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C M Madsen

Publications and source records attributed to C M Madsen.

34 records · Page 2Linked to original sources
PubMed1977

13--25 Years follow-up after Swenson's operation for Hirschsprung's Disease.

77 patients with Hirschsprung's disease, operated according to the Swenson procedure in the period from 1949--1960 have been followed up in 1961 and 1975. 6 were dead, all from operative complications (a mortality of 8%). The results in the survivors were assessessed with regard to their bowel function and genito-urinary symptoms. The results in 1961 were 37 good (48%), 25 satisfactory (32%) and 9 poor (11%). In 1975, 8 patients were untraceable (10%), of the remainder 34 were good (44%), 22 satisfactory (29%) and 4 poor (5%), while 3 had been reoperated (4%). Two of the patients in the "poor" group had permanent enterostomy. The detailed assessment seems to indicate that diarrhoea and especially soiling in the first postoperative years are symptoms with a tendency to subside spontaneously. A residual constipation did subside in a few cases, but on a whole was much less likely to do so. In some instances, patients who for a long period had had normal stool passage again developed slight constipation, but only in one case a real recurrence with severe constipation was seen. tthere were no sexual complaints among the patients, and their fertility seemed normal. Only 5 patients had very moderate urinary symptoms, although a somewhat larger proportion of urinary anomalies might have been expected. (At the time of admission, a complete urological survey was not routine in these patients).

Adolescent↗
PubMed1976

Comparison of Dexon and Mersilene sutures in the closure of primary laparotomy incisions.

The study is a comparison of Dexon (polyglycolic acid) and Mersilene (polyester) sutures when employed for the primary closure of the peritoneum and aponeurotic layer in primary laparotomy incisions. The material comprises 308 closures of abdominal wounds with interrupted 2-0 sutures (United States Pharmacopeia) in the aponeurosis and continuous 2-0 suture of the peritoneum. One half of the wound was closed with Dexon and the other half with Mersilene, so that the patient acted as his own control. No significant difference was found between the two materials as evaluated from the occurrence of wound rupture within 10 days and incisional hernia within 90 days of the operation. Suture granulomas occurred in 9% of the half wounds sutured with Mersilene. The present clinical investigation demonstrates that Dexon sutures are as reliable as unabsorbable material. Dexon is superior to unabsorbable material as suture granulomas were not seen when Dexon was employed.

Adolescent↗
PubMed1975

Evaluation of peroperative cholangiography during cholecystectomy.

In a retrospective investigation comprising 219 choledochotomies, of which 57 were explorative (26%), and 162 were choledocholithotomies (74%), an attempt has been made to evaluate the indications for exploration of the common duct and the diagnostic reliability of post-explorative cholangiography. Retrospectively, we find that explorative choledochotomy was justified in 40 out of 57 cases, unless the risk of overlooking stones in the bile ducts was to be increased. In the remainder of the cases (17/57) it was a question of either misinterpretation or of non-evaluable cholangiograms. A diagnostic reliability of 93.6% was obtained at post-explorative cholangiography, making incidence of residual stones at postoperative cholangiography 6.4%. The errors were due to either technically poor cholangiograms (4/14) or misinterpretations (10/14). The conclusion is that peroperative cholangiography is a most important aid in diagnosing stones in the bile ducts before as well after choledochotomy, but that the results presumably to some extent can be improved by using radiological expertise.

Cholangiography↗
PubMedDate not supplied

Serum thyroglobulin in patients undergoing subtotal thyroidectomy for toxic and nontoxic goiter.

Twenty-five patients with nontoxic nodular goiters and six with toxic goiter were studied prior to subtotal thyroidectomy, with closely spaced blood sampling up to three weeks after surgery, and approximately one year after surgery. Serum thyroglobulin (Tg) was measured by a previously described radioimmunological method. The mean serum Tg was elevated in patients with nontoxic nodular and toxic goiters compared to sex and age matched control groups with pronounced increases during surgery. The disappearance curves of Tg in both groups had two exponentials, an initial steep slope with a half-life of 4.0 +/- 1.8 (SD) h in nontoxic goiter and 4.5 +/- 3.2 h in toxic goiter. This was followed by a more shallow slope with a half-life of 3.6 +/- 1.1 days in nontoxic goiter and 3.4 +/- 0.8 h in toxic goiter, the breaking point between the slopes lying approximately at 48-72 h. There was no significant difference between the half-life of Tg in patients with toxic or nontoxic goiters, respectively. There was a weak correlation between the weight of the removed thyroid tissue and the maximally obtained Tg concentration at the time of surgery, but no correlation with the levels before operation. Serum Tg was significantly lower three weeks after operation and approximately one year after surgery. In conclusion, different forms of the Tg molecules seem to be removed at different rates, independent on the type of goiter.

Adolescent↗