Biomedical subjects

C M Goldgar

Publications and source records attributed to C M Goldgar.

2 recordsLinked to original sources

PubMed1986

Lack of correlation of small bowel biopsy and clinical course of patients with intractable diarrhea of infancy.

To assess the value of small bowel biopsy in determining the prognosis of intractable diarrhea of infancy, small bowel biopsy specimens of 19 infants with this disorder were examined blindly, and a score reflective of the severity of injury for each biopsy specimen was derived. Biopsy scores were correlated with the duration of nutrition support required in the treatment of each patient. No correlation could be found between the severity of the small bowel mucosal injury on biopsy and the clinical course of the patient. Small bowel biopsies are not likely to be of assistance in determining the prognosis of this disorder and should not be used to determine therapy or to advise parents concerning the likely duration of intractable diarrhea of infancy.

Biopsy↗

PubMedDate not supplied

Intestinal abnormalities with central nervous system malignancy.

Two anorectic, emaciated infants with central nervous system (CNS) neoplasms are reported. Diagnosis in each case was delayed, because computed tomography of the head was initially falsely negative, and because primary gastroenterologic illness was suggested by the presence of mild inflammation and villous atrophy of the small intestine. This experience indicates that the diagnosis of CNS neoplasm must be aggressively pursued in cachectic infants who refuse to eat, regardless of the results of the initial radiologic studies. Mild histologic abnormalities of the small intestine that may be present in infants with brain tumors probably represent a nonspecific response to starvation and, if unassociated with malabsorption, should not be considered the cause of illness.

Astrocytoma↗