Biomedical subjects

C M Johnsen

Publications and source records attributed to C M Johnsen.

4 recordsLinked to original sources

PubMed1988

Cholecystectomy and adenomatous polyps of the colon in women.

The relationship between prior cholecystectomy and colon cancer in women has been a subject of recent research interest. No study has yet reported on cholecystectomy and adenomatous polyps, a precursor lesion for most colon cancers. This pilot case-control study interviewed 245 women who had undergone colonoscopy between 1983 and 1985 at Columbia-Presbyterian Medical Center with a structured telephone-administered questionnaire. Fifty-six were colon cancer cases, 105 were adenomatous polyp (AP) cases, and 84 were controls (without colonic neoplasia). Adjusted for age and educational attainment, the odds ratio for prior cholecystectomy among colon cancer cases compared to controls was 1.79 (95% confidence limits, 0.59 to 5.44) and 2.26 for right-sided colon cancer cases (95% confidence limits, 0.61 to 8.42). Despite a lack of statistical power, these estimates are consistent with earlier reports. The odds ratio for adenomatous polyp cases was 1.02 (95% confidence limits, 0.40 to 2.64), suggesting no association between prior cholecystectomy and adenomatous polyps. These preliminary findings are currently being explored in a large-scale case-control study.

Aged↗

PubMed1988

Vitamin supplements among women with adenomatous polyps and cancer of the colon. Preliminary findings.

Chemoprevention of various epithelial cancers with vitamins or minerals has been the subject of multiple intervention trials to assess the impact of supplementation. These include several trials in patients with adenomatous polyps of the colon, a precursor lesion for colon cancer. The authors interviewed 255 women who underwent colonoscopy at Columbia Presbyterian Medical Center between 1983 and 1985 with a telephone-administered structured questionnaire. Eleven interviews were excluded for various reasons. Overall, 57.7 percent of the 244 interviewees used vitamin pills on a regular basis (at least once a week for a year); 6.6 percent of the interviewees used vitamin A, 20.7 percent used vitamin C, and 16.2 percent used vitamin E. There were no statistically significant differences in vitamin usage among women with adenomatous polyps of the colon (105 cases), women with colon cancer (56 cases), and women without colonic neoplasia (83 cases). Despite widespread use of supplementary vitamins, this study failed to demonstrate major benefits in preventing colon polyps or cancer.

Adult↗

PubMed1986

Serum cholesterol levels in adenomatous polyps and cancer of the colon. A case-control study.

A series of recent studies has shown an association between low serum cholesterol level and cancer, particularly of the large bowel. To explore this issue, serum cholesterol measurements were collected from 244 patients with adenomatous polyps of the colon, 182 patients with Dukes' A or B colon cancer, and 688 hospital controls who were diagnosed between 1979 and 1981 at a New York City hospital. The mean serum cholesterol levels were lower for patients with cancer (207.2 mg/dL) than for controls (219.5 mg/dL), with patients with Dukes' B cancer accounting for most of the difference. Patients with adenomatous polyps (219.8 mg/dL) were similar to controls. After adjustments for nutritional status using the serum albumin level, there were no statistically significant differences among any of the groups. We conclude that the low serum cholesterol level previously associated with malignancies, and colon cancer in particular, is a consequence rather than a cause of the cancer.

Aged↗

PubMed1985

Recurrence rates for colorectal polyps.

Of 276 patients who underwent an initial colonoscopic polypectomy for adenomatous polyps over a 45-month period, 118 subsequently had one or more repeat screening colonoscopies. The mean follow-up time was 26 months with an overall polyp recurrence rate of 30%. Analysis of these data retrospectively suggests that the bulk of the recurrences occurred within the first year. Increasing age was found to be a significant risk factor for polyp recurrence. Asymptomatic recurrence of adenomatous polyps detectable by colonoscopy is a common occurrence in postpolypectomy patients. Prospective studies utilizing colonoscopy as a screening tool are needed to establish a rational screening policy for this high-risk group.

Colonic Diseases↗