integral membrane protein. It is also a major antigen of the microvillar membrane and is present throughout pregnancy.

Antigens↗
PubMedDate not supplied

Postnatal development of the adult pattern of motor axon distribution in rat muscle.

Establishment of the adult pattern of connections between motoneurones and their muscles is known to be achieved in stages. There is an initial guidance mechanism which in higher vertebrates directs the axons with considerable accuracy to their appropriate muscles. This is followed by a stage when a large proportion of neurones die. Then, after birth, the final modifications are brought about by elimination of redundant motoneuronal branches. We present here evidence that branch elimination does not occur at random from within a motoneurone's initial intramuscular distribution, but in such a way as to sharpen the segmento-topic relationship within a muscle that motoneuronal death had earlier provided.

Aging↗