International studies in chronic respiratory disease.
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Biomedical subjects
Publications and source records attributed to C M Fletcher.
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The change in specific airway conductance produced by smoking a cigarette under standard conditions was measured in 91 heavy smokers. Subsequently 19 of the most reactive subjects smoked two cigarettes with different filters and another containing cigar tobacco. The results indicated that reactivity to cigarette smoke was reduced significantly by increasing the retention efficiency of the filter and that reactivity to inhaled cigar-tobacco smoke was no less than that to cigarette smoke.
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Measurements of peak expiratory flow can be made by outpatients on themselves. This technique, which may be carried out at home, has proved to be valuable in assessing the effect of steroids and other bronchodilator drugs in relieving airway obstruction.
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