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Biomedical subjects

C M Drew

Publications and source records attributed to C M Drew.

9 recordsLinked to original sources
PubMed1997

REPCAT: desktop expert system for interpreting and validating laboratory data for pheochromocytoma diagnosis with the database application Omnis 7.

To aid in the validation and interpretive reporting of results from multianalyte diagnostic testing for pheochromocytoma (PHEO), we have developed a desktop personal computer-based laboratory expert system (REPCAT). REPCAT utilizes a commercial database application to run procedures that assess analytical and clinical data relating to patient urine or plasma samples. REPCAT was used to evaluate the raw data from >4000 24-h urine samples submitted to our laboratory for testing for the presence of PHEO. REPCAT performed equivalently to an expert pathologist in assessing the presence and class of PHEO (epinephrine, norepinephrine, or mixed secretor). No false negatives were generated and it assigned a correct interpretation (on the basis of subsequent clinical and biochemical investigation) for each of the primary diagnostic samples from these patients.

Adrenal Gland Neoplasms↗
PubMed1975

Inhibitor effects during the cell cycle in Chlamydomonas reinhardtii. Determination of transition points in asynchronous cultures.

A wide variety of inhibitors (drugs, antibiotics, and antimetabolites) will block cell division within an ongoing cell cycle in autotrophic cultures of Chlamydomonas reinhardtii. To determine when during the cell cycle a given inhibitor is effective in preventing cell division, a technique is described which does not rely on the use of synchronous cultures. The technique permits the measurement of transition points, the cell cycle stage at which the subsequent cell division becomes insensitive to the effects of an inhibitor. A map of transition points in the cell cycle reveals that they are grouped into two broad periods, the second and fourth quarters. In general, inhibitors which block organellar DNA, RNA, and protein synthesis have second-quarter transition points, while those which inhibit nuclear cytoplasmic macromolecular synthesis have fourth-quarter transition points. The specific grouping of these transition points into two periods suggests that the synthesis of organellar components is completed midway through the cell cycle and that the synthesis of nonorganellar components required for cell division is not completed until late in the cell cycle.

Acridines↗