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Biomedical subjects

C M Verhamme

Publications and source records attributed to C M Verhamme.

8 recordsLinked to original sources

Luteotrophic activity of ectopically developing rat blastocysts.

The production of a luteotrophic hormone by ectopically transplanted rat blastocysts was demonstrated by transfer of blastocysts to the kidneys of cyclic and pseudopregnant mice and isogeneic rats. Pseudopregnancy was induced in nearly all cyclic mice bearing trophoblastic outgrowths but not in cyclic rats. In both mice and rats prolongation of pseudopregnancy was observed following ectopic transplantation of rat blastocysts at the time of normal egg implantation. It is concluded that ectopically developing rat trophoblastic tissue produces a luteotrophic hormone.

Animals

Lactate concentrations in pre-ovulatory follicles of pro-oestrous rats before and after onset of oocyte maturation.

Lactate concentrations were determined in pre-ovulatory follicles of rats at pro-oestrus before and after onset of oocyte maturation. It appeared that high concentrations prevail before and after the time of the expected LH surge (27 mM). The level in serum was about 5 mM. Explanted oocytes obtained from pre-puberal rats and surrounded by cumulus cells, matured in the presence of 20 mM lactate as sole exogenous energy source. It is argued that oxygen may be the limiting factor suppressing oocyte maturation in vivo.

Animals