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Biomedical subjects

C M Zarabi

Publications and source records attributed to C M Zarabi.

11 recordsLinked to original sources
PubMed1992

Diagnosis of systemic histoplasmosis in patients with AIDS.

To compare various laboratory methods for diagnosis of systemic histoplasmosis, we retrospectively reviewed the charts of 165 patients with AIDS (acquired immunodeficiency syndrome). In eight of those patients, systemic histoplasmosis was confirmed by laboratory techniques. The laboratory methods used were histomorphology and microbiology. Tissues and fluids used for fungal cultures and histochemical stains included blood, bone marrow, lung, skin, pleura, esophagus and colon biopsy specimens, sputum, cerebrospinal fluid, bronchial washing/brushing, and pleural and peritoneal fluids. Results were positive in 83% of blood cultures and 71% of bone marrow cultures, making these tissues the best sources of Histoplasma organisms for microbiologic study. Similarly, Histoplasma sp could be demonstrated by fungal stains in 75% of bone marrow biopsy specimens as the main source for morphologic documentation of systemic histoplasmosis. The other tissues and fluids were only occasionally positive either microbiologically or morphologically. There was cross-positivity between morphologic and microbiologic methods in 80% of confirmed cases, making both methods equally reliable. However, the results were obtained within 48 hours by histomorphology, allowing prompt initiation of antifungal therapy. Although more specific results were produced by microbiologic methods, it took 18 to 35 days to grow the organism.

AIDS-Related Opportunistic Infections↗
PubMed1992

Primary cerebral lymphoma manifested by dementia.

Primary cerebral lymphoma (PCL) accounts for less than 1% of intracranial neoplasms. In immunocompromised patients, multicentric lymphoma of the brain is typically manifested by focal neurologic deficits. In the immunocompetent individual, PCL involves leptomeninges and presents meningeal signs. Leptomeningeal lymphoma manifested by dementia has not been previously reported and should be included in the differential diagnosis of patients with Alzheimer's disease.

Aged↗
PubMed1991

Invasive polymycotic pneumonia in an uncontrolled diabetic.

We describe the clinical course of a patient with invasive polymycotic pneumonia due to Rhizopus arrhizus and Candida albicans. Both organisms were recovered from antemortem sputum cultures, and their clinical significance was confirmed by histologic examination of the lungs at autopsy. Circumstances leading to polymycotic infection are discussed, with special attention given to polymycotic infections involving Zygomycetes.

Candida albicans↗
PubMed1990

Allantois as the bursa-equivalent in man.

This article proposes the hypothesis that allantois is the anatomical homologue of bursa of Fabricius in mammalia. This hypothesis is based on immunohistochemical study of sections from hematopoietic organs of three fetuses with cloacal exstrophy. In the complex maldevelopment of cloacal exstrophy the common features are absence of distal midgut and exstrophy of cloaca with an exstropic intervening intestinal band. It has been suggested that gut is of dual origin and in addition to the yolk sac, allantois, absent in this maldevelopment, is involved in the embryogenesis of intestines by developing into distal midgut. There was absence of B-lymphocyte in two of three fetuses with rudimentary midgut and aplastic allantois. Meanwhile, B-cells were identified in the hematopoietic tissues and the prominent Peyer's patches of the more developed exstrophic allantois in the third case presented here. Therefore, it is concluded that allantois as the origin of distal midgut and lymphatic-rich ileocecal portion of digestive system is directly involved in the B-cell formation and represents the bursa of Fabricius in man.

Abnormalities, Multiple↗
PubMed1987

Disseminated rhabdomyosarcoma of the urinary bladder in an adult.

A rare case of alveolar rhabdomyosarcoma of the urinary bladder, manifested as a systemic disease in a 51-year-old woman, was diagnosed at necropsy. Diffuse lytic bone lesions and extensive bone marrow involvement with a leukoerythroblastic blood picture led to an initial clinical diagnosis of a hematologic malignancy.

Bone Marrow↗
PubMed1987

Occult metastasis of rhabdomyosarcoma to lymph node with sinus pattern.

Light microscopy of sections from the paraaortic and pelvic lymph nodes of a patient revealed micrometastases with sinus pattern. The diagnosis of metastatic rhabdomyosarcoma was confirmed ultrastructurally by demonstration of actin filaments and Z bands. To our knowledge occult metastases of rhabdomyosarcoma with purely sinus pattern have not been reported previously and diagnosis might be difficult to establish clinically or pathologically. However, recognition of the lymph node involvement changes the clinical staging and therapeutic regimen of this disease. Therefore, rhabdomyosarcoma should be included in the differential diagnosis of lymphadenopathies with sinus pattern. The disorders causing sinus pattern in lymph nodes are briefly reviewed.

Diagnosis, Differential↗
PubMed1986

A hypothesis on the allantoic origin of the distal midgut.

No satisfactory explanation for the absence of the ileocecal portion of the digestive system in the newborns with cloacal exstrophy has been offered previously. This is a report of such a case in which the lymphocytes and plasma cells were used as tissue markers to identify the origin of the lymphatic-rich ileocecal portion of the digestive tract. The absence of these cells, in this case demonstrated immunohistochemically, is suggestive of a dual origin of the midgut. Normal embryogenesis of the digestive system is reviewed and the possibility of participation of the allantois, in addition to the yolk sac, in the embryogenesis of the ileocecal segment of the gastrointestinal tract is discussed.

Allantois↗