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Biomedical subjects

C Mahoney

Publications and source records attributed to C Mahoney.

9 recordsLinked to original sources
PubMed1995

Coping and marital equilibrium after stroke.

This study explored the effects of a cerebrovascular accident on seven older couples. The long interview method was used to identify major themes in seven couples' accounts of their post-stroke effects. Four major themes emerged which included experiencing physical changes, feeling down and worrying about the future, being restricted and adjusting to limits and seeking a new balance in the marriage. Stroke survivors and spouses differed in how they described the impact of the stroke for older couples. Support groups and family counseling may be used to facilitate couple adaptation after stroke. Longitudinal research is needed to explore adaptive coping post-stroke in both stroke survivors and stroke spouses.

Activities of Daily Living↗
PubMed1992

20-MST and PWC170 validity in non-Caucasian children in the UK.

The validity was investigated of 20-MST (20 Metre Endurance Shuttle Run Test) and PWC170 (Physical Working Capacity) field tests with laboratory-measured peak oxygen uptake (VO2peak) in a multiracial UK population of 12-year olds: 103 subjects completed the 20-MST and 96 of these completed the PWC170. To assess validity, a laboratory treadmill test was completed by ten boys and ten girls who had performed both field tests. VO2peak was 43.8 ml kg-1 min-1 for boys and 38.5 ml kg-1 min-1 for girls. Pearson product-moment correlation showed 20-MST to be a reliable measure of cardiorespiratory fitness (r = 0.83, boys; r = 0.76, girls, P less than 0.03), while correlations with PWC170 were lower (r = 0.64, boys; r = 0.54, girls) and not significant. The 20-MST was consistent in retest (n = 20) - reliability coefficients r = 0.73, boys; r = 0.88, girls; P less than 0.01. The results suggest 20-MST is a valid, measure of fitness in this population when compared with VO2peak. PWC170 is less valid, possibly due to cultural and social backgrounds. The cycle test was inappropriate in this population, especially for girls unaccustomed to exercise and cycling. The 20-MST test is recommended for large groups of children when facilities are limited. It requires limited skill or habituation and is relatively non-invasive.

Child↗
PubMed1988

Renal metabolism of calcitonin.

The kidneys account for approximately two-thirds of the metabolism of calcitonin, but relatively little is known regarding the details thereof. To further characterize this process, we examined the renal handling and metabolism of human calcitonin (hCT) by the isolated perfused rat kidney. We also studied the degradation of radiolabeled salmon calcitonin (sCT) by subcellular fractions prepared from isolated rabbit proximal tubules. The total renal (organ) clearance of immunoreactive hCT by the isolated kidney was 1.96 +/- 0.18 ml/min. This was independent of the perfusate total calcium concentration from 5.5 to 10.2 mg/dl. Total renal clearance exceeded the glomerular filtration rate (GFR, 0.68 +/- 0.05 ml/min), indicating filtration-independent removal. Urinary calcitonin clearance as a fraction of GFR averaged 2.6%. Gel filtration chromatography of medium from isolated kidneys perfused with 125I-labeled sCT showed the principal degradation products to be low molecular weight forms eluting with monoiodotyrosine. Intermediate size products were not detected. In the subcellular fractionation experiments, when carried out at pH 5.0, calcitonin hydrolysis exclusively followed the activities of the lysosomal enzyme N-acetyl-beta-glucosaminidase. Typically, at pH 7.5, 42% of total degradation occurred in the region of the brush-border enzyme alanyl aminopeptidase and 29% occurred in the region of the cytosolic enzyme phosphoglucomutase. Although 9% of the calcitonin-degrading activity was associated with basolateral membrane fractions, most of this activity could be accounted for by the presence of brush-border membranes.(ABSTRACT TRUNCATED AT 250 WORDS)

Acetylglucosaminidase↗
PubMed1982

Calculator assisted determination of dilutions for continuous infusion ICU medications.

A program has been developed for simplification of initial dilution calculations for several rapidly metabolized, vasoactive drugs that must be administered by continuous infusion. Included in the program is the capability for serial recalculation of drug dosage or iv flow rate is well as a checking routine to reduce errors. This program was developed primarily for the pediatric age group, where dilution of drugs into a small volume of diluent, accurate dosage calculations, and low iv flow rates are frequently necessary.

Computers↗