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Biomedical subjects

C M Reeve

Publications and source records attributed to C M Reeve.

5 recordsLinked to original sources
PubMed1992

Orofacial manifestations of Melkersson-Rosenthal syndrome. A study of 42 patients and review of 220 cases from the literature.

We investigated orofacial manifestations in 42 patients with Melkersson-Rosenthal syndrome who were examined at our institution between 1965 and 1990. Patient histories and histologic and clinical findings were reviewed in detail. These data were compared with the oral findings in 220 cases that were reported in the literature between 1965 and 1990. There were 28 females in our study. The age at onset of signs and symptoms varied widely with a mean of 33.8 years. Most frequent initial signs were labial edema, facial swelling, and Bell's palsy. During the course of the disease, 75% of all patients had labial swelling, 50% had facial edema, and 33% had Bell's palsy. Swelling, erythema, or painful erosions that affected the gingiva, buccal mucosa, palate, or tongue were common intraoral symptoms. A comparison with patients reported in the literature revealed a similar frequency of extraoral symptoms but more prevalent intraoral symptoms in our patients.

Adolescent↗
PubMed1979

Lyophilized bone allografts in periodontal intraosseous defects.

Nine patients with 10 pairs of intraosseous periodontal defects were treated. Most of the patients had identical bilateral lesions (referred to as "mirror-image" defects). In each pair, one of the defects was randomly selected and treated as a flap and currettage control whereas the other defect was grafted with freeze-dried cortical powdered allografts of bone. Evaluation was based on radiographs, photographs, and measurements taken during both the initial surgery and at reentry approximately 1 year after transplantation. Control procedures (flap and curettage) demonstrated the same amount of osseous regeneration as that seen with the graft procedure. The amount of osseous regeneration demonstrated with the grafting procedures agreed with previously published studies. Evaluation revealed that (1) an autologous control such as incorporated in the "mirrow-image" design of this study is probably the most valid experimental model available for evaluating the clinical effectiveness of any human periodontal grafting procedures; (2) the effectiveness of freeze-dried cortical powdered bone allografts in human periodontal osseous defects is questionable and needs additional study; and (3) nongrafting procedures may be more effective in generating new attachments or reattachments in human periodontal osseous defects than previously believed.

Alveolar Process↗
PubMed1975

Uninherited dentinogenesis imperfecta.

The rare hereditary disease, dentinogenesis imperfecta, is a disturbance of dentin formation in both the deciduous and permanent dentitions. It may be associated with osteogenesis imperfecta, though it is probably that the two diseases are carried by different genes. This association was recognized in a 19-year-old man. Dentinogenesis imperfecta had been diagnosed at the age of 6 and had been regarded as a mutation; 11 years later, an atypical form of osteogenesis imperfecta developed. The case is atypical because of the apparent absence of dentinogenesis imperfecta in the patient's family. The dental manifestations may have heralded the bone disease.

Adult↗
PubMed1975

Lymphocytotosicity for gingival epithelial cells in periodontal disease.

An immune pathogenesis has been implicated in periodontal disease. Lymphocytotoxicity assays utilizing a suspension of peripheral blood lymphocytes incubated with allogeneic trypsinized gingival epithelium were performed. The results demonstrate a significant in vitro lymphocytotoxicity for gingival epithelial target cells when the aggressor lymphocytes are from patients with destructive periodontal disease (high PDI). No significant lymphocytotoxicity was demonstrated with lymphocytes for periodontal disease-free (low PDI) patients. We conclude that there is a significant reduction in gingival epithelial cell survival after an 18-hour incubation with aggressor lymphocytes obtained frompatients who have destructive periodontal disease, and suggest there is a pathologic relationship between the patient's lymphocytes and the disease process.

Cytotoxicity Tests, Immunologic↗