Serum protein profiles in coccidioidomycosis.
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Biomedical subjects
Publications and source records attributed to C M CARPENTER.
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1. A significant cytotoxic effect of trypsinized, sensitized cell cultures was observed when re-exposed to Brucella antigens in vitro. 2. The cytometric assay of the toxic effects of Brucella antigens using trypsinized cells from sensitized animals provides an objective measure of induced cellular hypersensitivity.
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Recent years have witnessed a slight decrease in the sensitivity of certain gonococcal strains to penicillin. A survey of the pertinent literature, however, indicates that most reports of gonococcal infections which are unresponsive to "adequate" doses of penicillin are not sufficiently substantiated by valid clinical and laboratory studies to demonstrate beyond doubt the existence of truly penicillin-resistant strains. Nevertheless, the possibility of such resistance is real and important. Investigations to determine with certainty whether the gonococcus is acquiring a significant degree of resistance should include measurement of penicillin blood levels, prevention of re-exposure, confirmation of diagnosis by cultures, elimination of possible host factors when apparently recalcitrant cases are encountered, and careful laboratory confirmation of the in vitro penicillin-resistance of the strains involved.
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