Biomedical subjects
Publications and source records attributed to C M Garrido.
Ten cases of melanoma and 5 ocular nevus were studied with the peroxidase-antiperoxidase method with S100 protein. All the cases showed positivity for this protein, this is why we can advise its use in the diagnosis of these entities.
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11 orbital embryonic rhabdomyosarcomas were studied immunohistochemically from patients under 4 years of age. One out of these cases, undifferentiated, showed to be myoglobin negative, and desmin positive. We point out the importance of this fact in immunohistochemical determination of the specificity of this entity.
15 cases of ocular retinoblastomas, 10 differentiated and 5 undifferentiated, were studied with the following antibodies: neuron-specific enolase, S100, and tubulin. All cases turned out negative with S100 and tubulin labeling. The well-differentiated retinoblastomas were NSE-positive, and only 2 of the 5 undifferentiated retinoblastomas were positive for the same antibody. The observed results let us conclude that S100 and tubulin are not useful in diagnosing this entity and that enolase, although it showed its value in the differentiated retinoblastomas, did not have the same effect in the undifferentiated retinoblastomas, as it was negative in 3 out of 5 cases.
The technique and results of 30 iridocyclectomies performed by the senior author are reviewed. Although the total number of cases is small for statistical purposes, its main value is that all the operations were performed by one surgeon, which means a uniform criteria for the indications, surgical technique, management of complications, immediate and postoperative decisions, follow-up control, and direct discussion of the histopathology with the pathologist. Three techniques were used: (1) routine excision only of uveal tissue in 15 cases, (2) cyclectomy, ie, plus excision of deep scleral wall in four cases, and (3) block excisions of cornea, sclera, affected iris, and ciliary body followed by a reconstructive penetrating graft in 11 cases. Twenty-one cases were melanocytoma; one, metastatic tumor; one, nevus; two, cysts; and three, foreign body granulomas. Prognostic features such as cell type, largest diameter above 10 mm, tumor thickness, tumor at edge, iris or ciliary body origin, location, and preoperative glaucoma are discussed, and some practical conclusions are advanced. The follow-up control for 21 melanoma cases in the series is five to ten years or more in 11 cases and up to four years in ten cases. The visual results are also analyzed.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.