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Biomedical subjects

C M Montefusco

Publications and source records attributed to C M Montefusco.

28 records · Page 2Linked to original sources
PubMed1981

Intrafamilial lung xenografts from fox to dog.

The technical feasibility and rejection characteristics of intrafamilial fox-to-dog xenografts were studied. The results indicate that (1) both lungs of a smaller donor can be successfully transplanted into a single hemithorax of a larger recipient, (2) fox-to-dog lung xenografts are capable of providing total pulmonary function at tolerable right ventricular pressures, and (3) the rejection process of unmodified intrafamilial lung xenografts, was similar to and not more vigorous or more rapid than that of canine lung allografts in untreated recipients.

Animals↗
PubMed1979

Vascular ectasias of the right colon in the elderly: a distinct pathologic entity.

Vascular ectasias (angiodysplasias, arteriovenous malformations) of the cecum and ascending colon are a frequent cause of lower intestinal bleeding in the elderly that has been overlooked by clinicians and pathologists. Their nature and etiology have been poorly understood until recently. This article reviews the previous literature and presents a complete and detailed description of these lesions based on the examination of 87 areas showing vascular ectasia from 26 colons. Their morphology spans a spectrum from small focal early lesions to multiple large late lesions. The early lesions are characterized by markedly dilated, large, tortuous submucosal veins with minimal dilatation of their tributaries in the mucosa. The late lesions showed further dilatation of submucosal veins and venules and extensive replacement of the overlying mucosa by racemose collections of dilated and thin walled venules and capillaries, three of which demonstrated rupture into the colonic lumen. The pathology of these lesions is considered to be specific enough to establish vascular ectasias of the colon as a distinct entity.

Age Factors↗
PubMed1979

Long-term fate of lung autografts charged with providing total pulmonary function. I. Light and electron microscopic studies.

Two groups of dogs underwent light and electron microscopic examination of both lungs up to five years after left lung autotransplantation. In one group of four dogs that had undergone ligation of the right pulmonary artery at the time of left lung autotransplantation, no generalized or consistent lesions were present in the transplant except for slight distension of net capillaries and slight capillary basement membrane thickening. Aside from theseminor changes which were probably of no functional significance, most areas of lung examined up to five years after transplantation were normal. In the second group of four dogs that did not have contralateral pulmonary artery ligation at the time of left lung autotransplantation, no consistent abnormality was present in either the transplanted left or nontransplanted right lung. In three animals in this group, widespread normal areas were present bilaterally up to five years after transplantation. One animal in this group had focal changes consistent with chronic pulmonary disease in both of its lungs. Thus, transplanted lungs do not necessarily develop significant late pathologic lesions.

Animals↗
PubMed1979

Long-term fate of lung autografts charged with providing total pulmonary function. II. Hemodynamic, functional and angiographic studies.

Four dogs underwent autotransplantation of the left lung with immediate ligation of the right pulmonary artery and survived up to five years. Mean pulmonary artery pressures increased from 15 +/- 2 mmHg preoperatively to 23 +/- 4 mmHg immediately after operation and remained at the level (24 +/- 3 mmHg) up to five years operation. Arterial and venous blood gas values, determined while the animals were breathing ambient air spontaneously under light anesthesia, did not deteriorate with time and were within the normal range. The vascular resistance of the transplanted lungs up to five years after operation were not significantly different from those determined immediately after operation and remained lower than preoperative values, indicating that transplanted lungs retain indefinitely the ability to vasodilate with increased blood flow. Periodic angiography performed from 3-5 years after operation confirmed that the right lungs received no pulmonary blood flow and revealed normal vascular morphology except for moderate dilatation of the large arteries in the transplanted left lung. Thus, single transplanted lungs can provide total respiratory function while carrying the entire pulmonary blood flow at tolerable arterial pressures for at least five years without evidence of functional deterioration.

Angiography↗
PubMedDate not supplied

Autogenous vein graft thrombosis following exposure to calcium-free solutions (calcium paradox).

The morphological and functional effects of calcium-free and calcium-containing solutions on canine jugular vein intima were examined under conditions which closely resemble those techniques currently employed in peripheral vascular and aortocoronary bypass surgery. Veins that had been exposed only to calcium-containing solutions remained patent for the duration of the experimental period. Vein perfusion with a calcium-free solution, however, resulted in disruption of the jugular vein intima once calcium ions were reintroduced. Autogenous as a femoral arterial graft became thrombosed within 60 minutes. It is therefore suggested that vein grafts of autogenous origin be irrigated with calcium-containing solutions to prevent intimal damage and thrombosis.

Animals↗