[Macrocarcinoidosis of the stomach in a MEN 1 patient with Zollinger-Ellison syndrome and hyperparathyroidism].
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Adenoma↗
Biomedical subjects
C Müller-Schwefe
Publications and source records attributed to C Müller-Schwefe.
[Inflammatory aneurysms of the abdominal aorta].
The so-called "inflammatory" aneurysm of the aorta of the abdominal wall is a special form of the arteriosclerotic aneurysm of the aorta observed in 5-15% of the abdominal aorta aneurysms. It is characterized by more or less marked periaortal fibrotization. The pathological correlate is represented by lymphocytous and plasmacellular infiltrates that are mainly seen and identified in the region of the adventitia. The etiology has not yet been clarified. Since surgery of the inflammatory aneurysm of the abdominal wall aorta is rendered difficult due to neighbouring organs (e.g. ureters) becoming callous and adhesive, safe preoperative diagnosis is desirable. Suspicion of an aneurysm of the abdominal wall can be fairly safely confirmed by sonography. In case of a partially thrombotic aneurysm a characteristic fourfold stratification can be seen: free lumen/thrombus/calcified wall of aorta/law-echo outer layer. This last-named layer--the "inflammatory" portion--is tapelike, semicircular and more or less strongly developed. The inflammatory aneurysm of the abdominal wall is often symptomatic. Hence, the most important differential diagnosis concerns the covered perforation and the dissecting aortic aneurysm, as well as Ormond's disease, periaortal lymphomas and other retroperitoneal tumours.
Aorta, Abdominal↗
[Use of mezlocillin in open heart surgery (author's transl)].
Concentrations of mezlocillin in serum and heart tissue were studied in 29 patients undergoing open heart surgery. The antibiotic agent was administered three times as a bolus injection of 2 grams each: after induction of anaesthesia, after initiation of extracorporeal bypass (ECC) and shortly after discontinuation of ECC. Serum levels were measured in 25 patients from samples drawn 30 minutes after the bolus injection and subsequently biologic assays were carried out by the agar diffusion method. The mean initial values during the three phases of surgery were 119.2, 170.6 and 236.0 micrograms/ml, respectively; at 60 minutes the values were 61.3, 100.8 and 101.9 micrograms/ml. Calculation of the exponential curve enabled a mathematical comparison of the half-life of the substance during the pre-ECC, ECC and post-ECC periods. The most rapid elimination was found to occur prior to initiation of ECC, the slowest during ECC, while in the post-ECC period the elimination was similar to, but somewhat slower than that of, the pre-ECC period. The concentration, measured in the tissue of eleven aortic valves, averaged 35.96 (range 8.4 to 63.4) micrograms/ml. The mean concentration found in papillary muscles of the left ventricle, resected at the time of mitral valve replacement in six patients, was 31.54% (range 17.7 to 58.33) micrograms/ml. Mean tissue concentration found in five resected mitral valves was 43.77 (range 27.33 to 71.5) micrograms/ml. The findings indicate that mezlocillin, administered as described, will reach serum and tissue concentrations at all periods of open heart surgery well above those of the minimum inhibitory concentration of most clinically relevant bacteria.
Cardiac Surgical Procedures↗
[Unusual forms of the course of giant-cell arteritis].
Giant cell arthritis may be combined with retroperitoneal fibrosis, or lesions of the brachial plexus. Horner's Syndrome may develop. Occult vascular disease of cranial arteries was established in the presence of generalized arthritis, including the vessels of an ovarian tumor. Giant cell arthritis may be generalized at the time of detection, especially in patients presenting unusual clinical courses.
Aged↗