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Biomedical subjects

C M Kumar

Publications and source records attributed to C M Kumar.

27 records · Page 2Linked to original sources
PubMed1985

Epidural test dose.

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Anesthesia, Epidural↗
PubMed1985

Excessive dose requirements of local anaesthetic for epidural analgesia. How far should an epidural catheter be inserted?

On two separate occasions, a 78-year-old obese man suffering from congestive cardiac failure and peripheral vascular disease, required epidural anaesthesia for surgery to his leg. The dosage requirement on the first occasion was large and much greater than on the second occasion. Reasons for the difference in dosage are discussed. We suggest an epidural catheter should be inserted 3 cm into the epidural space.

Aged↗
PubMed1980

A clarification.

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Camping↗
PubMed1979

Protease inhibitor variants in children and young adults with chronic asthma.

The results of systematic medical histories and pulmonary function tests on 26 children and young adults, 10 with Pi variant alpha1-antitrypsin phenotypes and 16 Pi normals, are reported. These subjects were selected from 57 consecutive patients who had chronic asthma. The incidence of Pi variants was 20.4% among 46 Caucasian subjects (ages seven to 21 years). The Pi variant patients required more bronchodilators and long-term corticosteroid therapy. Among the parents and siblings, 50% of those with abnormal Pi type had chronic obstructive lung disease. Grandparents of the Pi abnormal probands had greater incidence of chronic obstructive lung disease (P less than 0.05). Baseline specific airways conductance and maximal midexpiratory flow rates did not discriminat between the two groups. However, bronchodilator inhalation showed the Pi variant group to be significantly less responsive than the Pi normal group. Pi heterozygous state, particularly Pi MZ, should be considered when a young person with chronic asthma is unresponsive to adequate doses of bronchodilators and needs prolonged use of corticosteroids.

Adolescent↗
PubMed1978

Chronic rhinitis in the pre-school child.

The etiologic role of atopy in chronic rhinitis in 40 infants and pre-school children was investigated and the long-term effectiveness and safety of promethazine studied during six to 48 months. Twenty children were clearly atopic and 16 were not. Four had incomplete laboratory evidence of atopy. In addition to clinical histories and physical findings, the subjects were evaluated by skin tests for common allergens. RAST tests, total IgE levels and absolute eosinophil counts. Promethazine in doses of 3 to 12 mg/kg/day (mean 8 mg) was administered in divided doses, four times a day for perennial rhinitis and on "as required" basis for recurrent and seasonal rhinitis. Side effects included drowsiness and irritability, which led to discontinuance of promethazine in one subject. There was no laboratory evidence of hematologic, renal or hepatic abnormalities. Promethazine was found to be an effective agent for symptom-control of chronic rhinitis in the pre-school child.

Asthma↗
PubMed1975

Electroencephalography in naval divers.

EEG studies were conducted on 98 naval divers to ascertain the incidence of abnormal paroxysmal activity in them and to correlate it with their performance in diving. Nine of the 98 showed EEG abnormality in the form of a buildup of high-voltage, low-frequency activity after hyperventilation. None of them showed sporadic bursts of sharp waves from any region on intermittent photic stimulation. A 5-year follow-up did not show any association between the EEG response and the diver's professional capabilities. Nine divers were also examined after a 30-min simulated exposure at 2.5 ATA breathing air. This simulated dive had no effect on the existing EEG pattern. It has been concluded that a routine EEG examination is not useful in selection of divers.

Adult↗