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C M Lopes

Publications and source records attributed to C M Lopes.

8 recordsLinked to original sources
PubMed1994

Some ectoparasites of commensal rodents from Huambo, Angola.

Eight species of ectoparasites were collected from 166 commensal rodents, including Rattus rattus (L.), Rattus norvegicus (Berkenhout), and Mus musculus (L.), from January to December 1986, in Huambo, Angola. The oriental rat flea, Xenopsylla cheopis (Rothschild), was the predominant species with respect to mean intensity and prevalence. Other fleas collected were Ctenophthalmus (Ethioctenophthalmus) machadoi Ribeiro, Dinopsyllus (Dinopsyllus) smiti Ribeiro, and Echidnophaga gallinacea (Westwood). The mite Laelaps (Echinolaelaps) muricola Trägärdh, the louse Polyplax spinulosa (Burmeister), one species of Ixodes Latreille, and one species of Ornithonyssus Sambon were also recorded. The following represent new host records: C. machadoi from R. rattus and R. norvegicus, D. smiti from M. musculus, and L. muricola from R. rattus and M. musculus. For the first time, the monthly flea indices throughout the year are presented for Angola.

Acari↗
PubMed1992

[General qualifying exams: a report of experience at the doctorate level].

This is a report of experience obtained on the occasion of General Qualifying Exams taken by candidates to the Doctoral degree in the Graduate Program of the School of Nursing at São Paulo and Ribeirão Preto, of the University of São Paulo. Documents concerning legal rules were consulted, along with relevant literature that permitted us to obtain in-depth information about the research lines, methods and activities used by nursing researcher, as a way of facilitating the collection of information about authors. We trust that this experience will help clarify the subject for colleagues who intend to take these exams.

Abstracting and Indexing↗
PubMed1991

The effects of n-alkanols on the lipid/protein interface of Ca(2+)-ATPase of sarcoplasmic reticulum vesicles.

The effects of ethanol, n-butanol, n-hexanol and n-octanol on lipid-protein interactions in sarcoplasmic reticulum vesicles (SRV) are investigated using the C-14 nitroxide spin-labeled phosphatidylcholine. n-Alkanols, which activate the Ca(2+)-dependent ATPase of sarcoplasmic reticulum but decrease net Ca2+ uptake by the vesicles, are shown to affect the lipids interacting with the protein surface. Spectral analysis revealed that increasing concentrations of the alcohols progressively displace and mobilize lipids from the lipid/protein interface. For butanol, hexanol and octanol maximally activated SRV, 23 to 30% of the protein-interacting lipids are displaced. Thus, the displacement of more than 30% of the annular lipids by these alkanols cause inhibition of the enzyme. The motional properties of the labels that remain restricted by the protein surface are unaffected by the alcohols. The degree of mobilization attained by the labels displaced from the interface is much greater than that observed in alcohol-treated dispersions of extracted lipids. We propose that the alcohol molecules interfere with the protein-lipid interactions creating fluid clusters around the proteins. These fluidized regions would affect the enzyme conformation, perturbing its function. Fluidized annular lipids apparently increase the number of ion-conducting defects around the enzyme, increasing Ca2+ efflux, and thereby reducing net uptake.

Alcohols↗
PubMed1988

pH-dependent phase transition of chlorpromazine micellar solutions in the physiological range.

The effects of pH and drug concentration on aggregation properties of chlorpromazine-HCl (CPZ) are examined. The critical micelle concentration (cmc) changes from 0.2 mM at pH 7.3 to 2 mM at pH 5.6 as estimated from the stearic acid spin label solubility measurements. For concentrations above the cmc CPZ micelles undergo a concentration-, temperature- and pH-dependent transition leading to phase separation. This phase transition is followed by a sudden increase of light scattering. The phase diagram pH vs. concentration is obtained by observation of the cloud point for concentrations ranging from 0.01 to 10 mM. The intramicellar environment is probed at pH ranging from 5.5 to 8.0 using a stearic acid spin label. The intramicellar compactness increases smoothly with increasing pH suggesting the weakening of polar heads repulsion due to charge decrease. The reported results indicate that pH effects are relevant and should be properly taken into account in the performance and interpretation of experiments with CPZ.

Chlorpromazine↗