PubMed Health⌕ Search

Biomedical subjects

C M Jongerius

Publications and source records attributed to C M Jongerius.

5 recordsLinked to original sources
PubMed1977

Intrathoracic chemodectoma with multiple localisations.

In 1958 a mediastinal tumour was discovered in an asymptomatic woman with a history of vomiting and an oesophageal anomaly which had not been treated. A tumour of the anterosuperior mediastinum in relation to the aortic arch was extirpated and proved to be a chemodectoma or non-chromaffin paraganglioma. At subsequent follow-ups the mediastinum was never normal and the heart size progressively increased, the oesophageal anomaly remaining unchanged. A small opacity appeared in the left lung in 1974. An operation performed in 1975 revealed an osteochondroma in the lung, pericarditis, and an intrapericardial chemodectoma. The oesophagus was not explored. An intrathoracic chemodectoma is rare. The importance of angiography in its diagnosis is emphasised. Malignant degeneration is seldom observed. Therapy is surgical, the tumour being radioresistant. The possibility to be considered in our patient was either relapse of the tumour with degeneration or multiple localisations of the tumour.

Adult↗
PubMed1976

[Mediastinoscopy and bronchial carcinoma. Experience with 600 mediastinoscopies (author's transl)].

Of 600 mediastinoscopies carried out from 1966 to 1973, 479 were performed to assess the operability of a pulmonary carcinoma. Of these, (43%) were positive and (57%) negative. Of the 161 patients found positive during an initial period, 14 were considered candidates for operation. The tumour was irresectable in one patient, who died after 3.5 months; curative resection was possible in one and palliative resection in 12 patients. These 12 patients all died within a year. Of the 184 patients found negative during an initial period, 149 were treated by operation. The tumour proved irresectable in 5%, while curative resection was possible in 76% and palliative resection in 19%. Comparison with the period 1957-1963, when in the same hospital resection was performed after a negative Daniels biopsy, shows that the tumour was irresectable in 20%, while curative resection was possible in 35% and palliative resection in 45%. During a second period, patients with a positive mediastinoscopy were refused operation. Of 89 negative patients, 81 were treated by operation. No tumour was found to be irresectable; curative resection was possible in 78% and palliative resection in 22%. A survival study was made of 100 operated patients with a follow-up from a minimum of two years and four months to a maximum of four years and four months. The early mortality averaged 10%. The late mortality was 31% after curative lobectomy, 43% after curative pneumonectomy, and 100% after palliative resection. The survival was 49%

Bronchial Neoplasms↗
PubMed1975

[Pulmonary arterio-venous aneurysm and fistula (author's transl)].

Pulmonary arteriovenous aneurysms and fistulae (PAF) can appear in people with or without hereditary hemorrhagic telangiectases (HHT). There is a 3 to 6% chance to find PAF in members of a family with HHT and 17% chance to find PAF in a patient himself with HHT. The authors present the cases of 6 patients with PAF, 13 to 64 years old, all treated surgically. In this group there are as many males as females. Three patients with HHT had nose bleeding and hemangiomas in their family history. Three patients had dyspnoea on exertion and insufficient oxygen saturation. Two patients had neurological symptoms; four had extracardiac murmur. Location was 3 times in the inferior lobe, twice in the superior and once in the middle pulmonary lobe. Surgical treatment can be indicated for a clinical or roentgenological progression, for an important right-to-left shunt or for existing or anticipated complications such as hemorrhages, thrombosis with embolism and central nervous system disorders with cerebral abscess. For these reasons, surgical excision is also advisable in asymptomatic patients, where diffuse bilateral lesions are to be expected, that recur frequently. The authors performed one wedge resection, three segmental resections and two lobectomies.

Adolescent↗
PubMedDate not supplied

[Surgical treatment of pulmonary metastases (author's transl)].

From April 1954 till February 1976, pulmonary resections for metastases of primary extrapulmonary malignancies have been done on 35 patients, 21 men and 14 women with average age of 49 years 7 months. In about half of the cases the lung opacities were discovered occasionally. Three patients have undergone a second thoracotomy for a recurrent metastasis. Of the 48 resected metastatic lesions, 31 were located in the right and 17 in the left lung. Thirty were on resection unilateral and solitary. There was no operative mortality and the postoperative morbidity was neglectable. The cumulative 3- and 5-years survival percentages as obtained by the life-table method were 44.6 and 31.2. Better survival rates were found in the age group of 0-40 years and in the group of the sarcomas. Worse results were obtained when the primary tumor was invasive or associated with regional metastases. Resection of metastatic lung lesions larger than 5 cm diameter and especially the resection of multiple lesions gave poorer results. The time-interval between the primary operation and the pulmonary resection had no clear prognostic value. The factors determinating the palliative character of the pulmonary resection had a negative influence on the survival. None of the 9 patients with pulmonary metastasis and secondary intrathoracic lymphatic metastases did survive longer than 3 years. All these patients had a primary carcinoma. Out of this study no conclusions can be made as to the extension of the pulmonary resection.

Adolescent↗