Biomedical subjects
Publications and source records attributed to C M MacLeod.
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Explore the source record for details and available documents.
Explore the source record for details and available documents.
Explore the source record for details and available documents.
Protein-bound homocyst(e)ine was measured in the plasma of 38 nonhomocystinuric patients with rheumatoid arthritis. Nineteen of them were treated orally with D-penicillamine 100-1,500 mg/d for a period of one month to 15 years. For these patients, the mean +/- standard deviation level of plasma protein-bound homocyst(e)ine was 1.95 +/- 1.07 nmol/mL. In contrast, the mean plasma level of protein-bound homocyst(e)ine was 4.72 +/- 1.11 nmol/mL in the 19 patients who had not been treated with oral D-penicillamine. There was a statistically significant difference (P less than .0001) in the plasma protein-bound homocyst(e)ine concentrations between patients with and without oral D-penicillamine therapy. Thus, it may be speculated that oral D-penicillamine may be beneficial in protecting patients from the development of thromboembolism and arteriosclerosis.
Three experiments investigated two timed implicit tests of memory--word reading and color naming. Using the study-test procedure, Experiments 1 and 2 showed that studied words caused reliable facilitation in word reading but no interference in color naming relative to unstudied words. Indeed, there was a small amount of facilitation in color naming as well. Experiment 3 further explored the color naming task by alternating shorter study and test intervals and adding controls trials consisting of letter strings. Although both studied and unstudied words showed interference relative to the control letter strings, the amounts of interference they showed did not differ. Overall, word reading consistently displayed facilitation whereas color naming never exhibited increased interference due to word priming. Priming appears to be process-specific: It is restricted to facilitating repetition of processing previously applied to a stimulus and does not extend to influencing performance on a different task involving the same studied materials.
We investigated the impact of attention during encoding on later retrieval. During study, participants read some words aloud (ignoring the print color) and named the print color of other words aloud (ignoring the word). Then one of two memory tests was administered. The explicit test--recognition--required conscious recollection of whether a word was studied. Previously read words were recognized more accurately than were previously color named words. This contrasted sharply with performance on the implicit test--repetition priming in lexical decision. Here, words that were color named during study showed priming equivalent to words that were read during study; both were responded to faster than unstudied words. Thus, an attentional manipulation during study had a strong effect on an explicit test of memory, but almost no effect on an implicit test. Focal attention during study is crucial for remembering consciously but not necessarily for remembering without awareness.
In a phase IV, open-label study, 25 patients with clinically stable chronic sinusitis and persistent maxillary sinus inflammation were treated for 14 days with clarithromycin 500 mg twice daily. Biopsy specimens of the maxillary sinus mucosa were obtained pretreatment and evaluated for macrophages (CD68), eosinophils (MBP), elastase, interleukin-6 (IL-6), IL-8, tumor necrosis factor-alpha (TNF-alpha), and activity of eosinophils (EG2), as well as edema score. Clinical signs and symptoms were assessed pretreatment, at the end of treatment, and 1 and 2 weeks later. Statistically significant reductions (P < or = .05) from pretreatment were observed for all markers of sinus mucosal inflammation, including CD68, EG2, elastase, IL-6, IL-8, TNF-alpha, and edema score, with a trend to decreased total eosinophil count. Improvement was observed for all clinical signs and symptoms of chronic sinusitis--sinus pain, sinus headache, nasal congestion, nasal discharge, and mucopurulent discharge--up to 14 days after the end of treatment. Cultures to evaluate persistent infection with Chlamydia pneumoniae showed negative results. Significant reductions in various markers of sinus mucosal inflammation support the role of clarithromycin in modulating immunologic responses. Improvement of clinical signs and symptoms in patients with chronic inflammatory sinusitis not meeting criteria for known or presumed bacterial infection was also noted up to 2 weeks after completion of a 14-day course of clarithromycin.
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