Biomedical subjects

C M Jan

Publications and source records attributed to C M Jan.

At least 37 records · Page 2Linked to original sources

PubMed1992

[Flow cytometric analysis of DNA in esophageal cancer].

Malignancy is the first of the ten leading causes of death in Taiwan area, however, since 1978, esophageal cancer is on the first ten causes of malignancy. Esophageal cancer is an aggressive neoplasm with a generally poor prognosis. This is usually related to the advanced stages of the neoplasm at presentation and at diagnosis. In this study, the DNA content in tumor was analyzed by flow cytometry, and compared it with clinical- pathological data, especially the survival time. All thirty seven cases (36 male, 1 female, mean age: 56.5 +/- 10.3 y/o) received operation at Kaohsiung Medical College Hospital in the past 11 years and 29 cases (27 male, 2 female, mean age: 62.2 +/- 9.6 y/o) proved to be esophageal cancer by endoscopic biopsy were assayed in this study. The formalin fixed-paraffin embedded block is used to analyze DNA content by flow cytometry. After comparing these results with clinical-pathological data, there were no significant difference in sex, age, duration, tumor location and length. However, there is a significant correlation between ploidy and tumor cell differentiation, that is, most of the diploid cells were well differentiated while most of the aneuploid cells were poorly differentiated. The median survival time of diploid cases was 325 days which was longer than the 277 days in aneuploid group, but there was no significant difference between these two groups. The same result was noticed in DNA index. Multiple variables analysis of prognostic factors disclosed that there were significant difference in correation with age tumor location tumor length, and whether there was combined radiotherapy and operation. But there were no significant relationship between survival and DNA ploidy DNA index distant metastasis surrounding tissue invasion sex duration and tumor cell differentiation. These data suggest that DNA folw cytometry analysis alone, may not provide a sueful biologic basis for the variable prognosis seen with esophageal tumors.

Aged↗

PubMed1992

Comparison of omeprazole and nizatidine in the treatment of duodenal ulcers.

This study compares the efficacy and side effects of omeprazole and regular- and double-dose nizatidine in the treatment of duodenal ulcers. Duodenal ulcer healing rates in these three groups (omeprazole, 20 mg qd; nizatidine, 300 mg hs and 600 mg hs) were 81.8%, 19% and 30%, respectively, after two weeks of therapy; and 90.5%, 70% and 84.2%, respectively, after four weeks of treatment. Omeprazole had a significantly better healing rate than nizatidine, 300 mg or 600 mg, after two weeks of treatment (p < 0.01), but not after four weeks of treatment. Omeprazole relieved the ulcer pain sooner than nizatidine (p < 0.05). Smoking decreased the duodenal ulcer healing rate in the omeprazole group, but not in the nizatidine groups. Clinical features, such as sex, age, alcohol consumption, ulcer size, past history of upper gastrointestinal bleeding and duration of peptic ulcer history, did not collate with the healing rate. Patients with double-dose nizatidine did not show any benefits over those with a regular dose in this study. Adverse effects were minor, and there were no significant changes in biochemistry after therapy in these three groups of patients.

Adult↗

PubMed1990

Gastrointestinal tract involvement in hepatocellular carcinoma: clinical, radiological and endoscopic studies.

Gastrointestinal tract involvement with hepatocellular carcinoma was observed in 8 out of 396 patients (2%) during the course of the disease. Histological involvement was confirmed in 6 cases. All 8 patients were men. The most common clinical presentation was frank gastrointestinal bleeding, which became evident in all cases. Esophageal varices were not seen in any patient. The sites of involvement were the stomach (3), duodenum (4), and jejunum (1). The median time between the diagnosis of primary tumors and gastrointestinal tract involvement was 4.5 months (range: 0 to 12 months). Hematogenous spread was presumed to have occurred in two patients with diffuse-type hepatocellular carcinoma, one of whom had main portal vein thrombosis. Direct invasion by contiguous neoplasm was the major mode of gastrointestinal tract involvement. This complication is more likely to develop in patients with large, subcapsular, massive type hepatocellular carcinoma treated by transcatheter arterial embolization and/or intra-arterial chemotherapy. The median survival after the diagnosis of gastrointestinal involvement was 1 month (2 weeks-4 months).

Adult↗

PubMed1990

Evaluation of urease test, gram stain, culture, and histology in the detection of Campylobacter pylori.

To evaluate the commonly available tests for detection of Campylobacter pylori infection in the human stomach, we prospectively performed endoscopy and biopsy from the antrum of the stomach in 121 consecutive patients. Four tests, including the urease test, Gram stain, culture, and the hematoxylin and eosin (H & E) stain were used to detect the presence of C. pylori. A C. pylori positive was defined by a positive culture or positive results in two of the other three tests. The sensitivity of the urease test, Gram stain, culture, and H & E stain was 95%, 95%, 71%, and 97%, respectively, and the specificity of those tests was 96%, 100%, 100%, and 73%, respectively. For diagnosis, theoretically, all four tests should be performed from the biopsy specimens. In our experience, the culture was less sensitive, and the H & E stain was less specific, while the urease test and Gram stain were more rapid and had high sensitivity and specificity in the detection of C. pylori infection.

Adolescent↗

PubMed1990

Central nervous system infection after endoscopic injection sclerotherapy.

Central nervous system (CNS) infection is a rare complication of endoscopic injection sclerotherapy (EIS) for esophageal varices. We report two patients, one of whom developed a solitary brain abscess, and the other, acute meningitis, after EIS. They presented with high fever initially, and then with changes in mental status. In the case of the solitary brain abscess, the CSF revealed evidence of infection, and CT scan disclosed a brain abscess in the left temporo-parieto-occipital region. This patient received EIS six times and developed the CNS complication 4 wk after the last EIS. There was no growth in either the CSF or the abscess cultures in this case. The other patient with acute meningitis, which developed on the second day after the second session of EIS, had a positive CSF culture of Klebsiella pneumoniae. Both of these patients died despite antibiotic treatment, and craniotomy with drainage in the patient with a brain abscess.

Acute Disease↗

PubMed1989

Incidence of massive rebleeding from nonbleeding visible vessels in benign gastroduodenal lesions and prospective study in assessing the efficacy of endoscopic hemostasis with local ethanol injection for prevention of rebleeding.

Twenty-seven patients presenting with massive upper gastrointestinal bleeding in whom endoscopy revealed nonbleeding visible vessels in benign gastroduodenal lesions were prospectively and nonrandomly allocated to receive endoscopic injection therapy with pure ethanol or conservative treatment. Those who received conservative therapy were used as a control group. The purpose of this study is to evaluate the incidence of massive rebleeding from the nonbleeding visible vessel which was defined by a more rigid criteria and to evaluate the efficacy of endoscopic pure ethanol local injection to prevent rebleeding. Nine out of the 10 (90%) controls had recurrent major bleeding, in contrast to the 2/17 (12%) of those who received hemostatic endoscopy (p less than 0.0002). Pure ethanol local injections also minimized further transfusion requirements (p less than 0.03). The complications of hemostatic endoscopy in this study are negligible. It is concluded that 1) by restrictive definition nonbleeding visible vessels in benign gastroduodenal lesions carry a high potential of recurrent massive bleeding; 2) rebleeding can be safely and effectively prevented by pure ethanol local injection.

Adolescent↗

PubMed1989

[Gastroduodenoscopic findings and clinical analysis in patients with dengue fever].

The following is a report of the recent Dengue Fever epidemic in Southern Taiwan. From Sept, 1988 to Nov, 1988, 76 patients were clinically diagnosed with fever, leukopenia, thrombocytopenia and other classical signs and symptoms of Dengue Fever. Among them 26 cases were proven by serology. Analysis and discussion were emphasized on the gastroduodenoscopic findings, histopathologic findings and relationship between upper gastrointestinal tract bleeding and thrombocytes, oral medication and clinical symptoms. 655 patients having undergone endoscopy within the same period were used as a control group. It was concluded that: 1) 58.5% of the Dengue Fever Group disclosed hemorrhagic gastritis in their endoscopic findings and in the control group only 8.9% was noted. 2) Patients with thrombocytes less than 50000/mmc suffered from UGI bleeding at a detection rate of around 48.6%. On the other hand, the detection rate was around 29.7% in those patients with thrombocytes over 50000/mmc. Thus a significant difference was shown (p less than 0.025). 3) The thrombocyte count decreased significantly in patients who had had oral medication before endoscopy compared to those without oral medication. The detection rate of UGI bleeding was 40.6% and 26% respectively (p less than 0.025). 4) Most upper G-I bleeding cases occurred after the 4th day of onset, especially in the group without oral medication. 5) There was no significant relationship between UGI bleeding and symptoms of epigastralgia or cutaneous eruption. 6) In cases of presenting hemorrhagic gastritis and superficial plus hemorrhagic gastritis by endoscopy, the detection rate of UGI bleeding seemed higher but there was no statistical difference.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗

PubMed1988