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Biomedical subjects

C M Scully

Publications and source records attributed to C M Scully.

28 records · Page 2Linked to original sources
PubMed1984

Oral lichen planus: an immunoperoxidase study using monoclonal antibodies to lymphocyte subsets.

Sixteen biopsies from patients with oral lichen planus (10), simple keratosis (3) and lichenoid reactions (3) were studied using monoclonal antibodies directed against lymphocyte markers. T lymphocytes predominated in the cellular infiltrates of the epithelium and lamina propria of all biopsies, and cells positive with Leu 3a and Leu 2a antibodies were also present at both sites in all specimens. However, many of the Leu 3a positive intraepithelial cells had a dendritic appearance and distribution consistent with their being Langerhans cells. Limited results from cell counts on three lichen planus specimens suggested that the majority of intraepithelial T cells were of the cytotoxic/suppressor phenotype (OKT3 and Leu 2a positive).

Antibodies, Monoclonal↗
PubMed1983

Bilateral parotid gland aplasia.

Bilateral parotid gland aplasia is a cause of xerostomia. A case is presented in which the clinical diagnosis was confirmed with the use of 99mTcO-4 salivary gland scintiscanning and computerised tomography. The literature of this rare condition is reviewed and significance to the patient discussed.

Humans↗
PubMed1980

Comparative opsonic activity for Steptococcus mutans in oral fluids, and phagocytic activity of blood, crevicular, and salivary polymorphonuclear leucocytes in rhesus monkeys.

The opsonic activity for Streptococcus mutans was assayed in serum, gingival crevicular fluid, parotid saliva and mixed saliva from rhesus monkeys immunized against dental caries with a vaccine of Streptococcus mutans in Freund's incomplete adjuvant. The phagocytic activities of polymorphonuclear leucocytes from the blood and gingival crevice were compared, and the effects of gingival crevicular fluid and mixed saliva on blood polymorphonuclear leucocyte viability and phagocytic activity were assessed. Heat-stable opsonic activity was detected in sera, crevicular fluid, and mixed saliva of immunized animals. Polymorphonuclear leucocytes from the gingival crevice and saliva retained viability, although this was lower than in cells from blood. Exposure of blood polymorphonuclear leucocytes to crevicular fluid or mixed saliva for 30 min resulted in no loss of cell viability or phagocytic activity, but saliva was cytotoxic on prolonged exposure. These results support the hypothesis that the opsonization and phagocytosis of cariogenic bacteria might be a mechanism involved in the immunological protection against dental caries.

Animals↗
PubMed1979

Bacterial and strain specificities in opsonization, phagocytosis and killing of Streptococcus mutans.

Opsonization of Streptococcus mutans, followed by phagocytosis and killing by polymorphonuclear leucocytes has been postulated as an effector mechanism in protection against dental caries. Opsonization was studied by using sera from monkeys immunized with killed Strep. mutans (sero-type c) and compared with sera from sham-immunized monkeys. Antibodies to Strep. mutans (sero-type c) induced maximal phagocytosis and killing of serotypes c and e, and this was significantly greater than with serotypes a and d; there was no significant phagocytosis or killing of serotype b. There was little or no opsonization with Actinomyces viscosus, Lactobacillus casei, Strep, sanguis and Strep. salivarius. The exception was Strep. CHT which showed significant phagocytosis and killing. The results suggest that immunization with the serotype c strain of Strep. mutans might offer protection against four of the five common serotypes of this organism.

Animals↗
PubMed1978

Passive immunisation with serum and immunoglobulins against dental caries in rhesus monkeys.

Active immunisation with Streptococcus mutans induced protection against dental caries in rhesus monkeys, and this was associated with serum antibodies. Passive transfer of immune serum with IgG, IgM, and IgA antibodies to Strep. mutans failed to induce protection against dental caries. However, when separated IgG, IgM, and IgA sera were given, IgG induced significant protection but IgA or IgM antibodies to Strep. mutans did not. IgA and IgM may compete or interfere with the protective effect of IgG antibodies, and the ratio of IgG/IgA and IgG/IgM antibodies might be an important factor in immunisation against dental caries.

Animals↗
PubMed1978

Passive immunization with antisera to Streptococcus mutans in the prevention of caries in rhesus monkeys.

1) The immunological mechanism of protection against dental caries has been investigated by passive immunization with antisera to S. mutans in the rhesus monkey. 2) Passive immunization with separated IgG, IgM and IgA from sera of immunized monkeys supports the concept that IgG, unlike IgA or IgM antibodies are protective. 3) The role of cell-mediated immunity has been explored by the use of transfer factor. This showed that protection against dental caries can be elicited by passive transfer of whole immune serum and cellular immunity, but not by cellular immunity or immune serum alone. 4) The results of active and passive immunization suggests that immuno-regulation of T and B cell interactions plays an important part in the effector mechanism of opsonization, phagocytosis and killing of S. mutans.

Animals↗