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Biomedical subjects

C M Ideström

Publications and source records attributed to C M Ideström.

At least 19 recordsLinked to original sources
PubMed1983

Alcohol consumption, neuropsychological status and computer-tomographic findings in a random sample of men and women from the general population.

There was no correlation between reported amount of alcohol consumed on each drinking occasion per se and neuropsychological and neuroradiological signs of cerebral disorder in age-stratified random sample of 200 men and 200 women taken from the general population. Furthermore, moderate to heavy social drinking as assessed by an index based on amount of alcohol consumed on each drinking occasion and the responses to some other alcohol-habit questions was not associated with signs of cerebral disorder. Alcohol dependence, however, was associated with signs often diagnosed in alcoholic patients but milder in degree. There were indications of important differences between men and women with regard to the relationship between advanced alcohol-habits and cerebral disorder.

Adult↗
PubMed1980

Computed-tomography of the brain and neuropsychological assessement of alcoholic patients.

The purpose of the project is to assess the state of the brain of alcoholic patients by means of computerized tomography and by neuropsychological performance and to correlate the findings with the clinical course of alcohol dependence. The investigated group is a consecutive series of 106 patients admitted for treatment of alcoholism and participating in a prospective program of mapping medical, social and psychological characteristics. Cortical changes were diagnosed in 59.6 % of the investigated patients, enlarged lateral ventricles in 33.3 % and an enlarged 3rd ventricle in 48.3 %. With regard to neuropsychological functioning 54.2 % of the sample scored in the mildly to severely impaired region of the Halstead Impairment Index and 63.5 % were considered to show signs of an intellectual impairment in the psychologist's overall assessment of test results. Cortical changes and ventricular enlargement seemed to follow different courses in the investigated group since they were uncorrelated in the sub-group of older patients with long duration of heavy drinking. The correlations between neuropsychological functioning and morphological changes were generally low. However, the results suggest that learning and memory deficits indicate subcortical changes in the brains of alcoholic patients while a high score on the Halstead Impairment Index indicated cortical changes.

Adult↗
PubMed1980

Alcohol intoxication and hangover: modification of hangover by chlormethiazole.

Alcohol intoxication and hangover were studied in 12 healthy male subjects who participated in three 18-h experimental sessions; two sessions in which they consumed 1.43 g alcohol/kg body weight as mixed beverages together with food, and one control session when mineral water was substituted for the alcoholic beverages. In one of the alcohol sessions they received chlormethiazole, 1 g at bedtime and 0.5 g early the following morning, in the other, they were given placebo tablets. The following variables were studied: blood-alcohol concentration; blood pressure; heart rate; blood lactate; blood pyruvate; urinary catecholamines (only during hangover); psychomotor and cognitive capacities; as well as subjective reactions. During intoxication, heart rate and lactate-pyruvate ratio were significantly increased and performance efficiency was significantly deteriorated in comparison with the control condition. During hangover, heart rate, blood pressure, and lactate-pyruvate ratio were significantly elevated, and cognitive performance was still affected, in some tests to a significant degree. During this stage there was a great variation between subjects as regards subjective hangover. Chlormethiazole was found to lower blood pressure and adrenaline output and, furthermore, to relieve unpleasant physical symptoms, but did not affect fatigue and drowsiness. The cognitive test results were only slightly influenced by this agent, while psychomotor performance was significantly impaired. Subjects with severe subjective hangover seemed to benefit more from the chlormethiazole treatment than subjects with a mild hangover.

Adult↗
PubMed1979

Female alcoholics. V. Morbidity.

Data from the public health insurance societies regarding 66 female alcoholics, hospitalized for the first time for alcoholism at the Department of Alcohol Diseases, Karolinska Hospital, Stockholm, were studied, and the developmental pattern of morbidity was compared with that of 68 male alcoholics fulfilling the same criteria. The observation period was 15 years. The progress of the alcoholism was not reflected in data from the social insurance societies up to the time of the first clinical treatment. However, the morbidity increased in both sexes after the treatment period, with higher disability, severity, and frequency rates, a large number of persons with disability pensions and increasing social stigmatization. The proportion of women granted disability pensions increased to significantly higher values than that of men, and that of women in the general population. The women had significantly fewer registrations in social registers than the men during the whole period. Women and older patients had higher disability rates, more sick-days due to "mental diseases" and a higher severity rate before admission. All differences were equalized in the last part of the study.

Absenteeism↗